{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T04:14:53Z","timestamp":1784434493066,"version":"3.55.0"},"reference-count":78,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["882631"],"award-info":[{"award-number":["882631"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI134768, AI140442"],"award-info":[{"award-number":["AI134768, AI140442"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2033260"],"award-info":[{"award-number":["2033260"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>A specialized and fine-tuned immune response of bats upon infection with viruses is believed to provide the basis for a \u201cfriendly\u201d coexistence with these pathogens, which are often lethal for humans and other mammals. First insights into the immunity of bats suggest that bats have evolved to possess their own strategies to cope with viral infections. Yet, the molecular details for this innocuous coexistence remain poorly described and bat infection models are the key to unveiling these secrets. In Jamaican fruit bats (Artibeus jamaicensis), a New World bat species, infection experiments with its (putative) natural viral pathogens Tacaribe virus (TCRV), rabies virus (RABV), and the bat influenza A virus (IAV) H18N11, have contributed to an accurate, though still incomplete, representation of the bat-imposed immunity. Surprisingly, though many aspects of their innate and adaptive immune responses differ from that of the human immune response, such as a contraction of the IFN locus and reduction in the number of immunoglobulin subclasses, variations could also be observed between Jamaican fruit bats and other bat species.<\/jats:p>","DOI":"10.3390\/v14020238","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T20:42:26Z","timestamp":1643143346000},"page":"238","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Different but Not Unique: Deciphering the Immunity of the Jamaican Fruit Bat by Studying Its Viriome"],"prefix":"10.3390","volume":"14","author":[{"given":"Quinnlan","family":"David","sequence":"first","affiliation":[{"name":"Institute of Virology, University Medical Center Freiburg, 79104 Freiburg, Germany"},{"name":"Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany"},{"name":"Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, Germany"},{"name":"Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Schountz","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2972-6855","authenticated-orcid":false,"given":"Martin","family":"Schwemmle","sequence":"additional","affiliation":[{"name":"Institute of Virology, University Medical Center Freiburg, 79104 Freiburg, Germany"},{"name":"Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5397-7497","authenticated-orcid":false,"given":"Kevin","family":"Ciminski","sequence":"additional","affiliation":[{"name":"Institute of Virology, University Medical Center Freiburg, 79104 Freiburg, Germany"},{"name":"Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,25]]},"reference":[{"key":"ref_1","unstructured":"Morrison, P. (2021, November 04). Artibeus jamaicensis. Animal Diversity Web. Available online: https:\/\/animaldiversity.org\/accounts\/Artibeus_jamaicensis\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1644\/1545-1410(2001)662<0001:AJ>2.0.CO;2","article-title":"Artibeus\u00a0jamaicensis","volume":"662","author":"Ortega","year":"2001","journal-title":"Mamm. Species"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"8666","DOI":"10.1073\/pnas.0912613107","article-title":"Adaptive evolution of energy metabolism genes and the origin of flight in bats","volume":"107","author":"Shen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_4","unstructured":"(2021, November 18). Jamaican Fruit-Eating Bat. Bat Conservation International: About Bats. Available online: https:\/\/www.batcon.org\/bat\/artibeus-jamaicensis\/."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1017\/S0950268808000460","article-title":"Dengue virus in Mexican bats","volume":"136","author":"Figueroa","year":"2008","journal-title":"Epidemiol. Infect."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"684","DOI":"10.7589\/2012-12-318","article-title":"Serologic evidence of flavivirus infection in bats in the Yucatan Peninsula of Mexico","volume":"49","author":"Ulloa","year":"2013","journal-title":"J. Wildl. