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Since there is a robust secretion of SARS-CoV-2-specific highly-neutralizing IgA antibodies in breast milk, and because this immunoglobulin plays an essential role against respiratory virus infection in mucosa cells, being, in addition, more potent in neutralizing SARS-CoV-2 than IgG, here we report the clinical course of an NF\u03baB-deficient patient chronically infected with the SARS-CoV-2 Gamma variant, who, after a non-full effective treatment with plasma infusion, received breast milk from a vaccinated mother by oral route as treatment for COVID-19. After such treatment, the symptoms improved, and the patient was systematically tested negative for SARS-CoV-2. Thus, we hypothesize that IgA and IgG secreted antibodies present in breast milk could be useful to treat persistent SARS-CoV-2 infection in immunodeficient patients.<\/jats:p>","DOI":"10.3390\/v14051042","type":"journal-article","created":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T09:48:22Z","timestamp":1652608102000},"page":"1042","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clearance of Persistent SARS-CoV-2 RNA Detection in a NF\u03baB-Deficient Patient in Association with the Ingestion of Human Breast Milk: A Case Report"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6502-1206","authenticated-orcid":false,"given":"Janine S.","family":"Sabino","sequence":"first","affiliation":[{"name":"Laboratory of Pediatric Immunology, Center for Investigation in Pediatrics, Faculty of Medical Sciences, University of Campinas, Campinas 13083-887, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8516-0155","authenticated-orcid":false,"given":"Mariene R.","family":"Amorim","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M.","family":"de Souza","sequence":"additional","affiliation":[{"name":"World Reference Center for Emerging Viruses, Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lia F.","family":"Marega","sequence":"additional","affiliation":[{"name":"Laboratory of Pediatric Immunology, Center for Investigation in Pediatrics, Faculty of Medical Sciences, University of Campinas, Campinas 13083-887, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana S.","family":"Mofatto","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4055-058X","authenticated-orcid":false,"given":"Daniel A.","family":"Toledo-Teixeira","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Forato","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0476-920X","authenticated-orcid":false,"given":"Rodrigo G.","family":"Stabeli","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Foundation (Fiocruz-SP), Ribeir\u00e3o Preto 14049-900, Brazil"},{"name":"Department of Public Health Emergency, Preparedness and Disaster, PAHO\/WHO, Brasilia 70312-970, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Laura","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Campinas, Campinas 13083-887, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5804-7045","authenticated-orcid":false,"given":"Fernando R.","family":"Spilki","sequence":"additional","affiliation":[{"name":"One Health Laboratory, Feevale University, Novo Hamburgo 93510-235, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ester C.","family":"Sabino","sequence":"additional","affiliation":[{"name":"Tropical Medicine Institute, Medical School, University of S\u00e3o Paulo, S\u00e3o Paulo 5403-907, Brazil"},{"name":"Department of Infectious and Parasitic Disease, Medical School, University of S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuno R.","family":"Faria","sequence":"additional","affiliation":[{"name":"Department of Infectious and Parasitic Disease, Medical School, University of S\u00e3o Paulo, S\u00e3o Paulo 05403-000, Brazil"},{"name":"Department of Zoology, University of Oxford, Oxford OX1 2JD, UK"},{"name":"MRC Centre for Global Infectious Disease Analysis, J-IDEA, Imperial College London, London SW7 2AZ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3985-5690","authenticated-orcid":false,"given":"Bruno D.","family":"Benites","sequence":"additional","affiliation":[{"name":"Hematology and Transfusion Medicine Center, University of Campinas, Campinas 13083-878, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0178-6191","authenticated-orcid":false,"given":"Marcelo","family":"Addas-Carvalho","sequence":"additional","affiliation":[{"name":"Hematology and Transfusion Medicine Center, University of Campinas, Campinas 13083-878, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel S. 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Commun."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1099\/vir.0.81579-0","article-title":"Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidatesin mice challenged with SARS coronavirus","volume":"87","author":"See","year":"2006","journal-title":"J. Gen. Virol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/jmv.20173","article-title":"Secretory IgA Antibodies Provide Cross-ProtectionAgainst Infection with Different Strainsof Influenza B Virus","volume":"74","author":"Yoshikawa","year":"2004","journal-title":"J. Med. Virol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e2107148118","DOI":"10.1073\/pnas.2107148118","article-title":"Increased in vitro neutralizing activity of SARS-CoV-2 IgA1 dimers compared to monomers and IgG","volume":"118","author":"Sun","year":"2021","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"eabd2223","DOI":"10.1126\/scitranslmed.abd2223","article-title":"IgA dominates the early neutralizing antibody response to SARS-CoV-2","volume":"13","author":"Sterlin","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e03192-20","DOI":"10.1128\/mBio.03192-20","article-title":"Characterization of SARS-CoV-2 RNA, Antibodies, and Neutralizing Capacity in Milk Produced by Women with COVID-19","volume":"12","author":"Pace","year":"2021","journal-title":"mBio"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.jaci.2019.11.051","article-title":"Characterization of the clinical and immunologic phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations","volume":"146","author":"Lorenzini","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"E527","DOI":"10.1016\/S2666-5247(21)00129-4","article-title":"Neutralisation of SARS-CoV-2 lineage P.1 by antibodies elicited through natural SARS-CoV-2 infection or vaccination with an inactivated SARS-CoV-2 vaccine: An immunological study","volume":"2","author":"Souza","year":"2021","journal-title":"Lancet Microbe"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.46234\/ccdcw2021.255","article-title":"GISAID\u2019s Role in Pandemic Response","volume":"3","author":"Khare","year":"2021","journal-title":"China CDC Wkly."