{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:30:57Z","timestamp":1760236257401,"version":"build-2065373602"},"reference-count":42,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T00:00:00Z","timestamp":1636761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9lius Foundation","doi-asserted-by":"publisher","award":["MS568"],"award-info":[{"award-number":["MS568"]}],"id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","award":["MS759"],"award-info":[{"award-number":["MS759"]}],"id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004155","name":"Magnus Ehrnrooth Foundation","doi-asserted-by":"publisher","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"10.13039\/501100004155","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Competitive State Research Funding of the Expert Responsibility Area of Tampere University Hospital","award":["9X033, 9V0040, 9v025"],"award-info":[{"award-number":["9X033, 9V0040, 9v025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome. We aimed to evaluate whether ABO and rhesus blood groups associate with the susceptibility or the severity of PUUV infection. We analyzed blood groups in 289 adult patients treated in Tampere University hospital due to PUUV infection during the years 1982\u20132017. Patients\u2019 blood group distribution was compared to that of healthy, voluntary blood donors living in the Tampere University Hospital responsibility area (n = 21,833). The severity of PUUV infection, as judged by the severity of acute kidney injury (AKI), thrombocytopenia, inflammation, capillary leakage, and the length of hospital care, was analyzed across the groups. The ABO and rhesus blood group distributions did not differ between the patients and blood donors. Patients with non-O blood groups had lower systolic blood pressure compared to patients with blood group O, but there was no difference in other markers of capillary leakage or in the severity of AKI. Minor deviations in the number of platelets and leukocytes were detected between the O and non-O blood groups. To conclude, patients with blood group O may be less susceptible to hypotension, but otherwise blood groups have no major influences on disease susceptibility or severity during acute PUUV infection.<\/jats:p>","DOI":"10.3390\/v13112271","type":"journal-article","created":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T20:52:28Z","timestamp":1636923148000},"page":"2271","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1882-0691","authenticated-orcid":false,"given":"Johanna","family":"Tiet\u00e4v\u00e4inen","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland"},{"name":"Department of Internal Medicine, Tampere University Hospital, 33520 Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Outi","family":"Laine","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland"},{"name":"Department of Internal Medicine, Tampere University Hospital, 33520 Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satu","family":"M\u00e4kel\u00e4","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland"},{"name":"Department of Internal Medicine, Tampere University Hospital, 33520 Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heini","family":"Huhtala","sequence":"additional","affiliation":[{"name":"Faculty of Social Sciences, Tampere University, 33250 Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4905-7564","authenticated-orcid":false,"given":"Ilkka","family":"P\u00f6rsti","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland"},{"name":"Department of Internal Medicine, Tampere University Hospital, 33520 Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti","family":"Vaheri","sequence":"additional","affiliation":[{"name":"Department of Virology, Medicum, University of Helsinki, 00290 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Mustonen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland"},{"name":"Department of Internal Medicine, Tampere University Hospital, 33520 Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nrmicro3066","article-title":"Uncovering the Mysteries of Hantavirus Infections","volume":"11","author":"Vaheri","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1017\/S0950268817002904","article-title":"Population-Based Seroprevalence of Puumala Hantavirus in Finland: Smoking as a Risk Factor","volume":"146","author":"Latronico","year":"2018","journal-title":"Epidemiol. Infect."