{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:41:30Z","timestamp":1760139690246,"version":"build-2065373602"},"reference-count":148,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T00:00:00Z","timestamp":1650672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["308783\/2019-0, 314288\/2018\u20130"],"award-info":[{"award-number":["308783\/2019-0, 314288\/2018\u20130"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004612","name":"Funda\u00e7\u00e3o Arauc\u00e1ria","doi-asserted-by":"publisher","award":["Conv\u00eanio 116\/2018 - Protocolo 50530"],"award-info":[{"award-number":["Conv\u00eanio 116\/2018 - Protocolo 50530"]}],"id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfeicoamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["CRSII5_202301\/1"],"award-info":[{"award-number":["CRSII5_202301\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 22167-390884018"],"award-info":[{"award-number":["EXC 22167-390884018"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The long search for the environmental trigger of the endemic pemphigus foliaceus (EPF, fogo selvagem) has not yet resulted in any tangible findings. Here, we searched for genetic associations and the differential expression of host genes involved in early viral infections and innate antiviral defense. Genetic variants could alter the structure, expression sites, or levels of the gene products, impacting their functions. By analyzing 3063 variants of 166 candidate genes in 227 EPF patients and 194 controls, we found 12 variants within 11 genes associated with differential susceptibility (p &lt; 0.005) to EPF. The products of genes TRIM5, TPCN2, EIF4E, EIF4E3, NUP37, NUP50, NUP88, TPR, USP15, IRF8, and JAK1 are involved in different mechanisms of viral control, for example, the regulation of viral entry into the host cell or recognition of viral nucleic acids and proteins. Only two of nine variants were also associated in an independent German cohort of sporadic PF (75 patients, 150 controls), aligning with our hypothesis that antiviral host genes play a major role in EPF due to a specific virus\u2013human interaction in the endemic region. Moreover, CCL5, P4HB, and APOBEC3G mRNA levels were increased (p &lt; 0.001) in CD4+ T lymphocytes of EPF patients. Because there is limited or no evidence that these genes are involved in autoimmunity, their crucial role in antiviral responses and the associations that we observed support the hypothesis of a viral trigger for EPF, presumably a still unnoticed flavivirus. This work opens new frontiers in searching for the trigger of EPF, with the potential to advance translational research that aims for disease prevention and treatment.<\/jats:p>","DOI":"10.3390\/v14050879","type":"journal-article","created":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T02:22:02Z","timestamp":1650766922000},"page":"879","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Genetic Associations and Differential mRNA Expression Levels of Host Genes Suggest a Viral Trigger for Endemic Pemphigus Foliaceus"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4000-2417","authenticated-orcid":false,"given":"Val\u00e9ria Bumiller-Bini","family":"Hoch","sequence":"first","affiliation":[{"name":"Laboratory of Human Molecular Genetics, Department of Genetics, Federal University of Paran\u00e1 (UFPR), Curitiba 81531-980, Brazil"},{"name":"Postgraduate Program in Genetics, Department of Genetics, Federal University of Paran\u00e1 (UFPR), Curitiba 81531-980, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Fl\u00e1via","family":"Kohler","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Genetics, Department of Genetics, Federal University of Paran\u00e1 (UFPR), Curitiba 81531-980, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5665-8547","authenticated-orcid":false,"given":"Danillo G.","family":"Augusto","sequence":"additional","affiliation":[{"name":"Laboratory of Human Molecular Genetics, Department of Genetics, Federal University of Paran\u00e1 (UFPR), Curitiba 81531-980, Brazil"},{"name":"Postgraduate Program in Genetics, Department of Genetics, Federal University of Paran\u00e1 (UFPR), Curitiba 81531-980, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara Cristina","family":"Lobo-Alves","sequence":"additional","affiliation":[{"name":"Laboratory of Human Molecular Genetics, Department of Genetics, Federal University of Paran\u00e1 (UFPR), Curitiba 81531-980, Brazil"},{"name":"Research Institut Pel\u00e9 Pequeno Pr\u00edncipe, Curitiba 80250-060, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Malheiros","sequence":"additional","affiliation":[{"name":"Laboratory of Human Molecular Genetics, Department of Genetics, Federal University of Paran\u00e1 (UFPR), Curitiba 81531-980, Brazil"},{"name":"Postgraduate Program in Genetics, Department of Genetics, Federal University of Paran\u00e1 (UFPR), Curitiba 81531-980, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2298-8617","authenticated-orcid":false,"given":"Gabriel Adelman","family":"Cipolla","sequence":"additional","affiliation":[{"name":"Laboratory of Human Molecular Genetics, Department of Genetics, Federal University of Paran\u00e1 (UFPR), Curitiba 81531-980, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelica Beate Winter","family":"Boldt","sequence":"additional","affiliation":[{"name":"Laboratory of Human Molecular Genetics, Department of Genetics, Federal University of Paran\u00e1 (UFPR), Curitiba 81531-980, Brazil"},{"name":"Postgraduate Program in Genetics, Department of Genetics, Federal University of Paran\u00e1 (UFPR), Curitiba 81531-980, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Braun-Prado","sequence":"additional","affiliation":[{"name":"Laboratory of Human Molecular Genetics, Department of Genetics, Federal University of Paran\u00e1 (UFPR), Curitiba 81531-980, Brazil"},{"name":"Postgraduate Program in Genetics, Department of Genetics, Federal University of Paran\u00e1 (UFPR), Curitiba 