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4269\/ajtmh.13-0524","article-title":"Dengue Virus in Bats from Southeastern Mexico","volume":"91","author":"Daszak","year":"2014","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/zph.12834","article-title":"West Nile and Zika viruses in bats from a suburban area of Merida, Yucatan, Mexico","volume":"68","author":"Puerto","year":"2021","journal-title":"Zoonoses Public Health"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/zph.12181","article-title":"Neotropical Bats from Costa Rica harbour Diverse Coronaviruses","volume":"62","author":"Jimenez","year":"2015","journal-title":"Zoonoses Public Health"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/zph.12460","article-title":"Serological evidence of widespread exposure of Grenada fruit bats to chikungunya virus","volume":"65","author":"Stone","year":"2018","journal-title":"Zoonoses Public Health"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Malmlov, A., Seetahal, J., Carrington, C., Ramkisson, V., Foster, J., Miazgowicz, K.L., Quackenbush, S., Rovnak, J., Negrete, O., and Munster, V. (2017). Serological evidence of arenavirus circulation among fruit bats in Trinidad. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0185308"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4269\/ajtmh.1978.27.162","article-title":"Serological Evidence of Infection of Tacaribe Virus and Arboviruses in Trinidadian Bats","volume":"27","author":"Price","year":"1978","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"327","DOI":"10.7589\/0090-3558-15.2.327","article-title":"Prevalence of selected zoonotic diseases in vertebrates from Haiti, 1972","volume":"15","author":"Trevino","year":"1979","journal-title":"J. Wildl. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.7589\/0090-3558-13.2.131","article-title":"Rabies Virus and Antibody in Bats in Grenada and Trinidad","volume":"13","author":"Price","year":"1977","journal-title":"J. Wildl. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Seetahal, J.F.R., Greenberg, L., Satheshkumar, P.S., Sanchez-Vazquez, M.J., LeGall, G., Singh, S., Ramkissoon, V., Schountz, T., Munster, V., and Oura, C.A.L. (2020). The Serological Prevalence of Rabies Virus-Neutralizing Antibodies in the Bat Population on the Caribbean Island of Trinidad. Viruses, 12.","DOI":"10.3390\/v12020178"},{"key":"ref_16","first-page":"1332935","article-title":"Natural exposure of bats in Grenada to rabies virus","volume":"7","author":"Zieger","year":"2017","journal-title":"Infect. Ecol. Epidemiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.1128\/JVI.00201-12","article-title":"Tacaribe Virus Causes Fatal Infection of An Ostensible Reservoir Host, the Jamaican Fruit Bat","volume":"86","author":"Bowen","year":"2012","journal-title":"J. Virol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"11447","DOI":"10.1073\/pnas.1000133107","article-title":"Natural hybridization generates mammalian lineage with species characteristics","volume":"107","author":"Larsen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"640","DOI":"10.4269\/ajtmh.1963.12.640","article-title":"Tacaribe Virus, a New Agent Isolated from Artibeus Bats and Mosquitoes in Trinidad, West Indies","volume":"12","author":"Downs","year":"1963","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Sayler, K.A., Barbet, A.F., Chamberlain, C., Clapp, W.L., Alleman, R., Loeb, J.C., and Lednicky, J.A. (2014). Isolation of Tacaribe Virus, a Caribbean Arenavirus, from Host-Seeking Amblyomma americanum Ticks in Florida. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0115769"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e00245-17","DOI":"10.1128\/mSphere.00245-17","article-title":"Transcriptomic Signatures of Tacaribe Virus-Infected Jamaican Fruit Bats","volume":"2","author":"Gerrard","year":"2017","journal-title":"mSphere"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Nahata, K.D., Bollen, N., Gill, M.S., Layan, M., Bourhy, H., Dellicour, S., and Baele, G. (2021). On the Use of Phylogeographic Inference to Infer the Dispersal History of Rabies Virus: A Review Study. Viruses, 13.","DOI":"10.3390\/v13081628"},{"key":"ref_23","unstructured":"WHO (2021, November 19). Rabies. World Health Organization Fact Sheets. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/rabies."