{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:13:22Z","timestamp":1787030002767,"version":"build-2736575974"},"reference-count":22,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Non-Profit Organization aimed to support community medicine research in Nagasaki","award":["2020"],"award-info":[{"award-number":["2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by the SFTS virus. It involves multiple organ systems, including the lungs. However, the significance of the lung involvement in SFTS remains unclear. In the present study, we aimed to investigate the relationship between the clinical findings and abnormalities noted in the chest computed tomography (CT) of patients with SFTS. The medical records of 22 confirmed SFTS patients hospitalized in five hospitals in Nagasaki, Japan, between April 2013 and September 2019, were reviewed retrospectively. Interstitial septal thickening and ground-glass opacity (GGO) were the most common findings in 15 (68.1%) and 12 (54.5%) patients, respectively, and lung GGOs were associated with fatalities. The SFTS patients with a GGO pattern were elderly, had a disturbance of the conscious and tachycardia, and had higher c-reactive protein levels at admission (p = 0.009, 0.006, 0.002, and 0.038, respectively). These results suggested that the GGO pattern in patients with SFTS displayed disseminated inflammation in multiple organs and that cardiac stress was linked to higher mortality. Chest CT evaluations may be useful for hospitalized patients with SFTS to predict their severity and as early triage for the need of intensive care.<\/jats:p>","DOI":"10.3390\/v14020279","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T01:43:27Z","timestamp":1643420607000},"page":"279","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Associations between Chest CT Abnormalities and Clinical Features in Patients with the Severe Fever with Thrombocytopenia Syndrome"],"prefix":"10.3390","volume":"14","author":[{"given":"Hiroki","family":"Ashizawa","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8102, Japan"},{"name":"Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki 852-8102, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1357-1676","authenticated-orcid":false,"given":"Kazuko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki 852-8102, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Ashizawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki 852-8102, Japan"},{"name":"Department of Infection Control and Education Center, Nagasaki University Hospital, Nagasaki 852-8102, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki 852-8102, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Iwanaga","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki 852-8102, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0696-5386","authenticated-orcid":false,"given":"Takahiro","family":"Takazono","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki 852-8102, Japan"},{"name":"Department of Infection Control and Education Center, Nagasaki University Hospital, Nagasaki 852-8102, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7577-476X","authenticated-orcid":false,"given":"Noriho","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki 852-8102, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Sumiyoshi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Isahaya General Hospital, Isahaya 854-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Ide","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Isahaya General Hospital, Isahaya 854-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuka","family":"Umemura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sasebo City General Hospital, Sasebo 857-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sasebo City General Hospital, Sasebo 857-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sasebo City General Hospital, Sasebo 857-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sasebo Chuo Hospital, Sasebo 857-1195, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7609-7679","authenticated-orcid":false,"given":"Masato","family":"Tashiro","sequence":"additional","affiliation":[{"name":"Department of Infection Control and Education Center, Nagasaki University Hospital, Nagasaki 852-8102, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Infection Control and Education Center, Nagasaki University Hospital, Nagasaki 852-8102, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7719-9631","authenticated-orcid":false,"given":"Shungo","family":"Katoh","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Nagasaki Rosai Hospital, Nagasaki 857-0134, Japan"},{"name":"Department of General Internal Medicine and Clinical Infectious Diseases, Fukushima Medical University, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konosuke","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koya","family":"Ariyoshi","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimpei","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Nagasaki University Hospital, Nagasaki 852-8102, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mya Myat Ngwe","family":"Tun","sequence":"additional","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouichi","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, 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Engl. J. Med."},{"key":"ref_2","unstructured":"World Health Organization (2020, May 14). An, R.&D Blueprint for Action to Prevent Epidemics: Plan of Action. Available online: https:\/\/www.who.int\/who-documents-detail\/an-r-d-blueprint-for-action-to-prevent-epidemics."},{"key":"ref_3","unstructured":"World Health Organization (2020, May 14). An, R.