{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T08:56:45Z","timestamp":1793869005706,"version":"4.6.1"},"reference-count":68,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000996","name":"Department of Foreign Affairs and Trade","doi-asserted-by":"publisher","award":["ST000DMX2"],"award-info":[{"award-number":["ST000DMX2"]}],"id":[{"id":"10.13039\/501100000996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001801","name":"University of Western Australia","doi-asserted-by":"publisher","award":["F51416"],"award-info":[{"award-number":["F51416"]}],"id":[{"id":"10.13039\/501100001801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The transmission of dengue and other medically important mosquito-borne viruses in the westernmost region of Indonesia is not well described. We assessed dengue and Zika virus seroprevalence in Aceh province, the westernmost area of the Indonesian archipelago. Serum samples collected from 199 randomly sampled healthy residents of Aceh Jaya in 2017 were analyzed for neutralizing antibodies by plaque reduction neutralization test (PRNT). Almost all study participants (198\/199; 99.5%) presented with multitypic profiles of neutralizing antibodies to two or more DENV serotypes, indicating transmission of multiple DENV in the region prior to 2017. All residents were exposed to one or more DENV serotypes by the age of 30 years. The highest geometric mean titers were measured for DENV-4, followed by DENV-1, DENV-2 and DENV-3. Among a subset of 116 sera, 27 neutralized ZIKV with a high stringency (20 with PRNT90 &gt; 10 and 7 with PRNT90 &gt; 40). This study showed that DENV is hyperendemic in the westernmost region of the Indonesian archipelago and suggested that ZIKV may have circulated prior to 2017.<\/jats:p>","DOI":"10.3390\/v14020219","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T20:42:26Z","timestamp":1643143346000},"page":"219","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hyperendemic Dengue and Possible Zika Circulation in the Westernmost Region of the Indonesian Archipelago"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7630-8413","authenticated-orcid":false,"given":"Harapan","family":"Harapan","sequence":"first","affiliation":[{"name":"Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia"},{"name":"Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia"},{"name":"Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia"},{"name":"School of Biomedical Sciences, University of Western Australia, Nedlands, WA 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kritu","family":"Panta","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, University of Western Australia, Nedlands, WA 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Michie","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, University of Western Australia, Nedlands, WA 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Ernst","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, University of Western Australia, Nedlands, WA 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzi","family":"McCarthy","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, University of Western Australia, Nedlands, WA 6009, Australia"},{"name":"Pathwest Laboratory Medicine, Nedlands, WA 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4357-5536","authenticated-orcid":false,"given":"Muhsin","family":"Muhsin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia"},{"name":"Department of Parasitology, School of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safarianti","family":"Safarianti","sequence":"additional","affiliation":[{"name":"Department of Parasitology, School of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tjut Mariam","family":"Zanaria","sequence":"additional","affiliation":[{"name":"Department of Parasitology, School of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5643-9384","authenticated-orcid":false,"given":"Mudatsir","family":"Mudatsir","sequence":"additional","affiliation":[{"name":"Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia"},{"name":"Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia"},{"name":"Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0986-2590","authenticated-orcid":false,"given":"R. Tedjo","family":"Sasmono","sequence":"additional","affiliation":[{"name":"Eijkman Institute for Molecular Biology, Jakarta 10430, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4715-6662","authenticated-orcid":false,"given":"Allison","family":"Imrie","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, University of Western Australia, Nedlands, WA 6009, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,24]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Changing epidemiology of dengue haemorrhagic fever in Indonesia","volume":"30","author":"Setiati","year":"2006","journal-title":"Dengue Bull."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Dhewantara, P.W., Jamil, K.F., Fajar, J.K., Saktianggi, P.P., Nusa, R., Garjito, T.A., Anwar, S., Firzan, F., Megawati, D., and Sasmono, R.T. (2021). 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