{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:40:46Z","timestamp":1788824446055,"version":"build-2803163510"},"reference-count":29,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T00:00:00Z","timestamp":1653696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["72122001"],"award-info":[{"award-number":["72122001"]}]},{"name":"National Natural Science Foundation of China","award":["71934002"],"award-info":[{"award-number":["71934002"]}]},{"name":"National Natural Science Foundation of China","award":["2020ZX10001002"],"award-info":[{"award-number":["2020ZX10001002"]}]},{"name":"National Natural Science Foundation of China","award":["2021ZD0114101"],"award-info":[{"award-number":["2021ZD0114101"]}]},{"name":"National Natural Science Foundation of China","award":["2021ZD0114104"],"award-info":[{"award-number":["2021ZD0114104"]}]},{"name":"National Natural Science Foundation of China","award":["2021ZD0114105"],"award-info":[{"award-number":["2021ZD0114105"]}]},{"name":"National Natural Science Foundation of China","award":["2021LY038"],"award-info":[{"award-number":["2021LY038"]}]},{"name":"National Science and Technology Key Projects on Prevention and Treatment of Major infectious disease of China","award":["72122001"],"award-info":[{"award-number":["72122001"]}]},{"name":"National Science and Technology Key Projects on Prevention and Treatment of Major infectious disease of China","award":["71934002"],"award-info":[{"award-number":["71934002"]}]},{"name":"National Science and Technology Key Projects on Prevention and Treatment of Major infectious disease of China","award":["2020ZX10001002"],"award-info":[{"award-number":["2020ZX10001002"]}]},{"name":"National Science and Technology Key Projects on Prevention and Treatment of Major infectious disease of China","award":["2021ZD0114101"],"award-info":[{"award-number":["2021ZD0114101"]}]},{"name":"National Science and Technology Key Projects on Prevention and Treatment of Major infectious disease of China","award":["2021ZD0114104"],"award-info":[{"award-number":["2021ZD0114104"]}]},{"name":"National Science and Technology Key Projects on Prevention and Treatment of Major infectious disease of China","award":["2021ZD0114105"],"award-info":[{"award-number":["2021ZD0114105"]}]},{"name":"National Science and Technology Key Projects on Prevention and Treatment of Major infectious disease of China","award":["2021LY038"],"award-info":[{"award-number":["2021LY038"]}]},{"name":"National Key Research and Development Project of China","award":["72122001"],"award-info":[{"award-number":["72122001"]}]},{"name":"National Key Research and Development Project of China","award":["71934002"],"award-info":[{"award-number":["71934002"]}]},{"name":"National Key Research and Development Project of China","award":["2020ZX10001002"],"award-info":[{"award-number":["2020ZX10001002"]}]},{"name":"National Key Research and Development Project of China","award":["2021ZD0114101"],"award-info":[{"award-number":["2021ZD0114101"]}]},{"name":"National Key Research and Development Project of China","award":["2021ZD0114104"],"award-info":[{"award-number":["2021ZD0114104"]}]},{"name":"National Key Research and Development Project of China","award":["2021ZD0114105"],"award-info":[{"award-number":["2021ZD0114105"]}]},{"name":"National Key Research and Development Project of China","award":["2021LY038"],"award-info":[{"award-number":["2021LY038"]}]},{"name":"National Statistical Science Research Project","award":["72122001"],"award-info":[{"award-number":["72122001"]}]},{"name":"National Statistical Science Research Project","award":["71934002"],"award-info":[{"award-number":["71934002"]}]},{"name":"National Statistical Science Research Project","award":["2020ZX10001002"],"award-info":[{"award-number":["2020ZX10001002"]}]},{"name":"National Statistical Science Research Project","award":["2021ZD0114101"],"award-info":[{"award-number":["2021ZD0114101"]}]},{"name":"National Statistical Science Research Project","award":["2021ZD0114104"],"award-info":[{"award-number":["2021ZD0114104"]}]},{"name":"National Statistical Science Research Project","award":["2021ZD0114105"],"award-info":[{"award-number":["2021ZD0114105"]}]},{"name":"National Statistical Science Research Project","award":["2021LY038"],"award-info":[{"award-number":["2021LY038"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Asia has a very high burden of acute hepatitis; thus, a comprehensive study of the current burden and long-term trends of acute hepatitis in Asia is needed. We aimed to assess the current status and trends from 1990 to 2019 of acute hepatitis burden in Asia, using the data from the Global Burden of Diseases Study 2019 (GBD 2019) results. Methods: We used the data from the GBD 