81531-980, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Wittig","sequence":"additional","affiliation":[{"name":"Institute of Clinical Molecular Biology (IKMB), Christian-Albrechts-University of Kiel, 24105 Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre","family":"Franke","sequence":"additional","affiliation":[{"name":"Institute of Clinical Molecular Biology (IKMB), Christian-Albrechts-University of Kiel, 24105 Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0384-114X","authenticated-orcid":false,"given":"Claudia","family":"Pf\u00f6hler","sequence":"additional","affiliation":[{"name":"Saarland University Medical Center, Department of Dermatology, 66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3449-1245","authenticated-orcid":false,"given":"Margitta","family":"Worm","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Dermatology, Venerology and Allergy, Charit\u00e9-Universit\u00e4tsmedizin Berlin, 10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"van Beek","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of L\u00fcbeck, 23562 L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Goebeler","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, University Hospital W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"S\u00e1rdy","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, University Hospital, LMU Munich, 80539 Munich, Germany"},{"name":"Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saleh","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates"},{"name":"L\u00fcbeck Institute of Experimental Dermatology (LIED), University of L\u00fcbeck, 23562 L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4763-4521","authenticated-orcid":false,"given":"Hauke","family":"Busch","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology (LIED), University of L\u00fcbeck, 23562 L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enno","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of L\u00fcbeck, 23562 L\u00fcbeck, Germany"},{"name":"L\u00fcbeck Institute of Experimental Dermatology (LIED), University of L\u00fcbeck, 23562 L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer Elisabeth","family":"Hundt","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology (LIED), University of L\u00fcbeck, 23562 L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4489-9148","authenticated-orcid":false,"given":"Patr\u00edcia Savio de","family":"Araujo-Souza","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics and Histocompatibility, Department of Genetics, Federal University of Paran\u00e1, Curitiba 81531-980, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0345-5276","authenticated-orcid":false,"given":"Maria Luiza","family":"Petzl-Erler","sequence":"additional","affiliation":[{"name":"Laboratory of Human Molecular Genetics, Department of Genetics, Federal University of Paran\u00e1 (UFPR), Curitiba 81531-980, Brazil"},{"name":"Postgraduate Program in Genetics, Department of Genetics, Federal University of Paran\u00e1 (UFPR), Curitiba 81531-980, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0140-6736(19)31778-7","article-title":"Pemphigus","volume":"394","author":"Schmidt","year":"2019","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00403-014-1531-1","article-title":"Geographic Variations in Epidemiology of Two Autoimmune Bullous Diseases: Pemphigus and Bullous Pemphigoid","volume":"307","author":"Alpsoy","year":"2015","journal-title":"Arch. Dermatol. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"100004","DOI":"10.1016\/j.xjidi.2021.100004","article-title":"Epidemiology of Pemphigus","volume":"1","author":"Kridin","year":"2021","journal-title":"JID Innov."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1087-0024.2004.00833.x","article-title":"Environmental Risk Factors in Endemic Pemphigus Foliaceus (Fogo Selvagem)","volume":"9","author":"Aoki","year":"2004","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e20190369","DOI":"10.1590\/1678-4685-gmb-2019-0369","article-title":"Beyond the HLA Polymorphism: A Complex Pattern of Genetic Susceptibility to Pemphigus","volume":"43","year":"2020","journal-title":"Genet. Mol. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0738-081X(98)00010-8","article-title":"Drug-Induced Pemphigus","volume":"16","author":"Brenner","year":"1998","journal-title":"Clin. Dermatol."},{"key":"ref_7","unstructured":"Pile, H.D., Yarrarapu, S.N.S., and Crane, J.S. (2021). Drug Induced Pemphigus. StatPearls, StatPearls Publishing."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.clindermatol.2013.01.004","article-title":"Pemphigus: Etiology, Pathogenesis, and Inducing or Triggering Factors: Facts and Controversies","volume":"31","author":"Ruocco","year":"2013","journal-title":"Clin. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00403-017-1790-8","article-title":"Pemphigus Trigger Factors: Special Focus on Pemphigus Vulgaris and Pemphigus Foliaceus","volume":"310","author":"Tavakolpour","year":"2018","journal-title":"Arch. Dermatol. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/1523-1747.ep12456932","article-title":"Environmental Risk Factors in Endemic Pemphigus Foliaceus (Fogo Selvagem). The Cooperative Group on Fogo Selvagem Research","volume":"98","author":"Lombardi","year":"1992","journal-title":"J. Investig. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.actatropica.2017.09.015","article-title":"Insights into the Epidemiological Link between Biting Flies and Pemphigus Foliaceus in Southeastern Brazil","volume":"176","author":"Vernal","year":"2017","journal-title":"Acta Trop."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.autrev.2016.07.005","article-title":"Non-Infectious Environmental Antigens as a Trigger for the Initiation of an Autoimmune Skin Disease","volume":"15","author":"Qian","year":"2016","journal-title":"Autoimmun. