{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:53:49Z","timestamp":1790024029433,"version":"4.0.1"},"reference-count":57,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-17-CE15-00029"],"award-info":[{"award-number":["ANR-17-CE15-00029"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-16-IDEX-0006"],"award-info":[{"award-number":["ANR-16-IDEX-0006"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Mayaro virus (MAYV) is an emergent alphavirus that causes MAYV fever. It is often associated with debilitating symptoms, particularly arthralgia and myalgia. MAYV infection is becoming a considerable health issue that, unfortunately, lacks a specific antiviral treatment. Favipiravir, a broad-spectrum antiviral drug, has recently been shown to exert anti-MAYV activity in vitro. In the present study, the potential of Favipiravir to inhibit MAYV replication in an in vivo model was evaluated. Immunocompetent mice were orally administrated 300 mg\/kg\/dose of Favipiravir at pre-, concurrent-, or post-MAYV infection. The results showed a significant reduction in infectious viral particles and viral RNA transcripts in the tissues and blood of the pre- and concurrently treated infected mice. A significant reduction in the presence of both viral RNA transcript and infectious viral particles in the tissue and blood of pre- and concurrently treated infected mice was observed. By contrast, Favipiravir treatment post-MAYV infection did not result in a reduction in viral replication. Interestingly, Favipiravir strongly decreased the blood levels of the liver disease markers aspartate- and alanine aminotransferase in the pre- and concurrently treated MAYV-infected mice. Taken together, these results suggest that Favipiravir is a potent antiviral drug when administered in a timely manner.<\/jats:p>","DOI":"10.3390\/v13112213","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T21:57:49Z","timestamp":1635976669000},"page":"2213","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Favipiravir Inhibits Mayaro Virus Infection in Mice"],"prefix":"10.3390","volume":"13","author":[{"given":"Mich\u00e8le","family":"Bengue","sequence":"first","affiliation":[{"name":"MIVEGEC, Univ. Montpellier, IRD, CNRS, 34394 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-rada","family":"Pintong","sequence":"additional","affiliation":[{"name":"MIVEGEC, Univ. Montpellier, IRD, CNRS, 34394 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1048-0661","authenticated-orcid":false,"given":"Florian","family":"Liegeois","sequence":"additional","affiliation":[{"name":"MIVEGEC, Univ. 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Montpellier, IRD, CNRS, 34394 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"de Lamballerie","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Virus Emergents (UVE), Institut de Recherche pour le D\u00e9veloppement 190, IHU M\u00e9diterran\u00e9e Infection, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale 1207, Aix Marseille Universit\u00e9, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1825-1054","authenticated-orcid":false,"given":"Pierre","family":"Roques","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Virologie, Institut Pasteur de Guin\u00e9e, Conakry BP4416, Guinea"},{"name":"Immunologie des Maladies Virales Auto-Immunes, H\u00e9matologiques et Bact\u00e9riennes (IMVA-HB), Infectious Disease Models and Innovative Therapies (IDMIT): Commissariat a l\u2019Energie Atomique et aux Energies Alternatives (CEA), Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1184, Universit\u00e9 Paris Saclay, 92265 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4714-1006","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Choumet","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Environnement et Risques Infectieux Groupe Arbovirus, Institut Pasteur, Universit\u00e9 de Paris, 75724 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6485-3841","authenticated-orcid":false,"given":"Doroth\u00e9e","family":"Miss\u00e9","sequence":"additional","affiliation":[{"name":"MIVEGEC, Univ. 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