2019. Absolute death, incidence, and disability adjusted life years (DALY) number and rate of acute hepatitis in Asia were derived from the database from 1990 to 2019. Age-standardized mortality, incidence and DALY rates (ASMR, ASIR and ASDR) were used to compare populations in different regions and times. The estimated annual percentage change (EAPC) in the rates quantified the trends of the acute hepatitis burden. Results: From 1990 to 2019, the ASMR and ASDR of acute hepatitis decreased significantly at different paces, with the largest decrease in acute hepatitis C and the smallest in acute hepatitis E. The ASIR of acute hepatitis decreased relatively slowly, by an average of 0.06% (95% CI, 0.05\u20130.08%) per year in acute hepatitis A, 0.91% (0.64\u20131.18%) per year in acute hepatitis C and 0.26% (0.24\u20130.28%) per year in acute hepatitis E; while the ASIR of acute hepatitis B decreased by an average of 1.95% (1.08\u20132.11) per year. From 1990 to 2019, the incidence rate of acute hepatitis A increased in most age groups (from the age of 5 to 70), with the 50\u201355 years group having the fastest increase by an average of 1.81% (95% CI, 1.67\u20131.95%) per year. In 2019, Afghanistan had the highest ASMR (10.44 per 100,000) and ASDR (357.85 per 100,000) of acute hepatitis, and the highest ASIR was in Mongolia (4703.14 per 100,000). Conclusions: In Asia, the burden of acute viral hepatitis was at a relatively high level, compared with the other four continents. International cooperation and multifaceted and multisectoral actions are needed for Asian countries to eliminate viral hepatitis and to contribute to the global elimination of viral hepatitis.<\/jats:p>","DOI":"10.3390\/v14061180","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T05:25:42Z","timestamp":1653974742000},"page":"1180","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Burden and Trends of Acute Viral Hepatitis in Asia from 1990 to 2019"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6958-2091","authenticated-orcid":false,"given":"Qiao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5059-3743","authenticated-orcid":false,"given":"Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1938-9365","authenticated-orcid":false,"given":"Jue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China"},{"name":"Institute for Global Health and Development, Peking University, Beijing 100871, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,28]]},"reference":[{"key":"ref_1","unstructured":"(2022, April 10). World Health Organization Fact-Sheet: Hepatitis. Available online: https:\/\/www.who.int\/health-topics\/hepatitis#tab=tab_1."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.jhep.2016.12.003","article-title":"EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure","volume":"66","author":"Wendon","year":"2017","journal-title":"J. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0140-6736(19)31894-X","article-title":"Acute liver failure","volume":"394","author":"Stravitz","year":"2019","journal-title":"Lancet"},{"key":"ref_4","unstructured":"World Health Organization (2022, April 10). Global Hepatitis Report, 2017. Available online: https:\/\/www.who.int\/publications-detail-redirect\/9789241565455."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"James","year":"2018","journal-title":"Lancet"},{"key":"ref_6","unstructured":"World Health Organization (2022, April 10). Global Health Sector Strategy on Viral Hepatitis 2016\u20132021. Available online: https:\/\/www.who.int\/publications-detail-redirect\/WHO-HIV-2016.06."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"The Lancet Gastroenterology Hepatology (2020). Eliminating viral hepatitis in the COVID-19 era: Weighing challenge and opportunity. Lancet Gastroenterol. Hepatol., 5, 789.","DOI":"10.1016\/S2468-1253(20)30237-5"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S2468-1253(18)30270-X","article-title":"Accelerating the elimination of viral hepatitis: A Lancet Gastroenterology & Hepatology Commission","volume":"4","author":"Cooke","year":"2019","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/liv.14686","article-title":"The global trends and regional differences in incidence of HEV infection from 1990 to 2017 and implications for HEV prevention","volume":"41","author":"Jing","year":"2021","journal-title":"Liver Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"564","DOI":"10.46234\/ccdcw2020.151","article-title":"Global Trends and Regional Differences in Hepatitis C Virus Infection Prevalence and Implications for Prevention\u2014Worldwide, 1990\u20132017","volume":"2","author":"Jing","year":"2020","journal-title":"China CDC Wkly."