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1046\/j.1365-2133.1999.03201.x","article-title":"Detection of Herpesvirus DNA in Peripheral Blood Mononuclear Cells and Skin Lesions of Patients with Pemphigus by Polymerase Chain Reaction","volume":"141","author":"Tufano","year":"1999","journal-title":"Br. J. Dermatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/exd.13342","article-title":"Herpes Simplex Virus 1 and Cytomegalovirus Are Associated with Pemphigus Vulgaris but Not with Pemphigus Foliaceus Disease","volume":"26","author":"Machado","year":"2017","journal-title":"Exp. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.5501\/wjv.v9.i5.67","article-title":"Thymosin Alpha 1: A Comprehensive Review of the Literature","volume":"9","author":"Dominari","year":"2020","journal-title":"World J. Virol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1365-2133.1986.tb05710.x","article-title":"Elevated Thymosin Alpha I Levels in Brazilian Pemphigus Foliaceus","volume":"115","author":"Roscoe","year":"1986","journal-title":"Br. J. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/imr.12091","article-title":"Virus Infection, Antiviral Immunity, and Autoimmunity","volume":"255","author":"Getts","year":"2013","journal-title":"Immunol. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"587380","DOI":"10.3389\/fimmu.2020.587380","article-title":"Epstein-Barr Virus and Systemic Autoimmune Diseases","volume":"11","author":"Houen","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"102781","DOI":"10.1016\/j.jaut.2021.102781","article-title":"Genetic and Transcriptomic Analyses Support a Switch to Lytic Phase in Epstein Barr Virus Infection as an Important Driver in Developing Systemic Lupus Erythematosus","volume":"127","author":"Afrasiabi","year":"2022","journal-title":"J. Autoimmun."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Kraberger, S., Schmidlin, K., Fontenele, R.S., Walters, M., and Varsani, A. (2019). Unravelling the Single-Stranded DNA Virome of the New Zealand Blackfly. Viruses, 11.","DOI":"10.3390\/v11060532"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Lu, G., Ye, Z.-X., He, Y.-J., Zhang, Y., Wang, X., Huang, H.-J., Zhuo, J.-C., Sun, Z.-T., Yan, F., and Chen, J.-P. (2020). Discovery of Two Novel Negeviruses in a Dungfly Collected from the Arctic. Viruses, 12.","DOI":"10.3390\/v12070692"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1093\/jme\/tjaa193","article-title":"Discovery of a Novel Flavivirus (Flaviviridae) From the Horse Fly, Tabanus Rufidens (Diptera: Tabanidae): The Possible Coevolutionary Relationships Between the Classical Insect-Specific Flaviviruses and Host Dipteran Insects","volume":"58","author":"Kobayashi","year":"2021","journal-title":"J. Med. Entomol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e00039-20","DOI":"10.1128\/mSystems.00039-20","article-title":"Abundant and Diverse RNA Viruses in Insects Revealed by RNA-Seq Analysis: Ecological and Evolutionary Implications","volume":"5","author":"Wu","year":"2020","journal-title":"mSystems"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e20190122","DOI":"10.1590\/0001-3765201920190122","article-title":"The Insect Reservoir of Biodiversity for Viruses and for Antiviral Mechanisms","volume":"91","author":"Olmo","year":"2019","journal-title":"An. Acad. Bras. Cienc."},{"key":"ref_25","unstructured":"Green, M.R., Sambrook, J., and Sambrook, J. (2012). Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press. [4th ed.]."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/imm.13259","article-title":"Variation in Genes Implicated in B-Cell Development and Antibody Production Affects Susceptibility to Pemphigus","volume":"162","author":"Amorim","year":"2021","journal-title":"Immunology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1111\/jdv.16752","article-title":"Updated S2K Guidelines on the Management of Pemphigus Vulgaris and Foliaceus Initiated by the European Academy of Dermatology and Venereology (EADV)","volume":"34","author":"Joly","year":"2020","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"102705","DOI":"10.1016\/j.jaut.2021.102705","article-title":"Genetic Association and Differential Expression of HLA Complex Group LncRNAs in Pemphigus","volume":"123","author":"Becker","year":"2021","journal-title":"J. Autoimmun."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/978-1-4939-6783-4_11","article-title":"Functional Interaction Network Construction and Analysis for Disease Discovery","volume":"1558","author":"Wu","year":"2017","journal-title":"Methods Mol. Biol. Clifton NJ"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1074\/mcp.TIR120.002155","article-title":"ReactomeGSA-Efficient Multi-Omics Comparative Pathway Analysis","volume":"19","author":"Griss","year":"2020","journal-title":"Mol. Cell. Proteom. MCP"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1016\/j.jid.2021.04.017","article-title":"Unsuspected Associations of Variants within the Genes NOTCH4 and STEAP2-AS1 Uncovered by a GWAS in Endemic Pemphigus Foliaceus","volume":"141","author":"Augusto","year":"2021","journal-title":"J. Investig. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"695","DOI":"10.3389\/fimmu.2018.00695","article-title":"Sparking Fire Under the Skin? Answers From the Association of Complement Genes With Pemphigus Foliaceus","volume":"9","author":"Cipolla","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.3389\/fimmu.2019.02416","article-title":"Condemned or Not to Die? Gene Polymorphisms Associated with Cell Death in Pemphigus Foliaceus","volume":"10","author":"Cipolla","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41562-017-0189-z","article-title":"Redefine Statistical Significance","volume":"2","author":"Benjamin","year":"2018","journal-title":"Nat. Hum. Behav."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1001\/jama.2018.1536","article-title":"The Proposal to Lower P Value Thresholds to 0.005","volume":"319","author":"Ioannidis","year":"2018","journal-title":"JAMA"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s41747-020-0145-y","article-title":"Statistical Significance: P Value, 0.05 Threshold, and Applications to Radiomics-Reasons for a Conservative Approach","volume":"4","author":"Sardanelli","year":"2020","journal-title":"Eur. Radiol. Exp."