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1007\/s00705-017-3484-0","article-title":"Immunological aspects of rabies: A literature review","volume":"162","author":"Katz","year":"2017","journal-title":"Arch. Virol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1080\/135502801753248097","article-title":"Experimental rabies virus infection in Artibeus jamaicensis bats with CVS-24 variants","volume":"7","author":"Reid","year":"2001","journal-title":"J. Neurovirol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cimid.2017.05.008","article-title":"Experimental infection of Artibeus intermedius with a vampire bat rabies virus","volume":"52","year":"2017","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/nn.3161","article-title":"Immune surveillance in the central nervous system","volume":"15","author":"Ousman","year":"2012","journal-title":"Nat. Neurosci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1080\/13550280590900427","article-title":"Rabies virus receptors","volume":"11","author":"Lafon","year":"2005","journal-title":"J. Neurovirol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.antiviral.2018.10.023","article-title":"Street rabies virus strains associated with insectivorous bats are less pathogenic than strains isolated from other reservoirs","volume":"160","author":"Fuoco","year":"2018","journal-title":"Antivir. Res."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Tong, S., Zhu, X., Li, Y., Shi, M., Zhang, J., Bourgeois, M., Yang, H., Chen, X., Recuenco-Cabrera, S., and Gomez, J. (2013). New World Bats Harbor Diverse Influenza A Viruses. PLoS Pathog., 9.","DOI":"10.1371\/journal.ppat.1003657"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1038\/s41564-019-0556-9","article-title":"Bat influenza viruses transmit among bats but are poorly adapted to non-bat species","volume":"4","author":"Ciminski","year":"2019","journal-title":"Nat. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3201\/eid2502.181246","article-title":"Bat Influenza A(HL18NL11) Virus in Fruit Bats, Brazil","volume":"25","author":"Campos","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41586-019-0955-3","article-title":"MHC class II proteins mediate cross-species entry of bat influenza viruses","volume":"567","author":"Karakus","year":"2019","journal-title":"Nature"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Malmlov, A., Bantle, C., Aboellail, T., Wagner, K., Campbell, C.L., Eckley, M., Chotiwan, N., Gullberg, R.C., Perera, R., and Tjalkens, R. (2019). Experimental Zika virus infection of Jamaican fruit bats (Artibeus jamaicensis) and possible entry of virus into brain via activated microglial cells. PLOS Neglected Trop. Dis., 13.","DOI":"10.1371\/journal.pntd.0007071"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.4269\/ajtmh.14-0361","article-title":"Experimental Inoculation of Artibeus jamaicensis Bats with Dengue Virus Serotypes 1 or 4 Showed No Evidence of Sustained Replication","volume":"91","author":"Moreno","year":"2014","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cimid.2016.12.004","article-title":"Neotropical primary bat cell lines show restricted dengue virus replication","volume":"50","year":"2017","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"21878","DOI":"10.1038\/srep21878","article-title":"Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis)","volume":"6","author":"Munster","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/S0140-6736(02)11772-7","article-title":"Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: A mechanism for the unusual severity of human disease?","volume":"360","author":"Cheung","year":"2002","journal-title":"Lancet"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Caballero, I.S., Honko, A.N., Gire, S.K., Winnicki, S.M., Mel\u00e9, M., Gerhardinger, C., Lin, A.E., Rinn, J.L., Sabeti, P.C., and Hensley, L.E. (2016). In vivo Ebola virus infection leads to a strong innate response in circulating immune cells. BMC Genom., 17.","DOI":"10.1186\/s12864-016-3060-0"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Colavita, F., Biava, M., Castilletti, C., Lanini, S., Miccio, R., Portella, G., Vairo, F., Ippolito, G., Capobianchi, M.R., and Di Caro, A. (2019). Inflammatory and Humoral Immune Response during Ebola Virus Infection in Survivor and Fatal Cases Occurred in Sierra Leone during the 2014\u20132016 Outbreak in West Africa. Viruses, 11.","DOI":"10.3390\/v11040373"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"154895","DOI":"10.1016\/j.cyto.2019.154895","article-title":"MERS-CoV infection is associated with downregulation of genes encoding Th1 and Th2 cytokines\/chemokines and elevated inflammatory innate immune response in the lower respiratory tract","volume":"126","author":"Alosaimi","year":"2020","journal-title":"Cytokine"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.chom.2020.05.009","article-title":"The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19?","volume":"27","author":"McKechnie","year":"2020","journal-title":"Cell Host Microbe"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/cid\/ciaa248","article-title":"Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China","volume":"71","author":"Qin","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Shaw, T., Srivastava, A., Chou, W.