{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:29:07Z","timestamp":1760228947888,"version":"build-2065373602"},"reference-count":41,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T00:00:00Z","timestamp":1653696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\u2014CNPQ","award":["480128\/2013-8","312979\/2018-5","301869\/2017-0"],"award-info":[{"award-number":["480128\/2013-8","312979\/2018-5","301869\/2017-0"]}]},{"name":"the Federal University of Para","award":["480128\/2013-8","312979\/2018-5","301869\/2017-0"],"award-info":[{"award-number":["480128\/2013-8","312979\/2018-5","301869\/2017-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Genetic variations in components of the immune response seem to be an important factor that contributes to the manifestation of symptoms of some diseases related to HTLV-1 infection. Nerve growth factor (NGF) and the p75 neurotrophin receptor (p75NTR) are related to the maintenance of neurons and the activation of the immune response. In this study, we evaluated the association of the NGF -198C\/T, NGF Ala35Val, and p75NTR Ser205Leu polymorphisms with HTLV-1 infection and plasma cytokine levels in 166 samples from individuals infected with HTLV-1 (59 symptomatic and 107 asymptomatic). The genotyping and quantification of the proviral load were performed by real-time PCR, and cytokine levels were measured by ELISA. The NGF -198C\/T and NGF Ala35Val polymorphisms were not associated with HTLV-1 infection. The frequency of the Ser\/Leu genotype of p75NTR Ser205Leu was more frequent in the control group (p = 0.0385), and the Ser\/Leu genotype and allele Leu were more frequent among the asymptomatic (p &lt; 0.05), especially with respect to the HTLV-1-associated myelopathy (HAM) group (p &lt; 0.05). The symptomatic showed a higher proviral load and higher TNF-\u03b1 and IL-10 levels (p &lt; 0.05). Asymptomatic carriers of the Ser\/Leu genotype (p = 0.0797) had lower levels of proviral load and higher levels of TNF-\u03b1 (p = 0.0507). Based on the results obtained, we conclude that the p75NTR Ser205Leu polymorphism may be associated with reduced susceptibility to HTLV-1 infection, a lower risk of developing symptoms, including HAM, and better infection control.<\/jats:p>","DOI":"10.3390\/v14061175","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T05:25:42Z","timestamp":1653974742000},"page":"1175","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of the p75NTR Ser205Leu Polymorphism with Asymptomatic HTLV-1 Infection"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2014-2770","authenticated-orcid":false,"given":"Maria Alice Freitas","family":"Queiroz","sequence":"first","affiliation":[{"name":"Laboratory of Virology, Institute of Biological Sciences, Federal University of Par\u00e1 (UFPA), Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe Teixeira","family":"Lopes","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Institute of Biological Sciences, Federal University of Par\u00e1 (UFPA), Bel\u00e9m 66075-110, Brazil"},{"name":"Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Par\u00e1 (UFPA), Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9341-9350","authenticated-orcid":false,"given":"Bruno Jos\u00e9 Sarmento","family":"Botelho","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Institute of Biological Sciences, Federal University of Par\u00e1 (UFPA), Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Karoliny da Silva","family":"Torres","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Institute of Biological Sciences, Federal University of Par\u00e1 (UFPA), Bel\u00e9m 66075-110, Brazil"},{"name":"Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Par\u00e1 (UFPA), Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7079-4844","authenticated-orcid":false,"given":"Ednelza da Gra\u00e7a Silva","family":"Amoras","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Institute of Biological Sciences, Federal University of Par\u00e1 (UFPA), Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A. da","family":"Costa","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Biology, Tropical Medicine Center, Federal University of Par\u00e1 (UFPA), Bel\u00e9m 66055-240, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u00edsa Silva","family":"Sousa","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Biology, Tropical Medicine Center, Federal University of Par\u00e1 (UFPA), Bel\u00e9m 66055-240, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Ishak","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Institute of Biological Sciences, Federal University of Par\u00e1 (UFPA), Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1135-6507","authenticated-orcid":false,"given":"Antonio Carlos Ros\u00e1rio","family":"Vallinoto","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Institute of Biological Sciences, Federal University of Par\u00e1 (UFPA), Bel\u00e9m 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1073\/pnas.79.5.1653","article-title":"Natural antibodies to the structural core protein (p24) of the human T-cell leucemia (lymphoma) retrov\u00edrus found in sera of leucemia in Japan","volume":"79","author":"Kalyanaraman","year":"1982","journal-title":"Proc. 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