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1002\/cpz1.90","article-title":"Gene Set Knowledge Discovery with Enrichr","volume":"1","author":"Xie","year":"2021","journal-title":"Curr. Protoc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3558","DOI":"10.1093\/nar\/gkq1313","article-title":"Wide-Ranging Functions of E2F4 in Transcriptional Activation and Repression Revealed by Genome-Wide Analysis","volume":"39","author":"Lee","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/imm.12315","article-title":"Genome-Wide Gene Expression Profiling Reveals Unsuspected Molecular Alterations in Pemphigus Foliaceus","volume":"143","author":"Malheiros","year":"2014","journal-title":"Immunology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"632798","DOI":"10.3389\/fimmu.2021.632798","article-title":"Comprehensive Transcriptomic Analysis Identifies Novel Antiviral Factors Against Influenza A Virus Infection","volume":"12","author":"Zhou","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.3389\/fimmu.2018.03047","article-title":"IRF and STAT Transcription Factors-From Basic Biology to Roles in Infection, Protective Immunity, and Primary Immunodeficiencies","volume":"9","author":"Mogensen","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"eabe1194","DOI":"10.1126\/scisignal.abe1194","article-title":"ETV7 Limits Antiviral Gene Expression and Control of Influenza Viruses","volume":"14","author":"Froggatt","year":"2021","journal-title":"Sci. Signal."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1001\/archderm.1940.01490110044006","article-title":"Pemphigus foliaceus (fogo salvagem): An endemic disease of the state of s\u00e3o paulo (Brazil)","volume":"41","author":"Vieira","year":"1940","journal-title":"Arch. Dermatol. Syphilol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"102561","DOI":"10.1016\/j.jaut.2020.102561","article-title":"Identification of a Primary Antigenic Target of Epitope Spreading in Endemic Pemphigus Foliaceus","volume":"116","author":"Peng","year":"2021","journal-title":"J. Autoimmun."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"17664","DOI":"10.1038\/s41598-020-74343-y","article-title":"RNA-Sequencing of the Nyssomyia Neivai Sialome: A Sand Fly-Vector from a Brazilian Endemic Area for Tegumentary Leishmaniasis and Pemphigus Foliaceus","volume":"10","author":"Vernal","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bpg.2018.06.001","article-title":"Is PBC a Viral Infectious Disease?","volume":"34\u201335","author":"Mason","year":"2018","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"623944","DOI":"10.3389\/fimmu.2020.623944","article-title":"Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus","volume":"11","author":"Jog","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"17965","DOI":"10.1073\/pnas.1922366117","article-title":"Human TRIM5\u03b1 Senses and Restricts LINE-1 Elements","volume":"117","author":"Volkmann","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/s41579-019-0225-2","article-title":"Restriction of HIV-1 and Other Retroviruses by TRIM5","volume":"17","author":"Pornillos","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1016\/j.celrep.2019.05.040","article-title":"TRIM5\u03b1 Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation","volume":"27","author":"Chiramel","year":"2019","journal-title":"Cell Rep."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Rose, K.M., Spada, S.J., Broeckel, R., McNally, K.L., Hirsch, V.M., Best, S.M., and Bouamr, F. (2021). From Capsids to Complexes: Expanding the Role of TRIM5\u03b1 in the Restriction of Divergent RNA Viruses and Elements. Viruses, 13.","DOI":"10.3390\/v13030446"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e01541-17","DOI":"10.1128\/JVI.01541-17","article-title":"The Three-Fold Axis of the HIV-1 Capsid Lattice Is the Species-Specific Binding Interface for TRIM5\u03b1","volume":"92","author":"Morger","year":"2018","journal-title":"J. Virol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s12967-016-1005-7","article-title":"Relationship of TRIM5 and TRIM22 Polymorphisms with Liver Disease and HCV Clearance after Antiviral Therapy in HIV\/HCV Coinfected Patients","volume":"14","author":"Medrano","year":"2016","journal-title":"J. Transl. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.gene.2018.07.023","article-title":"Evaluation of TRIM5 and TRIM22 Polymorphisms on Treatment Responses in Iranian Patients with Chronic Hepatitis C Virus Infection","volume":"676","author":"Mobasheri","year":"2018","journal-title":"Gene"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/rmv.465","article-title":"Association of Human Endogenous Retroviruses with Multiple Sclerosis and Possible Interactions with Herpes Viruses","volume":"15","author":"Christensen","year":"2005","journal-title":"Rev. Med. Virol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Nex\u00f8, B.A., Christensen, T., Frederiksen, J., M\u00f8ller-Larsen, A., Oturai, A.B., Villesen, P., Hansen, B., Nissen, K.K., Laska, M.J., and Petersen, T.S. (2011). The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0016652"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"648629","DOI":"10.3389\/fnins.2021.648629","article-title":"Viruses and Endogenous Retroviruses as Roots for Neuroinflammation and Neurodegenerative Diseases","volume":"15","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Nex\u00f8, B.A., Hansen, B., Nissen, K.K., Gundestrup, L., Terkelsen, T., Villesen, P., Bahrami, S., Petersen, T., Pedersen, F.S., and Laska, M.J. (2013). Restriction Genes for Retroviruses Influence the Risk of Multiple Sclerosis. PLoS ONE, 8.","DOI":"10.1371\/annotation\/81edbe21-6549-474d-b456-540e0662c6b8"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Xu, W.K., Byun, H., and Dudley, J.P. (2020). The Role of APOBECs in Viral Replication. Microorganisms, 8.","DOI":"10.20944\/preprints202011.0013.v1"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/683095","article-title":"The Role of Cytidine Deaminases on Innate Immune Responses against Human Viral Infections","volume":"2013","author":"Vieira","year":"2013","journal-title":"BioMed. Res. Int."