{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:52:00Z","timestamp":1776703920243,"version":"3.51.2"},"reference-count":66,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T00:00:00Z","timestamp":1650067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["075-15-2020-902"],"award-info":[{"award-number":["075-15-2020-902"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The rapid emergence of antibiotic resistance is of major concern globally. Among the most worrying pathogenic bacteria are vancomycin-resistant enterococci. Phage therapy is a highly promising method for controlling enterococcal infections. In this study, we described two virulent tailed bacteriophages possessing lytic activity against Enterococcus faecalis and E. faecium isolates. The SSsP-1 bacteriophage belonged to the Saphexavirus genus of the Siphoviridae family, and the GVEsP-1 bacteriophage belonged to the Schiekvirus genus of Herelleviridae. The genomes of both viruses carried putative components of anti-CRISPR systems and did not contain known genes coding for antibiotic-resistance determinants and virulence factors. The conservative arrangement of protein-coding sequences in Saphexavirus and Schiekvirus genomes taken together with positive results of treating enterococcal peritonitis in an animal infection model imply the potential suitability of GVEsP-1 and SSsP-1 bacteriophages for clinical applications.<\/jats:p>","DOI":"10.3390\/v14040831","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T02:04:22Z","timestamp":1650420262000},"page":"831","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Two Novel Lytic Bacteriophages Infecting Enterococcus spp. Are Promising Candidates for Targeted Antibacterial Therapy"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8028-8643","authenticated-orcid":false,"given":"Pavel V.","family":"Tkachev","sequence":"first","affiliation":[{"name":"Scientific and Educational Center \u201cMolecular Bases of Interaction of Microorganisms and Human\u201d of the WCRC \u201cCenter for Personalized Medicine\u201d, Institute of Experimental Medicine, 197022 Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3062-3316","authenticated-orcid":false,"given":"Ivan M.","family":"Pchelin","sequence":"additional","affiliation":[{"name":"Scientific and Educational Center \u201cMolecular Bases of Interaction of Microorganisms and Human\u201d of the WCRC \u201cCenter for Personalized Medicine\u201d, Institute of Experimental Medicine, 197022 Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniil V.","family":"Azarov","sequence":"additional","affiliation":[{"name":"Scientific and Educational Center \u201cMolecular Bases of Interaction of Microorganisms and Human\u201d of the WCRC \u201cCenter for Personalized Medicine\u201d, Institute of Experimental Medicine, 197022 Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2303-1144","authenticated-orcid":false,"given":"Andrey N.","family":"Gorshkov","sequence":"additional","affiliation":[{"name":"Smorodintsev Research Institute of Influenza, Ministry of Health of the Russian Federation, 197376 Saint Petersburg, Russia"},{"name":"Laboratory of Pathomorphology, Almazov National Research Centre, 197341 Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga V.","family":"Shamova","sequence":"additional","affiliation":[{"name":"Scientific and Educational Center \u201cMolecular Bases of Interaction of Microorganisms and Human\u201d of the WCRC \u201cCenter for Personalized Medicine\u201d, Institute of Experimental Medicine, 197022 Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander V.","family":"Dmitriev","sequence":"additional","affiliation":[{"name":"Scientific and Educational Center \u201cMolecular Bases of Interaction of Microorganisms and Human\u201d of the WCRC \u201cCenter for Personalized Medicine\u201d, Institute of Experimental Medicine, 197022 Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5206-6656","authenticated-orcid":false,"given":"Artemiy E.","family":"Goncharov","sequence":"additional","affiliation":[{"name":"Scientific and Educational Center \u201cMolecular Bases of Interaction of Microorganisms and Human\u201d of the WCRC \u201cCenter for Personalized Medicine\u201d, Institute of Experimental Medicine, 197022 Saint Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00394-017-1445-8","article-title":"Gut microbiota functions: Metabolism of nutrients and other food components","volume":"57","author":"Rowland","year":"2018","journal-title":"Eur. 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