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/23744235.2016.1274421","article-title":"Kidney Disease in Puumala Hantavirus Infection","volume":"49","author":"Mustonen","year":"2017","journal-title":"Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.antiviral.2013.10.001","article-title":"The Pathogenesis of Nephropathia Epidemica: New Knowledge and Unanswered Questions","volume":"100","author":"Mustonen","year":"2013","journal-title":"Antiviral Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/ki.1996.29","article-title":"Genetic Susceptibility to Severe Course of Nephropathia Epidemica Caused by Puumala Hantavirus","volume":"49","author":"Mustonen","year":"1996","journal-title":"Kidney Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.blre.2018.07.002","article-title":"Effect of the ABO Blood Group on Susceptibility to Severe Malaria: A Systematic Review and Meta-Analysis","volume":"33","author":"Degarege","year":"2019","journal-title":"Blood Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1186\/1475-2875-10-309","article-title":"Association of ABO Blood Group with Severe Falciparum Malaria in Adults: Case Control Study and Meta-Analysis","volume":"10","author":"Panda","year":"2011","journal-title":"Malaria J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1182\/blood-2007-03-077602","article-title":"The ABO Blood Group System and Plasmodium Falciparum Malaria","volume":"110","author":"Cserti","year":"2007","journal-title":"Blood"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"17471","DOI":"10.1073\/pnas.0705390104","article-title":"Blood Group O Protects Against Severe Plasmodium Falciparum Malaria through the Mechanism of Reduced Rosetting","volume":"104","author":"Rowe","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s13337-018-0426-8","article-title":"Blood Group AB is Associated with Severe Forms of Dengue Virus Infection","volume":"29","author":"Murugananthan","year":"2018","journal-title":"Virus Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.4103\/JLP.JLP_95_19","article-title":"Association of ABO Blood Groups with Dengue Fever and its Complications in a Tertiary Care Hospital","volume":"11","author":"Ravichandran","year":"2019","journal-title":"J. Lab Physicians"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1086\/512244","article-title":"Blood Group AB is Associated with Increased Risk for Severe Dengue Disease in Secondary Infections","volume":"195","author":"Kalayanarooj","year":"2007","journal-title":"J. Infect. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1001\/jama.293.12.1450-c","article-title":"ABO Blood Group and Susceptibility to Severe Acute Respiratory Syndrome","volume":"293","author":"Cheng","year":"2005","journal-title":"JAMA"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Golinelli, D., Boetto, E., Maietti, E., and Maria, P.F. (2020). The Association between ABO Blood Group and SARS-CoV-2 Infection: A Meta-Analysis. PLoS ONE, 15.","DOI":"10.1101\/2020.07.17.20155986"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e204","DOI":"10.1111\/bjh.16984","article-title":"ABO Phenotype and Death in Critically Ill Patients with COVID-19","volume":"190","author":"Leaf","year":"2020","journal-title":"Br. J. Haematol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"100785","DOI":"10.1016\/j.blre.2020.100785","article-title":"The Impact of ABO Blood Group on COVID-19 Infection Risk and Mortality: A Systematic Review and Meta-Analysis","volume":"48","author":"Liu","year":"2020","journal-title":"Blood Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"104485","DOI":"10.1016\/j.meegid.2020.104485","article-title":"Association between ABO Blood Groups and COVID-19 Infection, Severity and Demise: A Systematic Review and Meta-Analysis","volume":"84","author":"Wu","year":"2020","journal-title":"Infect. Genet Evol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e034114","DOI":"10.1136\/bmjopen-2019-034114","article-title":"ABO Blood Groups and Hepatitis B Virus Infection: A Systematic Review and Meta-Analysis","volume":"10","author":"Jing","year":"2020","journal-title":"BMJ Open"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"104245","DOI":"10.1016\/j.meegid.2020.104245","article-title":"ABO Blood Group-Associated Susceptibility to Norovirus Infection: A Systematic Review and Meta-Analysis","volume":"81","author":"Liao","year":"2020","journal-title":"Infect. Genet Evol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Davison, G.M., Hendrickse, H.L., and Matsha, T.E. (2020). Do Blood Group Antigens and the Red Cell Membrane Influence Human Immunodeficiency Virus Infection?. Cells, 9.","DOI":"10.3390\/cells9040845"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cca.2015.02.016","article-title":"Evolutionary Aspects of ABO Blood Group in Humans","volume":"444","author":"Franchini","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/rmv.581","article-title":"How to Diagnose Hantavirus Infections and Detect them in Rodents and Insectivores","volume":"18","author":"Vaheri","year":"2008","journal-title":"Rev. Med. Virol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1128\/CMR.00109-14","article-title":"Blood Groups in Infection and Host Susceptibility","volume":"28","author":"Cooling","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Ort\u00edn, R., Vila-Vicent, S., Carmona-Vicente, N., Santiso-Bell\u00f3n, C., Rodr\u00edguez-D\u00edaz, J., and Buesa, J. (2019). Histo-blood group antigens in children with symptomatic rotavirus infection. Viruses, 11.","DOI":"10.3390\/v11040339"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1086\/342413","article-title":"Human Leukocyte Antigen-B8-DR3 is a More Important Risk Factor for Severe Puumala Hantavirus Infection than the Tumor Necrosis Factor-A(-308) G\/A Polymorphism","volume":"186","author":"Mustonen","year":"2002","journal-title":"J. Infect Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e148","DOI":"10.1111\/bjh.16932","article-title":"Anti-A Isohaemagglutinin Titres and SARS-CoV-2 Neutralization: Implications for Children and Convalescent Plasma Selection","volume":"190","author":"Focosi","year":"2020","journal-title":"Br. J. Haematol."