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/nature00939","article-title":"Isolation of a Human Gene That Inhibits HIV-1 Infection and Is Suppressed by the Viral Vif Protein","volume":"418","author":"Sheehy","year":"2002","journal-title":"Nature"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"53379","DOI":"10.1074\/jbc.M408802200","article-title":"APOBEC3B and APOBEC3C Are Potent Inhibitors of Simian Immunodeficiency Virus Replication","volume":"279","author":"Yu","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.virol.2015.03.012","article-title":"APOBECs and Virus Restriction","volume":"479\u2013480","author":"Harris","year":"2015","journal-title":"Virology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nature03238","article-title":"APOBEC3G Cytidine Deaminase Inhibits Retrotransposition of Endogenous Retroviruses","volume":"433","author":"Esnault","year":"2005","journal-title":"Nature"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"7893","DOI":"10.1038\/s41598-021-87024-1","article-title":"Sustained High Expression of Multiple APOBEC3 Cytidine Deaminases in Systemic Lupus Erythematosus","volume":"11","author":"Laude","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"108649","DOI":"10.1016\/j.clim.2020.108649","article-title":"Expression of APOBEC Family Members as Regulators of Endogenous Retroelements and Malignant Transformation in Systemic Autoimmunity","volume":"223","author":"Mavragani","year":"2021","journal-title":"Clin. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nature08030","article-title":"NAADP Mobilizes Calcium from Acidic Organelles through Two-Pore Channels","volume":"459","author":"Calcraft","year":"2009","journal-title":"Nature"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fphar.2017.00045","article-title":"Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function","volume":"8","author":"Grimm","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1126\/science.1258758","article-title":"Ebola Virus. Two-Pore Channels Control Ebola Virus Host Cell Entry and Are Drug Targets for Disease Treatment","volume":"347","author":"Sakurai","year":"2015","journal-title":"Science"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ceca.2018.08.003","article-title":"NAADP-Dependent Ca2+ Signaling Regulates Middle East Respiratory Syndrome-Coronavirus Pseudovirus Translocation through the Endolysosomal System","volume":"75","author":"Gunaratne","year":"2018","journal-title":"Cell Calcium"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1038\/s41467-020-15562-9","article-title":"Characterization of Spike Glycoprotein of SARS-CoV-2 on Virus Entry and Its Immune Cross-Reactivity with SARS-CoV","volume":"11","author":"Ou","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/gene.2013.44","article-title":"Genome-Wide Expression Analysis Suggests Unique Disease-Promoting and Disease-Preventing Signatures in Pemphigus Vulgaris","volume":"14","author":"Sinha","year":"2013","journal-title":"Genes Immun."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Chen, S., Feng, C., Fang, Y., Zhou, X., Xu, L., Wang, W., Kong, X., Peppelenbosch, M.P., Pan, Q., and Yin, Y. (2019). The Eukaryotic Translation Initiation Factor 4F Complex Restricts Rotavirus Infection via Regulating the Expression of IRF1 and IRF7. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20071580"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1093\/annonc\/mdx412","article-title":"Impact of Genetic Variations in the MAPK Signaling Pathway on Outcome in Metastatic Colorectal Cancer Patients Treated with First-Line FOLFIRI and Bevacizumab: Data from FIRE-3 and TRIBE Trials","volume":"28","author":"Berger","year":"2017","journal-title":"Ann. Oncol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.tibs.2016.05.009","article-title":"A Cap for Every Occasion: Alternative EIF4F Complexes","volume":"41","author":"Ho","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"8562","DOI":"10.1093\/nar\/gkaa646","article-title":"RNA-Tethering Assay and EIF4G:EIF4A Obligate Dimer Design Uncovers Multiple EIF4F Functional Complexes","volume":"48","author":"Robert","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"6381","DOI":"10.1128\/JVI.00078-11","article-title":"Blocking EIF4E-EIF4G Interaction as a Strategy To Impair Coronavirus Replication","volume":"85","author":"Cencic","year":"2011","journal-title":"J. Virol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1101\/gad.1185304","article-title":"Phosphorylation of EIF4E by Mnk-1 Enhances HSV-1 Translation and Replication in Quiescent Cells","volume":"18","author":"Walsh","year":"2004","journal-title":"Genes Dev."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1042\/BST0381511","article-title":"Manipulation of the Host Translation Initiation Complex EIF4F by DNA Viruses","volume":"38","author":"Walsh","year":"2010","journal-title":"Biochem. Soc. Trans."