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1007\/s12072-021-10232-4","article-title":"The global trends and regional differences in incidence and mortality of hepatitis A from 1990 to 2019 and implications for its prevention","volume":"15","author":"Cao","year":"2021","journal-title":"Hepatol. Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"230","DOI":"10.2471\/BLT.18.219469","article-title":"Countdown to 2030: Eliminating hepatitis B disease, China","volume":"97","author":"Liu","year":"2019","journal-title":"Bull. World Health Organ."},{"key":"ref_13","unstructured":"Global Burden of Disease Collaborative Network (2021, May 27). Global Burden of Disease Study 2019 (GBD 2019) Results. Available online: http:\/\/ghdx.healthdata.org\/gbd-results-tool."},{"key":"ref_14","unstructured":"Institute for Health Metrics and Evaluation (2021, May 27). The Global Burden of Disease: A Critical Resource for Informed Policymaking. Available online: http:\/\/www.healthdata.org\/gbd\/about."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: A systematic analysis for the Global Burden of Disease Study 2019","volume":"396","author":"Vos","year":"2020","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.jhep.2021.04.035","article-title":"Global burden of acute viral hepatitis and its association with socioeconomic development status, 1990\u20132019","volume":"75","author":"Zeng","year":"2021","journal-title":"J. Hepatol."},{"key":"ref_17","unstructured":"World Health Organization (2022, April 10). Progress Report on HIV, Viral Hepatitis and Sexually Transmitted Infections, 2019. Available online: https:\/\/apps.who.int\/iris\/rest\/bitstreams\/1254432\/retrieve."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"11941","DOI":"10.3748\/wjg.v21.i42.11941","article-title":"Hepatitis B virus burden in developing countries","volume":"21","author":"Zampino","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"17086","DOI":"10.1038\/nrdp.2017.86","article-title":"Hepatitis E virus infection","volume":"3","author":"Kamar","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_20","unstructured":"World Health Organization (2022, April 10). World Health Organization Fact-Sheet: Hepatitis E Virus. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-e."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.3748\/wjg.v27.i16.1691","article-title":"From hepatitis A to E: A critical review of viral hepatitis","volume":"27","author":"Castaneda","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"ref_22","unstructured":"World Health Organization (2022, April 10). World Health Organization Fact-Sheet: Hepatitis A Virus. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-a."},{"key":"ref_23","unstructured":"World Health Organization (2022, April 10). Progress Report on Access to Hepatitis C Treatment. Available online: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/260445\/WHO-CDS-HIV-18.4-eng.pdf?sequence=1."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"773","DOI":"10.15585\/mmwr.mm6728a2","article-title":"Access to Treatment for Hepatitis B Virus Infection\u2014Worldwide, 2016","volume":"67","author":"Hutin","year":"2018","journal-title":"MMWR Morb. Mortal Wkly. Rep."},{"key":"ref_25","unstructured":"World Health Organization (2022, April 10). World Health Organization Fact-Sheet: Hepatitis B Virus. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-b."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1002\/hep.29196","article-title":"Overt acute hepatitis B is more severe in female patients","volume":"66","author":"Chang","year":"2017","journal-title":"Hepatology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11684-020-0744-2","article-title":"Eliminating mother-to-child transmission of HBV: Progress and challenges in China","volume":"14","author":"Jing","year":"2020","journal-title":"Front. Med."},{"key":"ref_28","unstructured":"World Health Organization (2022, April 10). WHO\/UNICEF Estimates. Available online: http:\/\/apps.who.int\/immunization_monitoring\/globalsummary\/timeseries\/tswucoveragedtp3.html."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/1756-3305-4-211","article-title":"Comparison of intestinal parasitic infection in newly arrived and resident workers in Qatar","volume":"4","author":"Behnke","year":"2011","journal-title":"Parasites Vectors"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/6\/1180\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:20:38Z","timestamp":1760138438000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/6\/1180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,28]]},"references-count":29,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["v14061180"],"URL":"https:\/\/doi.org\/10.3390\/v14061180","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,28]]}}}