{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:58:35Z","timestamp":1760151515518,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The new betacoronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the cause of COVID-19, and has spread rapidly around the world, reaching more than 200 countries, around 364 million people and causing more than 5 million deaths according to the World Health Organization, so this paper reports a fatal case of SARS-CoV-2 infection in a young pregnant woman with heart disease, without vertical transmission. A 26 years old patient at 28th week of pregnancy with regular prenatal care, presented dry cough, high fever, and severe respiratory distress. Due to her clinical symptoms, she sought medical care at a cardiology hospital in Northern Brazil. The medical conditions she presented were heart disease, rheumatic fever history and had no recent record of national or international travel. She was hospitalized and after clinical stabilization, she was referred for an emergency cesarean intervention. The young mother and the newborn were transferred to the intensive care unit after surgery, where diagnostic tests for respiratory viral infections, including SARS-CoV-2, were performed. The mother tested positive, while her newborn was negative for SARS-CoV-2 demonstrating no vertical transmission of SARS-CoV-2 in this severe case. This study reveals that despite the mother\u2019s initially mild symptoms, she progressed to severe clinical conditions resulting in death, although no vertical transmission was observed. This report highlights the relevance of comorbidities for the unfavorable clinical course of COVID-19.<\/jats:p>","DOI":"10.3390\/v14040675","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T21:31:25Z","timestamp":1648416685000},"page":"675","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Severe COVID-19 in Cardiopath Young Pregnant Patient without Vertical Transmission"],"prefix":"10.3390","volume":"14","author":[{"given":"Ana Paula Figueiredo de Montalv\u00e3o","family":"Fran\u00e7a","sequence":"first","affiliation":[{"name":"Biology of Infectious and Parasitic Agents Post-Graduate Program, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"},{"name":"Virology Laboratory, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielly do Vale","family":"Pereira","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia do Par\u00e1 Foundation, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine Val\u00e9ria","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia do Par\u00e1 Foundation, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1538-9130","authenticated-orcid":false,"given":"Fl\u00e1via Nunes","family":"Vieira","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia do Par\u00e1 Foundation, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine Santos","family":"Machado","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia do Par\u00e1 Foundation, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Aleixo","family":"Nogueira","sequence":"additional","affiliation":[{"name":"School of Medicine, University Center of State of Par\u00e1, Bel\u00e9m 66060-575, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0312-0553","authenticated-orcid":false,"given":"Ricardo Roberto de Souza","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Biology of Infectious and Parasitic Agents Post-Graduate Program, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"},{"name":"Virology Laboratory, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4571-4715","authenticated-orcid":false,"given":"Luiz Fernando Almeida","family":"Machado","sequence":"additional","affiliation":[{"name":"Biology of Infectious and Parasitic Agents Post-Graduate Program, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"},{"name":"Virology Laboratory, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2020, March 21). Pneumonia of Unknown Cause\u2014China. Available online: https:\/\/www.who.int\/csr\/don\/05-january-2020-pneumonia-of-unkown-cause-china\/en\/."},{"key":"ref_2","unstructured":"World Health Organization (WHO) (2020, March 22). Novel Coronavirus\u2014China. Available online: https:\/\/www.who.int\/csr\/don\/12-january-2020-novel-coronavirus-china\/en\/."