},{"key":"ref_27","first-page":"e93","article-title":"COVID-19 and ABO Blood Group: Another Viewpoint","volume":"190","author":"Maggipinto","year":"2020","journal-title":"Br. J. Haematol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/bjh.16797","article-title":"Association between ABO Blood Groups and Risk of SARS-CoV-2 Pneumonia","volume":"190","author":"Li","year":"2020","journal-title":"Br. J. Haematol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ijid.2020.12.025","article-title":"Covid-19 and Blood Groups: ABO Antibody Levels may also Matter","volume":"104","author":"Deleers","year":"2021","journal-title":"Int. J. Infect. Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"102838","DOI":"10.1016\/j.transci.2020.102838","article-title":"COVID-19 and the ABO Blood Group Connection","volume":"59","author":"Zaidi","year":"2020","journal-title":"Transfus. Apher. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"100763","DOI":"10.1016\/j.nmni.2020.100763","article-title":"Individuals with a Rh-Positive but Not Rh-Negative Blood Group are More Vulnerable to SARS-CoV-2 Infection: Demographics and Trend Study on COVID-19 Cases in Sudan","volume":"38","author":"Taha","year":"2020","journal-title":"New Microbes New Infect."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1161\/ATVBAHA.119.313658","article-title":"Genetically Determined ABO Blood Group and its Associations with Health and Disease","volume":"40","author":"Groot","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Li, S., and Schooling, C.M. (2020). A Phenome-Wide Association Study of ABO Blood Groups. BMC Med., 18.","DOI":"10.1186\/s12916-020-01795-4"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.1128\/JVI.02405-09","article-title":"Pathogenic Hantaviruses Direct the Adherence of Quiescent Platelets to Infected Endothelial Cells","volume":"84","author":"Gavrilovskaya","year":"2010","journal-title":"J. Virol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/MBC.0b013e328346a420","article-title":"Platelet Ligands and ADAMTS13 during Puumala Hantavirus Infection and Associated Thrombocytopenia","volume":"22","author":"Laine","year":"2011","journal-title":"Blood Coagul. Fibrinol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1161\/ATVBAHA.115.305337","article-title":"ABO Blood Group as a Model for Platelet Glycan Modification in Arterial Thrombosis","volume":"35","author":"Zhong","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/infdis\/jiv161","article-title":"Increased Thrombopoiesis and Platelet Activation in Hantavirus-Infected Patients","volume":"212","author":"Sundberg","year":"2015","journal-title":"J. Infect. Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.thromres.2015.10.003","article-title":"Hantavirus Infection-Induced Thrombocytopenia Triggers Increased Production but Associates with Impaired Aggregation of Platelets Except for Collagen","volume":"136","author":"Laine","year":"2015","journal-title":"Thromb. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.3389\/fimmu.2018.02098","article-title":"Neutrophil Activation in Acute Hemorrhagic Fever with Renal Syndrome is Mediated by Hantavirus-Infected Microvascular Endothelial Cells","volume":"9","author":"Strandin","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Outinen, T.K., Kuparinen, T., Jylh\u00e4v\u00e4, J., Lepp\u00e4nen, S., Mustonen, J., M\u00e4kel\u00e4, S., P\u00f6rsti, I., Syrj\u00e4nen, J., Vaheri, A., and Hurme, M. (2012). Plasma Cell-Free DNA Levels are Elevated in Acute Puumala Hantavirus Infection. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0031455"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1084\/jem.20131092","article-title":"\u03922 Integrin Mediates Hantavirus-Induced Release of Neutrophil Extracellular Traps","volume":"211","author":"Raftery","year":"2014","journal-title":"J. Exp. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.smim.2016.10.013","article-title":"Role of Platelets in Neutrophil Extracellular Trap (NET) Production and Tissue Injury","volume":"28","author":"Kim","year":"2016","journal-title":"Semin. Immunol."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/13\/11\/2271\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:29:40Z","timestamp":1760167780000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/13\/11\/2271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,13]]},"references-count":42,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["v13112271"],"URL":"https:\/\/doi.org\/10.3390\/v13112271","relation":{},"ISSN":["1999-4915"],"issn-type":[{"type":"electronic","value":"1999-4915"}],"subject":[],"published":{"date-parts":[[2021,11,13]]}}}