-C., Liu, L., Hawkinson, A., Glenn, T., Adams, R., and Schountz, T. (2012). Transcriptome Sequencing and Annotation for the Jamaican Fruit Bat (Artibeus jamaicensis). PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0048472"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/1471-2164-13-261","article-title":"The immune gene repertoire of an important viral reservoir, the Australian black flying fox","volume":"13","author":"Papenfuss","year":"2012","journal-title":"BMC Genom."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12864-015-2124-x","article-title":"De novo transcriptome reconstruction and annotation of the Egyptian rousette bat","volume":"16","author":"Lee","year":"2015","journal-title":"BMC Genom."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.ygeno.2005.01.009","article-title":"IRIS: A database surveying known human immune system genes","volume":"85","author":"Kelley","year":"2005","journal-title":"Genomics"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1073\/pnas.1518240113","article-title":"Contraction of the type I IFN locus and unusual constitutive expression of IFN-\u03b1 in bats","volume":"113","author":"Zhou","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.cell.2018.03.070","article-title":"The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity","volume":"173","author":"Pavlovich","year":"2018","journal-title":"Cell"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Kepler, T.B., Sample, C., Hudak, K., Roach, J., Haines, A., Walsh, A., and Ramsburg, E.A. (2010). Chiropteran types I and II interferon genes inferred from genome sequencing traces by a statistical gene-family assembler. BMC Genom., 11.","DOI":"10.1186\/1471-2164-11-444"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nri1604","article-title":"Mechanisms of type-I- and type-II-interferon-mediated signalling","volume":"5","author":"Platanias","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Zhou, P., Cowled, C., Marsh, G.A., Shi, Z., Wang, L.-F., and Baker, M.L. (2011). Type III IFN Receptor Expression and Functional Characterisation in the Pteropid Bat, Pteropus alecto. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0025385"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.4049\/jimmunol.1003115","article-title":"Type III IFNs in Pteropid Bats: Differential Expression Patterns Provide Evidence for Distinct Roles in Antiviral Immunity","volume":"186","author":"Zhou","year":"2011","journal-title":"J. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.immuni.2019.03.020","article-title":"IL-10 Family Cytokines IL-10 and IL-22: From Basic Science to Clinical Translation","volume":"50","author":"Ouyang","year":"2019","journal-title":"Immunity"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.3389\/fimmu.2017.01661","article-title":"Interferon (IFN)-\u03bb Takes the Helm: Immunomodulatory Roles of Type III IFNs","volume":"8","author":"Zanoni","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/icb.2012.9","article-title":"The interferons and their receptors--distribution and regulation","volume":"90","author":"Nguyen","year":"2012","journal-title":"Immunol. Cell Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41586-020-03128-0","article-title":"Lessons from the host defences of bats, a unique viral reservoir","volume":"589","author":"Irving","year":"2021","journal-title":"Nature"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.3389\/fimmu.2017.01098","article-title":"Immunological Control of Viral Infections in Bats and the Emergence of Viruses Highly Pathogenic to Humans","volume":"8","author":"Schountz","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.mie.2019.07.007","article-title":"Intercellular communication in the innate immune system through the cGAS-STING pathway","volume":"625","author":"Nandakumar","year":"2019","journal-title":"Methods Enzym."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.chom.2018.01.006","article-title":"Dampened STING-Dependent Interferon Activation in Bats","volume":"23","author":"Xie","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41564-019-0371-3","article-title":"Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host","volume":"4","author":"Ahn","year":"2019","journal-title":"Nat. Microbiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"28939","DOI":"10.1073\/pnas.2003352117","article-title":"Complementary regulation of caspase-1 and IL-1\u03b2 reveals additional mechanisms of dampened inflammation in bats","volume":"117","author":"Goh","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00251-010-0425-4","article-title":"Immunoglobulin heavy chain diversity in Pteropid bats: Evidence for a diverse and highly specific antigen binding repertoire","volume":"62","author":"Baker","year":"2010","journal-title":"Immunogenetics"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Wynne, J., Di Rubbo, A., Shiell, B.J., Beddome, G., Cowled, C., Peck, G.R., Huang, J., Grimley, S.L., Baker, M., and Michalski, W.P. (2013). Purification and Characterisation of Immunoglobulins from the Australian Black Flying Fox (Pteropus alecto) Using Anti-Fab Affinity Chromatography Reveals the Low Abundance of IgA. