{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T18:55:58Z","timestamp":1773341758600,"version":"3.50.1"},"reference-count":83,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018692","name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","doi-asserted-by":"publisher","award":["fellowship grant"],"award-info":[{"award-number":["fellowship grant"]}],"id":[{"id":"10.13039\/501100018692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003762","name":"Institut Pasteur","doi-asserted-by":"publisher","award":["Internal funding"],"award-info":[{"award-number":["Internal funding"]}],"id":[{"id":"10.13039\/501100003762","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Laboratoire d\u2019excellence Integrative Biology of Emerging Infectious Diseases","award":["ANR-10-LABX-62-IBEID"],"award-info":[{"award-number":["ANR-10-LABX-62-IBEID"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Lassa virus (LASV), an Old World arenavirus, is responsible for hemorrhagic fevers in western Africa. The privileged tropism of LASV for endothelial cells combined with a dysregulated inflammatory response are the main cause of the increase in vascular permeability observed during the disease. Mopeia virus (MOPV) is another arenavirus closely related to LASV but nonpathogenic for non-human primates (NHPs) and has never been described in humans. MOPV is more immunogenic than LASV in NHPs and in vitro in human immune cell models, with more intense type I IFN and adaptive cellular responses. Here, we compared the transcriptomic and proteomic responses of human umbilical vein endothelial cells (HUVECs) to infection with the two viruses to further decipher the mechanisms involved in their differences in immunogenicity and pathogenicity. Both viruses replicated durably and efficiently in HUVECs, but the responses they induced were strikingly different. Modest activation was observed at an early stage of LASV infection and then rapidly shut down. By contrast, MOPV induced a late but more intense response, characterized by the expression of genes and proteins mainly associated with the type I IFN response and antigen processing\/presentation. Such a response is consistent with the higher immunogenicity of MOPV relative to LASV, whereas the lack of an innate response induced in HUVECs by LASV is consistent with its uncontrolled systemic dissemination through the vascular endothelium.<\/jats:p>","DOI":"10.3390\/v14030652","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T21:48:42Z","timestamp":1647899322000},"page":"652","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Infection of Human Endothelial Cells with Lassa Virus Induces Early but Transient Activation and Low Type I IFN Response Compared to the Closely-Related Nonpathogenic Mopeia Virus"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3639-362X","authenticated-orcid":false,"given":"Othmann","family":"Merabet","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Biologie des Infections Virales Emergentes, Institut Pasteur, 69007 Lyon, France"},{"name":"Centre International de Recherche en Infectiologie (CIRI), Universit\u00e9 de Lyon, INSERM U1111, Ecole Normale Sup\u00e9rieure de Lyon, Universit\u00e9 Lyon 1, CNRS, UMR5308, 69007 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Pietrosemoli","sequence":"additional","affiliation":[{"name":"Bioinformatics and Biostatistics Hub, Institut Pasteur, Universit\u00e9 de Paris, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8266-5908","authenticated-orcid":false,"given":"Emeline","family":"Perthame","sequence":"additional","affiliation":[{"name":"Bioinformatics and Biostatistics Hub, Institut Pasteur, Universit\u00e9 de Paris, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1589-445X","authenticated-orcid":false,"given":"Jean","family":"Armengaud","sequence":"additional","affiliation":[{"name":"Laboratoire Innovations Technologiques pour la D\u00e9tection et le Diagnostic (LI2D), Service de Pharmacologie et Immunoanalyse (SPI), Commissariat \u00e0 l\u2019Energie Atomique, 30200 Bagnols-sur-C\u00e8ze, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Charles","family":"Gaillard","sequence":"additional","affiliation":[{"name":"Laboratoire Innovations Technologiques pour la D\u00e9tection et le Diagnostic (LI2D), Service de Pharmacologie et Immunoanalyse (SPI), Commissariat \u00e0 l\u2019Energie Atomique, 30200 Bagnols-sur-C\u00e8ze, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginie","family":"Borges-Cardoso","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Biologie des Infections Virales Emergentes, Institut Pasteur, 69007 Lyon, France"},{"name":"Centre International de Recherche en Infectiologie (CIRI), Universit\u00e9 de Lyon, INSERM U1111, Ecole Normale Sup\u00e9rieure de Lyon, Universit\u00e9 Lyon 1, CNRS, UMR5308, 69007 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u00eflys","family":"Daniau","sequence":"additional","affiliation":[{"name":"ViroScan3D SAS, 01600 Tr\u00e9voux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Legras-Lachuer","sequence":"additional","affiliation":[{"name":"ViroScan3D SAS, 01600 Tr\u00e9voux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Carnec","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Biologie des Infections Virales Emergentes, Institut Pasteur, 69007 Lyon, France"},{"name":"Centre International de Recherche en Infectiologie (CIRI), Universit\u00e9 de Lyon, INSERM U1111, Ecole Normale Sup\u00e9rieure de Lyon, Universit\u00e9 Lyon 1, CNRS, UMR5308, 69007 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3234-7477","authenticated-orcid":false,"given":"Sylvain","family":"Baize","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Biologie des Infections Virales Emergentes, Institut Pasteur, 69007 Lyon, France"},{"name":"Centre International de Recherche en Infectiologie (CIRI), Universit\u00e9 de Lyon, INSERM U1111, Ecole Normale Sup\u00e9rieure de Lyon, Universit\u00e9 Lyon 1, CNRS, UMR5308, 69007 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"670","DOI":"10.4269\/ajtmh.1970.19.670","article-title":"Lassa Fever, a New Virus Disease of Man from West Africa","volume":"19","author":"Frame","year":"1970","journal-title":"Am. 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