{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:13:06Z","timestamp":1792120386854,"version":"4.4.0"},"reference-count":122,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32102635"],"award-info":[{"award-number":["32102635"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32172823"],"award-info":[{"award-number":["32172823"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["BK20210805"],"award-info":[{"award-number":["BK20210805"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Jiangsu Province","award":["32102635"],"award-info":[{"award-number":["32102635"]}]},{"name":"Natural Science Foundation of Jiangsu Province","award":["32172823"],"award-info":[{"award-number":["32172823"]}]},{"name":"Natural Science Foundation of Jiangsu Province","award":["BK20210805"],"award-info":[{"award-number":["BK20210805"]}]},{"name":"Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)","award":["32102635"],"award-info":[{"award-number":["32102635"]}]},{"name":"Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)","award":["32172823"],"award-info":[{"award-number":["32172823"]}]},{"name":"Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)","award":["BK20210805"],"award-info":[{"award-number":["BK20210805"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Pseudorabies virus (PRV), the causative agent of Aujeszky\u2019s disease, has a broad host range including most mammals and avian species. In 2011, a PRV variant emerged in many Bartha K61-vaccinated pig herds in China and has attracted more and more attention due to its serious threat to domestic and wild animals, and even human beings. The PRV variant has been spreading in China for more than 10 years, and considerable research progresses about its molecular biology, pathogenesis, transmission, and host\u2013virus interactions have been made. This review is mainly organized into four sections including outbreak and genomic evolution characteristics of PRV variants, progresses of PRV variant vaccine development, the pathogenicity and transmission of PRV variants among different species of animals, and the zoonotic potential of PRV variants. Considering PRV has caused a huge economic loss of animals and is a potential threat to public health, it is necessary to extensively explore the mechanisms involved in its replication, pathogenesis, and transmission in order to ultimately eradicate it in China.<\/jats:p>","DOI":"10.3390\/v14051003","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T23:39:36Z","timestamp":1652225976000},"page":"1003","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["A Review of Pseudorabies Virus Variants: Genomics, Vaccination, Transmission, and Zoonotic Potential"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5286-7405","authenticated-orcid":false,"given":"Zongyi","family":"Bo","sequence":"first","affiliation":[{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, China"},{"name":"Jiangsu Co-Innovation Center for the Prevention and Control of Animal Infectious Disease and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4635-1602","authenticated-orcid":false,"given":"Xiangdong","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Co-Innovation Center for the Prevention and Control of Animal Infectious Disease and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1128\/MMBR.69.3.462-500.2005","article-title":"Molecular Biology of Pseudorabies Virus: Impact on Neurovirology and Veterinary Medicine","volume":"69","author":"Pomeranz","year":"2005","journal-title":"Microbiol. 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