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0052930"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.dci.2010.08.011","article-title":"The two suborders of chiropterans have the canonical heavy-chain immunoglobulin (Ig) gene repertoire of eutherian mammals","volume":"35","author":"Butler","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1638\/2014-0141R.1","article-title":"Diagnosis and Palliative Management of Atopic Dermatitis in A Malayan Flying Fox (Pteropus Vampyrus)","volume":"46","author":"Goodnight","year":"2015","journal-title":"J. Zoo Wildl. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1126\/science.1230835","article-title":"Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity","volume":"339","author":"Zhang","year":"2013","journal-title":"Science"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.dci.2010.06.004","article-title":"The little brown bat, M. lucifugus, displays a highly diverse V H, D H and J H repertoire but little evidence of somatic hypermutation","volume":"35","author":"Bratsch","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0952-7915(02)00327-8","article-title":"Somatic immunoglobulin hypermutation","volume":"14","author":"Diaz","year":"2002","journal-title":"Curr. Opin. Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0966-3274(02)00062-X","article-title":"Natural killer cells and their receptors","volume":"10","author":"Middleton","year":"2002","journal-title":"Transpl. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.coi.2004.07.010","article-title":"Killer immunoglobulin-like receptors","volume":"16","author":"Moretta","year":"2004","journal-title":"Curr. Opin. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"37796","DOI":"10.1038\/srep37796","article-title":"Phenotypic and functional characterization of the major lymphocyte populations in the fruit-eating bat Pteropus alecto","volume":"6","author":"Periasamy","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3389\/fimmu.2019.00489","article-title":"Studies on B Cells in the Fruit-Eating Black Flying Fox (Pteropus alecto)","volume":"10","author":"Periasamy","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e02021-17","DOI":"10.1128\/JVI.02021-17","article-title":"Specific Mutations in the PB2 Protein of Influenza A Virus Compensate for the Lack of Efficient Interferon Antagonism of the NS1 Protein of Bat Influenza A-Like Viruses","volume":"92","author":"Aydillo","year":"2018","journal-title":"J. Virol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"10696","DOI":"10.1128\/JVI.01430-15","article-title":"Novel Bat Influenza Virus NS1 Proteins Bind Double-Stranded RNA and Antagonize Host Innate Immunity","volume":"89","author":"Turkington","year":"2015","journal-title":"J. Virol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e02097-17","DOI":"10.1128\/JVI.02097-17","article-title":"Unexpected Functional Divergence of Bat Influenza Virus NS1 Proteins","volume":"92","author":"Turkington","year":"2018","journal-title":"J. Virol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Zhou, B., Ma, J., Liu, Q., Bawa, B., Wang, W., Shabman, R., Duff, M., Lee, J., Lang, Y., and Cao, N. (2014). Characterization of Uncultivable Bat Influenza Virus Using a Replicative Synthetic Virus. PLOS Pathog., 10.","DOI":"10.1371\/journal.ppat.1004420"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1126\/science.1105113","article-title":"A Molecular Phylogeny for Bats Illuminates Biogeography and the Fossil Record","volume":"307","author":"Teeling","year":"2005","journal-title":"Science"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/2\/238\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:07:42Z","timestamp":1760134062000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/2\/238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,25]]},"references-count":78,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["v14020238"],"URL":"https:\/\/doi.org\/10.3390\/v14020238","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,25]]}}}