{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:41:04Z","timestamp":1760236864228,"version":"build-2065373602"},"reference-count":58,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Inherited chromosomally integrated (ici) human herpes virus 6 (HHV-6) is estimated to occur in 0.6\u20132.7% of people worldwide. HHV-6 comprises two distinct species: HHV-6A and HHV-6B. Both HHV-6A and HHV-6B integration have been reported. Several drugs are capable of activating iciHHV-6 in tissues, the consequences of which are poorly understood. We report herein a case of a woman with iciHHV-6A+ and iciHHV-6B+, who developed ulipristal acetate (a selective progesterone receptor modulator)-induced fulminant hepatic failure that required liver transplantation. We confirmed the presence of ~one copy per cell of both HHV-6A and HHV-6B DNA in her hair follicles using multiplex HHV-6A\/B real-time PCR and demonstrated the Mendelian inheritance of both iciHHV-6A and iciHHV-6B in her family members over three generations. Because of the rarity of this presentation, we discuss herein the possible links between reactivated HHV-6 from iciHHV-6A and\/or iciHHV-6B and adverse drug reactions, suggesting that iciHHV-6 could be screened before the introduction of any hepatotoxic drugs to exclude HHV-6 active disease or combined idiosyncratic drug-induced liver injury in these patients.<\/jats:p>","DOI":"10.3390\/v14010062","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T23:29:07Z","timestamp":1640906947000},"page":"62","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Investigation of Inherited Chromosomally Integrated Human Herpesvirus-6A+ and -6B+ in a Patient with Ulipristal Acetate-Induced Fulminant Hepatic Failure"],"prefix":"10.3390","volume":"14","author":[{"given":"Laure","family":"Izquierdo","sequence":"first","affiliation":[{"name":"Laboratoire de Virologie, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1193 AP-HP, H\u00f4pitaux Universitaires Paris Saclay, H\u00f4pital Paul-Brousse, 94800 Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9mence M.","family":"Canivet","sequence":"additional","affiliation":[{"name":"Laboratoire HIFIH, UPRES EA3859, SFR 4208, Service d\u2019H\u00e9pato-Gastroent\u00e9rologie et Oncologie Digestive, Centre Hospitalier Universitaire d\u2019Angers, Universit\u00e9 d\u2019Angers, 49000 Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"De Martin","sequence":"additional","affiliation":[{"name":"Centre H\u00e9pato-Biliaire, AP-HP, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1193, H\u00f4pitaux Universitaires Paris Saclay, H\u00f4pital Paul-Brousse, 94800 Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa M.","family":"Antonini","sequence":"additional","affiliation":[{"name":"Centre H\u00e9pato-Biliaire, AP-HP, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1193, H\u00f4pitaux Universitaires Paris Saclay, H\u00f4pital Paul-Brousse, 94800 Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6612-2030","authenticated-orcid":false,"given":"Anne-Marie","family":"Roque-Afonso","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1193 AP-HP, H\u00f4pitaux Universitaires Paris Saclay, H\u00f4pital Paul-Brousse, 94800 Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3149-8617","authenticated-orcid":false,"given":"Audrey","family":"Coilly","sequence":"additional","affiliation":[{"name":"Centre H\u00e9pato-Biliaire, AP-HP, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 1193, H\u00f4pitaux Universitaires Paris Saclay, H\u00f4pital Paul-Brousse, 94800 Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9465-2381","authenticated-orcid":false,"given":"Claire","family":"Deback","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie, AP-HP, H\u00f4pitaux Universitaires Paris Saclay, H\u00f4pital Paul-Brousse, 94800 Villejuif, France"},{"name":"Inserm U996, Inflammation, Microbiome and Immunosurveillance, Universit\u00e9 Paris-Saclay, 92140 Clamart, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1007\/s00705-012-1299-6","article-title":"Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2012)","volume":"157","author":"Adams","year":"2012","journal-title":"Arch. 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