{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:05:32Z","timestamp":1791482732022,"version":"4.3.4"},"reference-count":35,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32002300"],"award-info":[{"award-number":["32002300"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Postdoctoral Science Foundation of China","award":["2021M690182"],"award-info":[{"award-number":["2021M690182"]}]},{"name":"Postdoctoral Science Foundation of Anhui Province","award":["2019B361"],"award-info":[{"award-number":["2019B361"]}]},{"name":"Postdoctoral Science Foundation of Anhui Province","award":["2020B419"],"award-info":[{"award-number":["2020B419"]}]},{"name":"Major Science and Technology Special Project in Anhui Province","award":["202003b06020006"],"award-info":[{"award-number":["202003b06020006"]}]},{"name":"Major Science and Technology Special Project in Anhui Province","award":["202003a06020012"],"award-info":[{"award-number":["202003a06020012"]}]},{"name":"China Agriculture Research System of MOF and MARA","award":["CARS-40"],"award-info":[{"award-number":["CARS-40"]}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2008085QC138"],"award-info":[{"award-number":["2008085QC138"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Postdoctoral Science Foundation of Hefei City","award":["2018PD22"],"award-info":[{"award-number":["2018PD22"]}]},{"name":"Anhui Province Poultry Industry Technology System","award":["AHCYJSTX-06"],"award-info":[{"award-number":["AHCYJSTX-06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Coriolus versicolor (C. versicolor) is a higher fungi or mushroom which is now known by its accepted scientific names as Trametes versicolor (L.) Lloyd. Many studies have shown that \u03b2-glucans from C. versicolor have various physiological activities, including activating macrophages to protect against Salmonella infection. However, whether \u03b2-glucans have antiviral effects has not been reported. Hence, the objective of this study was to confirm whether \u03b2-glucans could boost the immune response to combat influenza virus in mouse and chick models. The results show that \u03b2-glucans induced the expression of Dectin-1, costimulatory molecules (CD80\/86) and cytokines IL-6, IL-1\u03b2, IFN-\u03b2 and IL-10 in murine bone marrow dendritic cells (BMDCs). In addition, orally administered \u03b2-glucans reduced weight loss, mortality and viral titers in the lungs of mice infected with influenza virus and attenuated pathological lung damage caused by the virus in the mice. Orally administered \u03b2-glucans improved survival and reduced lung viral titers in chickens infected with H9N2 avian influenza virus. These results suggest that \u03b2-glucans have a significant antiviral effect. Therefore, \u03b2-glucans could become a potential immunomodulator against influenza virus.<\/jats:p>","DOI":"10.3390\/v14020237","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T20:42:26Z","timestamp":1643143346000},"page":"237","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["\u03b2-Glucans from Trametes versicolor (L.) Lloyd Is Effective for Prevention of Influenza Virus Infection"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8534-2039","authenticated-orcid":false,"given":"Shaohua","family":"Shi","sequence":"first","affiliation":[{"name":"Anhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Livestock and Poultry Epidemic Diseases Research Center of Anhui Province, Institute of Animal Husbandry and Veterinary Science, Anhui Academy of Agricultural Sciences, Hefei 230031, China"},{"name":"CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yin","sequence":"additional","affiliation":[{"name":"Anhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Livestock and Poultry Epidemic Diseases Research Center of Anhui Province, Institute of Animal Husbandry and Veterinary Science, Anhui Academy of Agricultural Sciences, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7558-8123","authenticated-orcid":false,"given":"Xuehuai","family":"Shen","sequence":"additional","affiliation":[{"name":"Anhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Livestock and Poultry Epidemic Diseases Research Center of Anhui Province, Institute of Animal Husbandry and Veterinary Science, Anhui Academy of Agricultural Sciences, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Dai","sequence":"additional","affiliation":[{"name":"Anhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Livestock and Poultry Epidemic Diseases Research Center of Anhui Province, Institute of Animal Husbandry and Veterinary Science, Anhui Academy of Agricultural Sciences, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9332-6514","authenticated-orcid":false,"given":"Jieru","family":"Wang","sequence":"additional","affiliation":[{"name":"Anhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Livestock and Poultry Epidemic Diseases Research Center of Anhui Province, Institute of Animal Husbandry and Veterinary Science, Anhui Academy of Agricultural Sciences, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Yin","sequence":"additional","affiliation":[{"name":"Anhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Livestock and Poultry Epidemic Diseases Research Center of Anhui Province, Institute of Animal Husbandry and Veterinary Science, Anhui Academy of Agricultural Sciences, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Livestock and Poultry Epidemic Diseases Research Center of Anhui Province, Institute of Animal Husbandry and Veterinary Science, Anhui Academy of Agricultural Sciences, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocheng","family":"Pan","sequence":"additional","affiliation":[{"name":"Anhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Livestock and Poultry Epidemic Diseases Research Center of Anhui Province, Institute of Animal Husbandry and Veterinary Science, Anhui Academy of Agricultural Sciences, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/zph.12685","article-title":"Human-infecting influenza A (H9N2) virus: A forgotten potential pandemic strain?","volume":"67","author":"Song","year":"2020","journal-title":"Zoonoses Public Health"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Trinh, T.T., Duong, B.T., Nguyen, A.T.V., Tuong, H.T., Hoang, V.T., Than, D.D., Nam, S.J., Sung, H.W., Yun, K.J., and Yeo, S.J. 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