{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:48:44Z","timestamp":1760150924653,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007686","name":"Instituto Nacional de Perinatolog\u00eda","doi-asserted-by":"publisher","award":["2020-1-32"],"award-info":[{"award-number":["2020-1-32"]}],"id":[{"id":"10.13039\/501100007686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Cardiomyocyte injury and troponin T elevation has been reported within COVID-19 patients and are associated with a worse prognosis. Limited data report this association among COVID-19 pregnant patients. Objective: We aimed to analyze the association between troponin T levels in severe COVID-19 pregnant women and risk of viral sepsis, intensive care unit (ICU) admission, or maternal death. Methods: We performed a prospective cohort of all obstetrics emergency admissions from a Mexican National Institute. All pregnant women diagnosed by reverse transcription-polymerase chain reaction (RT-qPCR) for SARS-CoV-2 infection between October 2020 and May 2021 were included. Clinical data were collected, and routine blood samples were obtained at hospital admission. Seric troponin T was measured at admission. Results: From 87 included patients, 31 (35.63%) had severe COVID-19 pneumonia, and 6 (6.89%) maternal deaths. ROC showed a significant relationship between troponin T and maternal death (AUC 0.979, CI 0.500\u20131.000). At a cutoff point of 7 ng\/mL the detection rate for severe pneumonia was 83.3% (95%CI: 0.500\u20130.100) at 10% false-positive rate. Conclusion: COVID-19 pregnant women with elevated levels of troponin T present a higher risk of death and severe pneumonia.<\/jats:p>","DOI":"10.3390\/v14020271","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T01:43:27Z","timestamp":1643420607000},"page":"271","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Maternal Death by COVID-19 Associated with Elevated Troponin T Levels"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9524-4133","authenticated-orcid":false,"given":"Johnatan","family":"Torres-Torres","sequence":"first","affiliation":[{"name":"Clinical Research Branch, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes, Mexico City 11000, Mexico"},{"name":"ABC Medical Center, Medical Association, Mexico City 05330, Mexico"},{"name":"Iberoamerican Research Network in Obstetrics, Gynecology and Translational Medicine, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4711-3857","authenticated-orcid":false,"given":"Raigam Jafet","family":"Martinez-Portilla","sequence":"additional","affiliation":[{"name":"Clinical Research Branch, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes, Mexico City 11000, Mexico"},{"name":"ABC Medical Center, Medical Association, Mexico City 05330, Mexico"},{"name":"Iberoamerican Research Network in Obstetrics, Gynecology and Translational Medicine, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7276-8463","authenticated-orcid":false,"given":"Salvador","family":"Espino y Sosa","sequence":"additional","affiliation":[{"name":"Clinical Research Branch, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes, Mexico City 11000, Mexico"},{"name":"ABC Medical Center, Medical Association, Mexico City 05330, Mexico"},{"name":"Iberoamerican Research Network in Obstetrics, Gynecology and Translational Medicine, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4529-8296","authenticated-orcid":false,"given":"Juan Mario","family":"Solis-Paredes","sequence":"additional","affiliation":[{"name":"Clinical Research Branch, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes, Mexico City 11000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Antonio","family":"Hern\u00e1ndez-Pacheco","sequence":"additional","affiliation":[{"name":"Clinical Research Branch, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes, Mexico City 11000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5677-5572","authenticated-orcid":false,"given":"Paloma","family":"Mateu-Rogell","sequence":"additional","affiliation":[{"name":"Clinical Research Branch, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes, Mexico City 11000, Mexico"},{"name":"Iberoamerican Research Network in Obstetrics, Gynecology and Translational Medicine, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anette","family":"Cravioto-Sapien","sequence":"additional","affiliation":[{"name":"Clinical Research Branch, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes, Mexico City 11000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolfo","family":"Zamora-Madrazo","sequence":"additional","affiliation":[{"name":"Clinical Research Branch, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes, Mexico City 11000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9551-9021","authenticated-orcid":false,"given":"Guadalupe","family":"Estrada-Gutierrez","sequence":"additional","affiliation":[{"name":"Clinical Research Branch, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes, Mexico City 11000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Angel","family":"Nares-Torices","sequence":"additional","affiliation":[{"name":"Clinical Research Branch, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes, Mexico City 11000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma Patricia","family":"Becerra-Navarro","sequence":"additional","affiliation":[{"name":"ABC Medical Center, Medical Association, Mexico City 05330, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Medina-Jimenez","sequence":"additional","affiliation":[{"name":"Iberoamerican Research Network in Obstetrics, Gynecology and Translational Medicine, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Rafael","family":"Villafan-Bernal","sequence":"additional","affiliation":[{"name":"Iberoamerican Research Network in Obstetrics, Gynecology and Translational Medicine, Mexico City 06720, Mexico"},{"name":"Laboratory of Immunogenomics and Metabolic Diseases, INMEGEN, Mexico City 14610, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Rojas-Zepeda","sequence":"additional","affiliation":[{"name":"Instituto Materno Infantil del Estado de M\u00e9xico, Toluca 50170, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana Hipolita","family":"Loya-Diaz","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine Department, Hospital General de Mexico \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Casillas-Barrera","sequence":"additional","affiliation":[{"name":"Hospital de la Mujer, Mexico City 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,28]]},"reference":[{"key":"ref_1","unstructured":"Observatorio de Mortalidad Materna de M\u00e9xico (2021, November 19). 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