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A novel Coronavirus from patients with pneumonia in China, 2019","volume":"382","author":"Zhu","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical Features of Patients Infected with 2019 Novel Coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/jama.2020.1585","article-title":"Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China","volume":"323","author":"Wang","year":"2020","journal-title":"JAMA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJMoa2001191","article-title":"First Case of 2019 Novel Coronavirus in the United States","volume":"382","author":"Holshue","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1056\/NEJMc2007605","article-title":"An Uncomplicated Delivery in a Patient with COVID-19 in the United States","volume":"382","author":"Iqbal","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_8","unstructured":"Brazilian Ministry of Health (BMH) (2021, December 21). Coronavirus Epidemiological Bulletin 2021, Available online: https:\/\/covid.saude.gov.br\/pt\/."},{"key":"ref_9","unstructured":"World Health Organization (WHO) (2020, April 01). Laboratory Testing of Human Suspected Cases of Novel Coronavirus (nCoV) Infection\u2014Interim Guidance. Available online: https:\/\/www.who.int\/health-topics\/coronavirus\/laboratory-diagnostics-for-novel-coronavirus."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2000045","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000045","article-title":"Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR","volume":"25","author":"Corman","year":"2020","journal-title":"Eurosurveillance"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.jiph.2020.04.004","article-title":"Unlikely SARS-CoV-2 vertical transmission from mother to child: A Case Report","volume":"13","author":"Peng","year":"2020","journal-title":"J. Infect. Public Health"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"111.e1","DOI":"10.1016\/j.ajog.2020.04.014","article-title":"Coronavirus Disease 2019 (COVID-19) in Pregnant Women: A Report Based on 116 Cases","volume":"223","author":"Yan","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_13","first-page":"1","article-title":"Coronavirus disease 2019 (COVID-19) and pregnancy: A systematic review","volume":"30","author":"Yang","year":"2020","journal-title":"J. Matern.-Fetal Neonatal Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ajog.2020.03.021","article-title":"Coronavirus disease 2019 (COVID-19) pandemic and pregnancy","volume":"222","author":"Dashraath","year":"2020","journal-title":"Am J Obstet Gynecol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ijid.2020.04.065","article-title":"Coronavirus disease 2019 in pregnancy","volume":"95","author":"Qiancheng","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"100053","DOI":"10.1016\/j.jcvp.2021.100053","article-title":"Retrospective epidemiology of the SARS-CoV-2 (and COVID-19) epidemic among 27 Brazilian cities","volume":"1","author":"Lima","year":"2021","journal-title":"J. Clin. Virol. Plus"},{"key":"ref_17","first-page":"861","article-title":"Severe COVID-19 during Pregnancy and Possible Vertical Transmission","volume":"18","author":"Alzamora","year":"2020","journal-title":"Am. J. Perinatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"799","DOI":"10.5858\/arpa.2020-0901-SA","article-title":"An Analysis of 38 Pregnant Women With COVID-19, Their Newborn Infants, and Maternal-Fetal Transmission of SARS-CoV-2: Maternal Coronavirus Infections and Pregnancy Outcomes","volume":"144","author":"Schwartz","year":"2020","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1002\/jmv.25959","article-title":"COVID-19 in pregnancy: Risk of adverse neonatal outcomes","volume":"92","author":"Mehan","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1111\/1471-0528.16470","article-title":"Clinical characteristics and risk factors for mortality in obstetric patients with severe COVID-19 in Brazil: A surveillance database analysis","volume":"127","author":"Takemoto","year":"2020","journal-title":"BJOG"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5128","DOI":"10.1038\/s41467-020-18933-4","article-title":"Analysis of SARS-CoV-2 vertical transmission during pregnancy","volume":"11","author":"Fenizia","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ajog.2020.07.049","article-title":"Vertical transmission of coronavirus disease 2019: A systematic review and meta-analysis","volume":"224","author":"Kotlyar","year":"2021","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/archdischild-2020-319791","article-title":"Incidence of SARS-CoV-2 vertical transmission: A meta-analysis","volume":"106","author":"Goh","year":"2021","journal-title":"Arch. Dis. Child.-Fetal Neonatal Ed."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/4\/675\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:42:55Z","timestamp":1760136175000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/4\/675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,25]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["v14040675"],"URL":"https:\/\/doi.org\/10.3390\/v14040675","relation":{},"ISSN":["1999-4915"],"issn-type":[{"type":"electronic","value":"1999-4915"}],"subject":[],"published":{"date-parts":[[2022,3,25]]}}}