{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:26:45Z","timestamp":1767914805464,"version":"3.49.0"},"reference-count":19,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007479","name":"Fondazione Cassa di Risparmio di Padova e Rovigo","doi-asserted-by":"publisher","award":["20\/02CoV"],"award-info":[{"award-number":["20\/02CoV"]}],"id":[{"id":"10.13039\/100007479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Vaccination with an mRNA COVID-19 vaccine determines not only a consistent reduction in the risk of SARS-CoV-2 infection but also contributes to disease attenuation in infected people. Of note, hyperinflammation and damage-associated molecular patterns (DAMPs) have been clearly associated with severe illness and poor prognosis in COVID-19 patients. In this report, we revealed a significant reduction in the levels of IL-1\u00df and DAMPs molecules, as S100A8 and High Mobility Group Protein B1 (HMGB1), in vaccinated patients as compared to non-vaccinated ones. COVID-19 vaccination indeed prevents severe clinical manifestations in patients and limits the release of systemic danger signals in SARS-CoV-2 infected people.<\/jats:p>","DOI":"10.3390\/v14030565","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T02:10:35Z","timestamp":1646878235000},"page":"565","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["COVID-19 Vaccination Limits Systemic Danger Signals in SARS-CoV-2 Infected Patients"],"prefix":"10.3390","volume":"14","author":[{"given":"Roberta","family":"Angioni","sequence":"first","affiliation":[{"name":"Fondazione Istituto di Ricerca Pediatrica\u2014Citt\u00e0 della Speranza, 35127 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lolita","family":"Sasset","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit, Padova University Hospital, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9820-5172","authenticated-orcid":false,"given":"Chiara","family":"Cioccarelli","sequence":"additional","affiliation":[{"name":"Fondazione Istituto di Ricerca Pediatrica\u2014Citt\u00e0 della Speranza, 35127 Padova, Italy"},{"name":"Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"S\u00e1nchez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Fondazione Istituto di Ricerca Pediatrica\u2014Citt\u00e0 della Speranza, 35127 Padova, Italy"},{"name":"Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Bertoldi","sequence":"additional","affiliation":[{"name":"Fondazione Istituto di Ricerca Pediatrica\u2014Citt\u00e0 della Speranza, 35127 Padova, Italy"},{"name":"Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina C.","family":"Putaggio","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit, Padova University Hospital, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Viola","sequence":"additional","affiliation":[{"name":"Fondazione Istituto di Ricerca Pediatrica\u2014Citt\u00e0 della Speranza, 35127 Padova, Italy"},{"name":"Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2869-2945","authenticated-orcid":false,"given":"Annamaria","family":"Cattelan","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit, Padova University Hospital, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7553-2170","authenticated-orcid":false,"given":"Barbara","family":"Molon","sequence":"additional","affiliation":[{"name":"Fondazione Istituto di Ricerca Pediatrica\u2014Citt\u00e0 della Speranza, 35127 Padova, Italy"},{"name":"Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"646333","DOI":"10.3389\/fimmu.2021.646333","article-title":"Cellular Immune Response to COVID-19 and Potential Immune Modulators","volume":"12","author":"Zhou","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_3","first-page":"225","article-title":"The signal pathways and treatment of cytokine storm in COVID-19","volume":"6","author":"Yang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41577-020-0331-4","article-title":"Pathological inflammation in patients with COVID-19: A key role for monocytes and macrophages","volume":"20","author":"Merad","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/joim.13144","article-title":"Cytokine storm syndrome in coronavirus disease 2019: A narrative review","volume":"289","author":"Gao","year":"2020","journal-title":"J. Intern. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/jmv.26232","article-title":"The cytokine storm and COVID-19","volume":"93","author":"Hu","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1001\/jamainternmed.2020.3313","article-title":"Is a \u201cCytokine Storm\u201d Relevant to COVID-19?","volume":"180","author":"Sinha","year":"2020","journal-title":"JAMA Intern. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41577-021-00536-9","article-title":"Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19","volume":"21","author":"Bonaventura","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.3389\/fimmu.2020.01708","article-title":"Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies","volume":"11","author":"Tang","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","article-title":"Safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine","volume":"383","author":"Polack","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s10787-021-00847-2","article-title":"COVID-19 vaccines and decreased transmission of SARS-CoV-2","volume":"29","author":"Vitiello","year":"2021","journal-title":"Inflammopharmacology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0140-6736(20)32623-4","article-title":"Oxford-AstraZeneca COVID-19 vaccine efficacy","volume":"397","author":"Knoll","year":"2021","journal-title":"Lancet"},{"key":"ref_13","unstructured":"NIH (2019). Coronavirus Disease 2019 (COVID-19) Treatment Guidelines, National Institutes of Health."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41435-021-00140-w","article-title":"Role of DAMPs in respiratory virus-induced acute respiratory distress syndrome-with a preliminary reference to SARS-CoV-2 pneumonia","volume":"22","author":"Land","year":"2021","journal-title":"Genes Immun."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/s41419-020-03151-z","article-title":"Age-severity matched cytokine profiling reveals specific signatures in Covid-19 patients","volume":"11","author":"Angioni","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"781352","DOI":"10.3389\/fimmu.2021.781352","article-title":"IL1\u03b2 Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 Axis","volume":"12","author":"Cioccarelli","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e05672","DOI":"10.1016\/j.heliyon.2020.e05672","article-title":"HMGB1 as a potential biomarker and therapeutic target for severe COVID-19","volume":"6","author":"Chen","year":"2020","journal-title":"Heliyon"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/s41423-020-0492-x","article-title":"Elevated serum levels of S100A8\/A9 and HMGB1 at hospital admission are correlated with inferior clinical outcomes in COVID-19 patients","volume":"17","author":"Chen","year":"2020","journal-title":"Cell Mol. Immunol."},{"key":"ref_19","first-page":"143299","article-title":"Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19","volume":"6","author":"Scozzi","year":"2021","journal-title":"JCI Insight"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/3\/565\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:33:51Z","timestamp":1760135631000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/3\/565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,9]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["v14030565"],"URL":"https:\/\/doi.org\/10.3390\/v14030565","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,9]]}}}