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.virol.2011.10.028","article-title":"Influenza Virus Polymerase Confers Independence of the Cellular Cap-Binding Factor EIF4E for Viral MRNA Translation","volume":"422","author":"Rodriguez","year":"2012","journal-title":"Virology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.virol.2013.06.008","article-title":"Translation of Viral MRNAs That Do Not Require EIF4E Is Blocked by the Inhibitor 4EGI-1","volume":"444","author":"Redondo","year":"2013","journal-title":"Virology"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"10177","DOI":"10.1128\/JVI.76.20.10177-10187.2002","article-title":"Vesicular Stomatitis Virus Infection Alters the EIF4F Translation Initiation Complex and Causes Dephosphorylation of the EIF4E Binding Protein 4E-BP1","volume":"76","author":"Connor","year":"2002","journal-title":"J. Virol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/ni.2291","article-title":"Translational Control of the Activation of Transcription Factor NF-\u039aB and Production of Type I Interferon by Phosphorylation of the Translation Factor EIF4E","volume":"13","author":"Herdy","year":"2012","journal-title":"Nat. Immunol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1590\/S0100-879X2009001100004","article-title":"Dengue Virus-Induced Regulation of the Host Cell Translational Machinery","volume":"42","author":"Santoro","year":"2009","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1365-2249.2004.02432.x","article-title":"The Nuclear Pore Complex Protein Tpr Is a Common Autoantigen in Sera That Demonstrate Nuclear Envelope Staining by Indirect Immunofluorescence","volume":"136","author":"Ou","year":"2004","journal-title":"Clin. Exp. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00109-004-0554-z","article-title":"Autoantigens of the Nuclear Pore Complex","volume":"82","author":"Enarson","year":"2004","journal-title":"J. Mol. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.autrev.2012.03.005","article-title":"Primary Biliary Cirrhosis and the Nuclear Pore Complex","volume":"11","author":"Bogdanos","year":"2012","journal-title":"Autoimmun. Rev."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"The RACI Consortium, The GARNET Consortium, Okada, Y., Wu, D., Trynka, G., Raj, T., Terao, C., Ikari, K., Kochi, Y., and Ohmura, K. (2014). Genetics of Rheumatoid Arthritis Contributes to Biology and Drug Discovery. Nature, 506, 376\u2013381.","DOI":"10.1038\/nature12873"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1093\/hmg\/ddy395","article-title":"Genetic Influences on Susceptibility to Rheumatoid Arthritis in African-Americans","volume":"28","author":"Laufer","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.3390\/v5082019","article-title":"Viral Subversion of the Nuclear Pore Complex","volume":"5","author":"Mouland","year":"2013","journal-title":"Viruses"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Wubben, J.M., Atkinson, S.C., and Borg, N.A. (2020). The Role of Protein Disorder in Nuclear Transport and in Its Subversion by Viruses. Cells, 9.","DOI":"10.3390\/cells9122654"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"De Jes\u00fas-Gonz\u00e1lez, L.A., Palacios-R\u00e1palo, S., Reyes-Ruiz, J.M., Osuna-Ramos, J.F., Cordero-Rivera, C.D., Farfan-Morales, C.N., Guti\u00e9rrez-Escolano, A.L., and del \u00c1ngel, R.M. (2021). The Nuclear Pore Complex Is a Key Target of Viral Proteases to Promote Viral Replication. Viruses, 13.","DOI":"10.3390\/v13040706"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"9702","DOI":"10.1128\/JVI.01669-15","article-title":"Impact of Nucleoporin-Mediated Chromatin Localization and Nuclear Architecture on HIV Integration Site Selection","volume":"89","author":"Wong","year":"2015","journal-title":"J. Virol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00705-020-04899-7","article-title":"Hsa-MiR-191-5p Inhibits Replication of Human Immunodeficiency Virus Type 1 by Downregulating the Expression of NUP50","volume":"166","author":"Zheng","year":"2021","journal-title":"Arch. Virol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1743-422X-9-77","article-title":"Screening and Functional Analysis of Differentially Expressed Genes in EBV-Transformed Lymphoblasts","volume":"9","author":"Dai","year":"2012","journal-title":"Virol. J."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Das, T., Song, E.J., and Kim, E.E. (2021). The Multifaceted Roles of USP15 in Signal Transduction. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094728"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"ra3","DOI":"10.1126\/scisignal.2004577","article-title":"The Ubiquitin-Specific Protease USP15 Promotes RIG-I-Mediated Antiviral Signaling by Deubiquitylating TRIM25","volume":"7","author":"Pauli","year":"2014","journal-title":"Sci. Signal."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/ni.3581","article-title":"USP15 Regulates Type I Interferon Response and Is Required for Pathogenesis of Neuroinflammation","volume":"18","author":"Torre","year":"2017","journal-title":"Nat. Immunol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e01737-17","DOI":"10.1128\/JVI.01737-17","article-title":"The Human Papillomavirus E6 Oncoprotein Targets USP15 and TRIM25 To Suppress RIG-I-Mediated Innate Immune Signaling","volume":"92","author":"Chiang","year":"2018","journal-title":"J. Virol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.virusres.2016.07.009","article-title":"Function of Ubiquitin (Ub) Specific Protease 15 (USP15) in HIV-1 Replication and Viral Protein Degradation","volume":"223","author":"Pyeon","year":"2016","journal-title":"Virus Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e01708-18","DOI":"10.1128\/JVI.01708-18","article-title":"USP15 Participates in Hepatitis C Virus Propagation through Regulation of Viral RNA Translation and Lipid Droplet Formation","volume":"93","author":"Kusakabe","year":"2019","journal-title":"J. Virol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.4049\/jimmunol.1600548","article-title":"Ubiquitination of ROR\u03b3t at Lysine 446 Limits Th17 Differentiation by Controlling Coactivator Recruitment","volume":"197","author":"He","year":"2016","journal-title":"J. Immunol."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Paiva, I.A., Badolato-Corr\u00eaa, J., Familiar-Macedo, D., and de-Oliveira-Pinto, L.M. (2021). Th17 Cells in Viral Infections-Friend or Foe?. Cells, 10.","DOI":"10.3390\/cells10051159"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Wacleche, V.S., Landay, A., Routy, J.