{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:50:50Z","timestamp":1790693450858,"version":"4.1.0"},"reference-count":106,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","award":["ANRS 2019-1"],"award-info":[{"award-number":["ANRS 2019-1"]}],"id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Viruses that transcribe their DNA within the nucleus have to adapt to the existing cellular mechanisms that govern transcriptional regulation. Recent technological breakthroughs have highlighted the highly hierarchical organization of the cellular genome and its role in the regulation of gene expression. This review provides an updated overview on the current knowledge on how the hepatitis B virus interacts with the cellular 3D genome and its consequences on viral and cellular gene expression. We also briefly discuss the strategies developed by other DNA viruses to co-opt and sometimes subvert cellular genome spatial organization.<\/jats:p>","DOI":"10.3390\/v14020445","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:48:41Z","timestamp":1645476521000},"page":"445","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Crosstalk between Hepatitis B Virus and the 3D Genome Structure"],"prefix":"10.3390","volume":"14","author":[{"given":"Jo\u00e3o Diogo","family":"Dias","sequence":"first","affiliation":[{"name":"Laboratoire de Virologie Mol\u00e9culaire, Institut de G\u00e9n\u00e9tique Humaine, CNRS, Universit\u00e9 de Montpellier, 34000 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazim","family":"Sarica","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie Mol\u00e9culaire, Institut de G\u00e9n\u00e9tique Humaine, CNRS, Universit\u00e9 de Montpellier, 34000 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Cournac","sequence":"additional","affiliation":[{"name":"Unit\u00e9 R\u00e9gulation Spatiale des G\u00e9nomes, CNRS, UMR 3525, Institut Pasteur, Universit\u00e9 de Paris, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Koszul","sequence":"additional","affiliation":[{"name":"Unit\u00e9 R\u00e9gulation Spatiale des G\u00e9nomes, CNRS, UMR 3525, Institut Pasteur, Universit\u00e9 de Paris, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6520-271X","authenticated-orcid":false,"given":"Christine","family":"Neuveut","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie Mol\u00e9culaire, Institut de G\u00e9n\u00e9tique Humaine, CNRS, Universit\u00e9 de Montpellier, 34000 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"a021444","DOI":"10.1101\/cshperspect.a021444","article-title":"Hepatocellular carcinoma","volume":"5","author":"Buendia","year":"2015","journal-title":"Cold Spring Harb. 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