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"104632","DOI":"10.1016\/j.jcv.2020.104632","article-title":"Comparison of the GeneFinder TM COVID-19 Plus RealAmp Kit on the sample-to-result Platform ELITeInGenius to the national reference method: An added value of N gene target detection?","volume":"132","author":"Ong","year":"2020","journal-title":"J. Clin. Virol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2000045","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000045","article-title":"Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR","volume":"25","author":"Corman","year":"2020","journal-title":"Euro Surveill."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1126\/science.abh2644","article-title":"Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil","volume":"372","author":"Faria","year":"2021","journal-title":"Science"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1126\/science.abd2161","article-title":"Evolution and epidemic spread of SARS-CoV-2 in Brazil","volume":"369","author":"Candido","year":"2020","journal-title":"Science"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1093\/bioinformatics\/btab540","article-title":"Accurate spliced alignment of long RNA sequencing reads","volume":"37","author":"Sahlin","year":"2021","journal-title":"Bioinformatics"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"veab064","DOI":"10.1093\/ve\/veab064","article-title":"Assignment of epidemiological lineages in an emerging pandemic using the pangolin tool","volume":"7","author":"Scher","year":"2021","journal-title":"Virus Evol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1093\/bioinformatics\/bty407","article-title":"Nextstrain: Real-time tracking of pathogen evolution","volume":"34","author":"Hadfield","year":"2018","journal-title":"Bioinformatics"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e239108","DOI":"10.1136\/bcr-2020-239108","article-title":"COVID-19 infection in the palatine tonsil tissue and detritus: The detection of the virus compartment withRT-PCR","volume":"14","author":"Kadriyan","year":"2021","journal-title":"BMJ Case Rep"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/s41385-021-00437-z","article-title":"Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+T cells","volume":"14","author":"Lehmann","year":"2021","journal-title":"Mucosal Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1080\/22221751.2020.1827985","article-title":"Robust and persistent SARS-CoV-2 infection in the human intestinal brush border expressing cells","volume":"9","author":"Lee","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Mishra, M., Zahra, A., Chauhan, L.V., Thakkar, R., Ng, J., Joshi, S., Spitzer, E.D., Marcos, L.A., Lipkin, W.I., and Mishra, N. (2022). A Short Series of Case Reports of COVID-19 in Immunocompromised Patients. Viruses, 14.","DOI":"10.3390\/v14050934"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11904-021-00590-x","article-title":"Impact of Chronic HIV Infection on SARS-CoV-2 Infection, COVID-19 Disease and Vaccines","volume":"19","author":"Yang","year":"2022","journal-title":"Curr. HIV\/AIDS Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1001\/jama.2021.5782","article-title":"SARS-CoV-2-Specific Antibodies in Breast Milk After COVID-19 Vaccination of Breastfeeding Women","volume":"325","author":"Perl","year":"2021","journal-title":"JAMA"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.cell.2021.02.031","article-title":"The multifaceted roles of breast milk antibodies","volume":"184","author":"Atyeo","year":"2021","journal-title":"Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/INF.0b013e318281e34f","article-title":"The Effect of Exclusive Breast-feeding on Respiratory Illness in Young Infants in a Maternal Immunization Trial in Bangladesh","volume":"32","author":"Henkle","year":"2013","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1038\/s41467-019-11152-6","article-title":"Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response","volume":"10","author":"Antunes","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41584-021-00608-z","article-title":"Systemic and organ-specific immune-related manifestations of COVID-19","volume":"17","author":"Mariette","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1001\/jama.2021.15125","article-title":"Comparison of SARS-CoV-2 Antibody Response Following Vaccination with BNT162b2 and mRNA-1273","volume":"326","author":"Steensels","year":"2021","journal-title":"JAMA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e274","DOI":"10.1016\/S2666-5247(21)00305-0","article-title":"Comparison of SARS-CoV-2 anti-spike receptor binding domain IgG antibody responses after CoronaVac, BNT162b2, ChAdOx1 COVID-19 vaccines, and a single booster dose: A prospective, longitudinal population-based study","volume":"4","author":"Barin","year":"2022","journal-title":"Lancet Microbe"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1001\/jama.2021.19996","article-title":"Durability of Antibody Levels After Vaccination With mRNA SARS-CoV-2 Vaccine in Individuals with or Without Prior Infection","volume":"326","author":"Zhong","year":"2021","journal-title":"JAMA"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41586-021-03738-2","article-title":"SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses","volume":"596","author":"Turner","year":"2021","journal-title":"Nature"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Trofin, F., Nastase, E.V., Iancu, L.S., Constantinescu, D., Cianga, C.M., and Lunca, C. (2022). Anti-RBD IgA and IgG Response and Transmission in Breast Milk of Anti-SARS-CoV-2 Vaccinated Mothers. Pathogens, 11.","DOI":"10.3390\/pathogens11030286"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.cell.2022.01.011","article-title":"SARS-CoV-2 breakthrough infections elicit potent, broad, and durable neutralizing antibody responses","volume":"185","author":"Walls","year":"2022","journal-title":"Cell"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1056\/NEJMc2201849","article-title":"Neutralization of the SARS-CoV-2 Omicron BA.1 and BA.2 Variants","volume":"386","author":"Yu","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1056\/NEJMc2031364","article-title":"Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host","volume":"383","author":"Choi","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1056\/NEJMsb2104756","article-title":"SARS-CoV-2 Variants in Patients with Immunosuppression","volume":"385","author":"Corey","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41586-021-03291-y","article-title":"SARS-CoV-2 evolution during treatment of chronic infection","volume":"592","author":"Kemp","year":"2021","journal-title":"Nature"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/5\/1042\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:10:38Z","timestamp":1760137838000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/5\/1042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,13]]},"references-count":38,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["v14051042"],"URL":"https:\/\/doi.org\/10.3390\/v14051042","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,13]]}}}