-P., and Ancuta, P. (2017). The Th17 Lineage: From Barrier Surfaces Homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis. Viruses, 9.","DOI":"10.3390\/v9100303"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Fraternale, A., Zara, C., De Angelis, M., Nencioni, L., Palamara, A.T., Retini, M., Di Mambro, T., Magnani, M., and Crinelli, R. (2021). Intracellular Redox-Modulated Pathways as Targets for Effective Approaches in the Treatment of Viral Infection. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073603"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"107664","DOI":"10.1016\/j.exer.2019.05.004","article-title":"Quantitative Proteomic Analysis of Human Corneal Epithelial Cells Infected with HSV-1","volume":"185","author":"Cui","year":"2019","journal-title":"Exp. Eye Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"989","DOI":"10.4269\/ajtmh.14-0162","article-title":"Correlation between Serum Levels of Anti-Endothelial Cell Autoantigen and Anti-Dengue Virus Nonstructural Protein 1 Antibodies in Dengue Patients","volume":"92","author":"Cheng","year":"2015","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"656090","DOI":"10.3389\/fimmu.2021.656090","article-title":"A Novel Autoantibody Induced by Bacterial Biofilm Conserved Components Aggravates Lupus Nephritis","volume":"12","author":"Fu","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1468-1331.2004.00951.x","article-title":"The Levels of Chemokines CXCL8, CCL2 and CCL5 in Multiple Sclerosis Patients Are Linked to the Activity of the Disease","volume":"12","author":"Stelmasiak","year":"2005","journal-title":"Eur. J. Neurol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1055\/s-2008-1073153","article-title":"Chemokines and Autoimmune Thyroid Diseases","volume":"40","author":"Liu","year":"2008","journal-title":"Horm. Metab. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1126\/science.270.5243.1811","article-title":"Identification of RANTES, MIP-1\u03b1, and MIP-1\u03b2 as the Major HIV-Suppressive Factors Produced by CD8+ T Cells","volume":"270","author":"Cocchi","year":"1995","journal-title":"Science"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1182\/blood-2011-11-390153","article-title":"Engagement of NKp30 on V\u03b41 T Cells Induces the Production of CCL3, CCL4, and CCL5 and Suppresses HIV-1 Replication","volume":"119","author":"Hudspeth","year":"2012","journal-title":"Blood"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"549020","DOI":"10.3389\/fcimb.2021.549020","article-title":"The Chemokine CCL5 Inhibits the Replication of Influenza A Virus Through SAMHD1 Modulation","volume":"11","author":"Silva","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3109\/08830185.2011.593105","article-title":"CCL5: A Double-Edged Sword in Host Defense Against the Hepatitis C Virus","volume":"30","author":"Katsounas","year":"2011","journal-title":"Int. Rev. Immunol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"709","DOI":"10.4269\/ajtmh.14-0745","article-title":"Association of Chemotactic Chemokine Ligand 5 Polymorphisms with the Risk of Developing Severe Enterovirus 71 Infection","volume":"93","author":"Li","year":"2015","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1177\/1753425919891662","article-title":"Association of Chemotactic Chemokine Ligand 5 Rs2107538 Polymorphism with Tuberculosis Susceptibility: A Meta-Analysis","volume":"26","author":"Sheng","year":"2020","journal-title":"Innate Immun."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/ng.401","article-title":"Meta-Analysis of Genome Scans and Replication Identify CD6, IRF8 and TNFRSF1A as New Multiple Sclerosis Susceptibility Loci","volume":"41","author":"Jia","year":"2009","journal-title":"Nat. Genet."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"International Multiple Sclerosis Genetics Consortium (2011). The Genetic Association of Variants in CD6, TNFRSF1A and IRF8 to Multiple Sclerosis: A Multicenter Case-Control Study. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0018813"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Gorlova, O., Martin, J.-E., Rueda, B., Koeleman, B.P.C., Ying, J., Teruel, M., Diaz-Gallo, L.-M., Broen, J.C., Vonk, M.C., and Simeon, C.P. (2011). Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy. PLoS Genet., 7.","DOI":"10.1371\/annotation\/7a52649c-0942-4bd8-a5d3-3cdacca03cd8"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13075-015-0572-y","article-title":"Identification of NF-\u039aB and PLCL2 as New Susceptibility Genes and Highlights on a Potential Role of IRF8 through Interferon Signature Modulation in Systemic Sclerosis","volume":"17","author":"Arismendi","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"19651","DOI":"10.1038\/srep19651","article-title":"Two Genetic Variations in the IRF8 Region Are Associated with Beh\u00e7et\u2019s Disease in Han Chinese","volume":"6","author":"Jiang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.3389\/fimmu.2017.01992","article-title":"Gene Expression Analysis Reveals Novel Shared Gene Signatures and Candidate Molecular Mechanisms between Pemphigus and Systemic Lupus Erythematosus in CD4+ T Cells","volume":"8","author":"Sezin","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.immuni.2012.03.013","article-title":"The JAK-STAT Pathway at Twenty","volume":"36","author":"Stark","year":"2012","journal-title":"Immunity"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/4143604","article-title":"Noncanonical IFN Signaling, Steroids, and STATs: A Probable Role of V-ATPase","volume":"2019","author":"Johnson","year":"2019","journal-title":"Mediat. Inflamm."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41586-020-2436-0","article-title":"FLT3 Stop Mutation Increases FLT3 Ligand Level and Risk of Autoimmune Thyroid Disease","volume":"584","author":"Saevarsdottir","year":"2020","journal-title":"Nature"},{"key":"ref_127","unstructured":"International Multiple Sclerosis Genetics Consortium, Patsopoulos, N.A., Baranzini, S.E., Santaniello, A., Shoostari, P., Cotsapas, C., Wong, G., Beecham, A.H., James, T., and Replogle, J. (2019). Multiple Sclerosis Genomic Map Implicates Peripheral Immune Cells and Microglia in Susceptibility. Science, 365, eaav7188."