{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:47:27Z","timestamp":1790362047954,"version":"4.1.0"},"reference-count":35,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["20-04-60084"],"award-info":[{"award-number":["20-04-60084"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006769","name":"RSF","doi-asserted-by":"publisher","award":["19-74-10055"],"award-info":[{"award-number":["19-74-10055"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key R&amp;D Program of China","award":["2018YFC1708006"],"award-info":[{"award-number":["2018YFC1708006"]}]},{"name":"Innovation Platform Program","award":["2021-ZJ-T02"],"award-info":[{"award-number":["2021-ZJ-T02"]}]},{"name":"Central Asian Drug Discovery and Development Center of CAS","award":["CAM201903"],"award-info":[{"award-number":["CAM201903"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>To discover sources for novel anti-influenza drugs, we evaluated the antiviral potential of nine extracts from eight medicinal plants and one mushroom (Avena sativa L., Hordeum vulgare Linn. var. nudum Hook. f., Hippophae rhamnoides Linn., Lycium ruthenicum Murr., Nitraria tangutorum Bobr., Nitraria tangutorum Bobr. by-products, Potentilla anserina L., Cladina rangiferina (L.) Nyl., and Armillaria luteo-virens) from the Qinghai\u2013Tibetan plateau against the influenza A\/H3N2 virus. Concentrations lower than 125 \u03bcg\/mL of all extracts demonstrated no significant toxicity in MDCK cells. During screening, seven extracts (A. sativa, H. vulgare, H. rhamnoides, L. ruthenicum, N. tangutorum, C. rangiferina, and A. luteo-virens) exhibited antiviral activity, especially the water-soluble polysaccharide from the fruit body of the mushroom A. luteo-virens. These extracts significantly reduced the infectivity of the human influenza A\/H3N2 virus in vitro when used at concentrations of 15.6\u2013125 \u03bcg\/mL. Two extracts (N. tangutorum by-products and P. anserina) had no A\/H3N2 virus inhibitory activity. Notably, the extract obtained from the fruits of N. tangutorum and N. tangutorum by-products exhibited different anti-influenza effects. The results suggest that extracts of A. sativa, H. vulgare, H. rhamnoides, L. ruthenicum, N. tangutorum, C. rangiferina, and A. luteo-virens contain substances with antiviral activity, and may be promising sources of new antiviral drugs.<\/jats:p>","DOI":"10.3390\/v14020360","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T06:02:15Z","timestamp":1644472935000},"page":"360","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Anti-Influenza Activity of Medicinal Material Extracts from Qinghai\u2013Tibet Plateau"],"prefix":"10.3390","volume":"14","author":[{"given":"Olga","family":"Kurskaya","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Epidemiology and Biodiversity of Viruses, Federal Research Center of Fundamental and Translational Medicine, 630117 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5349-8362","authenticated-orcid":false,"given":"Elena","family":"Prokopyeva","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Epidemiology and Biodiversity of Viruses, Federal Research Center of Fundamental and Translational Medicine, 630117 Novosibirsk, Russia"},{"name":"Medical Department, Novosibirsk State University, Novosibirsk 630090, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Bi","sequence":"additional","affiliation":[{"name":"Qinghai Provincial Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Sobolev","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Epidemiology and Biodiversity of Viruses, Federal Research Center of Fundamental and Translational Medicine, 630117 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana","family":"Murashkina","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Epidemiology and Biodiversity of Viruses, Federal Research Center of Fundamental and Translational Medicine, 630117 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Shestopalov","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Epidemiology and Biodiversity of Viruses, Federal Research Center of Fundamental and Translational Medicine, 630117 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Wei","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Xining 810001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirill","family":"Sharshov","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Epidemiology and Biodiversity of Viruses, Federal Research Center of Fundamental and Translational Medicine, 630117 Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"key":"ref_1","first-page":"46","article-title":"Influenza: A virus of our times","volume":"79","author":"McCaughey","year":"2010","journal-title":"Ulst. 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