&D Blueprint for Action to Prevent Epidemics: Funding and Coordination Models for Prepared and Response. Available online: https:\/\/www.who.int\/blueprint\/what\/improving-coordination\/workstream_5_document_on_financing.pdf?ua=1."},{"key":"ref_4","first-page":"40","article-title":"Severe Fever with Thrombocytopenia Syndrome (SFTS), a New Tick-Borne Virus Infection\u2014The First Case Diagnosed in Japan, 2012","volume":"34","author":"Saijo","year":"2013","journal-title":"Infect. Agents Surveill. Rep."},{"key":"ref_5","unstructured":"National Institute for Infectious Diseases (NIID) (2014). Severe Fever with Thrombocytopenia Syndrome (SFTS) in Japan, 2013. IASR, 35, 31\u201332."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"692","DOI":"10.3201\/eid2604.191011","article-title":"Severe Fever with Thrombocytopenia Syndrome, Japan, 2013\u20132017","volume":"26","author":"Kobayashi","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"ref_7","first-page":"295","article-title":"Severe Fever with Thrombocytopenia Syndrome: Japan under Threat from Life-Threatening Emerging Tick-Borne Disease","volume":"3","author":"Crump","year":"2020","journal-title":"JMA J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jiac.2018.03.012","article-title":"Distribution of tick-borne diseases in Japan: Past patterns and implications for the future","volume":"24","author":"Yamaji","year":"2018","journal-title":"J. Infect. Chemother."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.jiac.2019.01.013","article-title":"Viral Load and Inflammatory Cytokine Dynamics Associated with the Prognosis of Severe Fever with Thrombocytopenia Syndrome Virus Infection: An Autopsy Case","volume":"25","author":"Nakamura","year":"2019","journal-title":"J. Infect. Chemother."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.3201\/eid2511.190061","article-title":"Severe Fever with Thrombocytopenia Syndrome Virus RNA in Semen, Japan","volume":"25","author":"Koga","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Akagi, K., Miyazaki, T., Oshima, K., Umemura, A., Shimada, S., Morita, K., Senju, H., Tashiro, M., Takazono, T., and Saijo, T. (2020). Detection of Viral RNA in Diverse Body Fluids in an SFTS Patient with Encephalopathy, Gastrointestinal Bleeding and Pneumonia: A Case Report and Literature Review. BMC Infect. Dis., 20.","DOI":"10.1186\/s12879-020-05012-8"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e17701","DOI":"10.1097\/MD.0000000000017701","article-title":"Comparison of Chest Radiographic Findings between Severe Fever with Thrombocytopenia Syndrome and Scrub Typhus: Single Center Observational Cross-Sectional Study in South Korea","volume":"98","author":"Yun","year":"2019","journal-title":"Medicine"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Deng, B., Zhou, B., Zhang, S., Zhu, Y., Han, L., Geng, Y., Jin, Z., Liu, H., Wang, D., and Zhao, Y. (2013). Clinical Features and Factors Associated with Severity and Fatality among Patients with Severe Fever with Thrombocytopenia Syndrome Bunyavirus Infection in Northeast China. PLoS ONE., 8.","DOI":"10.1371\/journal.pone.0080802"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Wu, H., Gao, J., Zhou, X., Zhu, R., Zhang, C., Bai, H., Abdullah, A.S., and Pan, H. (2017). Two Confirmed Cases of Severe Fever with Thrombocytopenia Syndrome with Pneumonia: Implication for a Family Cluster in East China. BMC Infect. Dis., 17.","DOI":"10.1186\/s12879-017-2645-9"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"R111","DOI":"10.1186\/cc12783","article-title":"A Multicenter, Prospective Validation Study of the Japanese Association for Acute Medicine Disseminated Intravascular Coagulation Scoring System in Patients with Severe Sepsis","volume":"17","author":"Gando","year":"2013","journal-title":"Crit. Care."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.virol.2015.03.010","article-title":"Therapeutic Effect of Post-Exposure Treatment with Antiserum on Severe Fever with Thrombocytopenia Syndrome (SFTS) in a Mouse Model of SFTS Virus Infection","volume":"482","author":"Shimada","year":"2015","journal-title":"Virology"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Truszkiewicz, K., Por\u0119ba, R., and Ga\u0107, P. (2021). Radiological Cardiothoracic Ratio in Evidence-Based Medicine. J. Clin. Med., 10.","DOI":"10.3390\/jcm10092016"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"S167","DOI":"10.1148\/rg.23si035504","article-title":"CT and MR Imaging of Pericardial Disease","volume":"23","author":"Wang","year":"2003","journal-title":"Radiographics."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.crad.2009.02.013","article-title":"A Simple Method to Approximate Liver Size on Cross-Sectional Images Using Living Liver Models","volume":"64","author":"Muggli","year":"2009","journal-title":"Clin. Radiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.acra.2017.06.006","article-title":"The Best Single Measurement for Assessing Splenomegaly in Patients with Cirrhotic Liver Morphology","volume":"24","author":"Nuffer","year":"2017","journal-title":"Acad. Radiol."},{"key":"ref_21","unstructured":"National Institute for Infectious Diseases (NIID) (2021, December 01). Severe Fever with Thrombocytopenia Syndrome (SFTS) in Japan. (In Japanese)."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1148\/rg.2018170048","article-title":"Radiographic and CT Features of Viral Pneumonia","volume":"38","author":"Koo","year":"2018","journal-title":"Radiographics"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/2\/279\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:10:23Z","timestamp":1760134223000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/2\/279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,28]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["v14020279"],"URL":"https:\/\/doi.org\/10.3390\/v14020279","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,28]]}}}