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000509880","article-title":"JAK1 Rs310241 and JAK3 Rs3008 Genotypes May Increase Susceptibility to Psoriasis: A Case Control Study","volume":"33","author":"Sayed","year":"2020","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/cei.12888","article-title":"A Preliminary Study of New Single Polymorphisms in the T Helper Type 17 Pathway for Psoriasis in the Korean Population","volume":"187","author":"Kim","year":"2017","journal-title":"Clin. Exp. Immunol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s00439-013-1312-5","article-title":"Genetic Variants in the JAK1 Gene Confer Higher Risk of Behcet\u2019s Disease with Ocular Involvement in Han Chinese","volume":"132","author":"Hou","year":"2013","journal-title":"Hum. Genet."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1167\/iovs.13-11615","article-title":"JAK1, but Not JAK2 and STAT3, Confers Susceptibility to Vogt\u2013Koyanagi\u2013Harada (VKH) Syndrome in a Han Chinese Population","volume":"54","author":"Hu","year":"2013","journal-title":"Investig. Opthalmology Vis. Sci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ajhg.2018.11.008","article-title":"Leveraging Polygenic Functional Enrichment to Improve GWAS Power","volume":"104","author":"Kichaev","year":"2019","journal-title":"Am. J. Hum. Genet."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"eabg0833","DOI":"10.1126\/sciimmunol.abg0833","article-title":"SARS-CoV-2 Drives JAK1\/2-Dependent Local Complement Hyperactivation","volume":"6","author":"Yan","year":"2021","journal-title":"Sci. Immunol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12985-020-01348-4","article-title":"Influenza a Virus Antagonizes Type I and Type II Interferon Responses via SOCS1-Dependent Ubiquitination and Degradation of JAK1","volume":"17","author":"Du","year":"2020","journal-title":"Virol. J."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"106754","DOI":"10.1016\/j.intimp.2020.106754","article-title":"Inhibition of MiR-93 Promotes Interferon Effector Signaling to Suppress Influenza A Infection by Upregulating JAK1","volume":"86","author":"Guo","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1089\/jir.2009.0064","article-title":"Multifaceted Evasion of the Interferon Response by Cytomegalovirus","volume":"29","author":"Marshall","year":"2009","journal-title":"J. Interferon Cytokine Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"e01161-18","DOI":"10.1128\/JVI.01161-18","article-title":"Herpes Simplex Virus 1 UL36USP Antagonizes Type I Interferon-Mediated Antiviral Innate Immunity","volume":"92","author":"Yuan","year":"2018","journal-title":"J. Virol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/1873-3468.13670","article-title":"Respirovirus C Protein Inhibits Activation of Type I Interferon Receptor-associated Kinases to Block JAK-STAT Signaling","volume":"594","author":"Kitagawa","year":"2020","journal-title":"FEBS Lett."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.smim.2008.06.003","article-title":"The Yin and Yang of HLA and KIR in Human Disease","volume":"20","author":"Kulkarni","year":"2008","journal-title":"Semin. Immunol."},{"key":"ref_140","first-page":"112","article-title":"Natural Killer Cells in Antiviral Immunity","volume":"22","author":"Strunz","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Augusto, D.G., Lobo-Alves, S.C., Melo, M.F., Pereira, N.F., and Petzl-Erler, M.L. (2012). Activating KIR and HLA Bw4 Ligands Are Associated to Decreased Susceptibility to Pemphigus Foliaceus, an Autoimmune Blistering Skin Disease. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0039991"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1002\/eji.201445324","article-title":"Pemphigus Is Associated with KIR3DL2 Expression Levels and Provides Evidence That KIR3DL2 May Bind HLA-A3 and A11 in Vivo: Innate Immunity","volume":"45","author":"Augusto","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Feng, H., Zhang, Y.-B., Gui, J.-F., Lemon, S.M., and Yamane, D. (2021). Interferon Regulatory Factor 1 (IRF1) and Anti-Pathogen Innate Immune Responses. PLoS Pathog., 17.","DOI":"10.1371\/journal.ppat.1009220"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature09907","article-title":"A Diverse Range of Gene Products Are Effectors of the Type I Interferon Antiviral Response","volume":"472","author":"Schoggins","year":"2011","journal-title":"Nature"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"e01706-16","DOI":"10.1128\/JVI.01706-16","article-title":"RPLP1 and RPLP2 Are Essential Flavivirus Host Factors That Promote Early Viral Protein Accumulation","volume":"91","author":"Campos","year":"2017","journal-title":"J. Virol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"8736","DOI":"10.1074\/jbc.M702186200","article-title":"Evidence of Key Role of Cdk2 Overexpression in Pemphigus Vulgaris","volume":"283","author":"Lanza","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1038\/jid.2012.46","article-title":"Population-Specific Association between a Polymorphic Variant in ST18, Encoding a Pro-Apoptotic Molecule, and Pemphigus Vulgaris","volume":"132","author":"Sarig","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1074\/jbc.M309000200","article-title":"Pemphigus Vulgaris IgG and Methylprednisolone Exhibit Reciprocal Effects on Keratinocytes","volume":"279","author":"Nguyen","year":"2004","journal-title":"J. Biol. Chem."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/5\/879\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:59:28Z","timestamp":1760137168000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/5\/879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,23]]},"references-count":148,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["v14050879"],"URL":"https:\/\/doi.org\/10.3390\/v14050879","relation":{},"ISSN":["1999-4915"],"issn-type":[{"type":"electronic","value":"1999-4915"}],"subject":[],"published":{"date-parts":[[2022,4,23]]}}}