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Most flaviviruses are transmitted by mosquitoes or ticks and are widely distributed all over the world. Among them, several mosquito-borne flaviviruses are co-epidemic, and the similarity of their antigenicity creates abundant cross-reactive immune responses which complicate their prevention and control. At present, only effective vaccines against yellow fever and Japanese encephalitis have been used clinically, while the optimal vaccines against other flavivirus diseases are still under development. The antibody-dependent enhancement generated by cross-reactive immune responses against different serotypes of dengue virus makes the development of the dengue fever vaccine a bottleneck. It has been proposed that the cross-reactive immunity elicited by prior infection of mosquito-borne flavivirus could also affect the outcome of the subsequent infection of heterologous flavivirus. In this review, we focused on five medically important flaviviruses, and rearranged and recapitulated their cross-reactive immunity in detail from the perspectives of serological experiments in vitro, animal experiments in vivo, and human cohort studies. We look forward to providing references and new insights for the research of flavivirus vaccines and specific prevention.<\/jats:p>","DOI":"10.3390\/v14061213","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T08:01:18Z","timestamp":1654243278000},"page":"1213","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Cross-Reactive Immunity among Five Medically Important Mosquito-Borne Flaviviruses Related to Human Diseases"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8250-7272","authenticated-orcid":false,"given":"Baohua","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China"},{"name":"Experimental Center for Basic Medical Teaching, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2567-0380","authenticated-orcid":false,"given":"Jing","family":"An","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China"},{"name":"Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing 100093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1056\/NEJMc1800098","article-title":"Neurodevelopment in Infants Exposed to Zika Virus In Utero","volume":"379","author":"Moreira","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"739970","DOI":"10.3389\/fmicb.2022.739970","article-title":"Clinical Characteristics and Risk Factors for Severe Dengue Fever in Xishuangbanna, During the Dengue Outbreak in 2019","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s41577-020-00410-0","article-title":"The role of IgG Fc receptors in antibody-dependent enhancement","volume":"20","author":"Bournazos","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Breitbach, M.E., Newman, C.M., Dudley, D.M., Stewart, L.M., Aliota, M.T., Koenig, M.R., Shepherd, P.M., Yamamoto, K., Crooks, C.M., and Young, G. (2019). Primary infection with dengue or Zika virus does not affect the severity of heterologous secondary infection in macaques. PLoS Pathog., 15.","DOI":"10.1371\/journal.ppat.1007766"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/infdis\/jiy482","article-title":"Dengue Virus and Zika Virus Serological Cross-reactivity and Their Impact on Pathogenesis in Mice","volume":"219","author":"Watanabe","year":"2019","journal-title":"J. Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.scib.2019.11.006","article-title":"The pre-existing cellular immunity to Japanese encephalitis virus heterotypically protects mice from Zika virus infection","volume":"65","author":"Zhang","year":"2020","journal-title":"Sci. Bull."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.clinthera.2017.07.001","article-title":"Progress and Works in Progress: Update on Flavivirus Vaccine Development","volume":"39","author":"Collins","year":"2017","journal-title":"Clin. Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/s41564-020-0714-0","article-title":"The continued threat of emerging flaviviruses","volume":"5","author":"Pierson","year":"2020","journal-title":"Nat. Microbiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0140-6736(14)60572-9","article-title":"Dengue","volume":"385","author":"Guzman","year":"2015","journal-title":"Lancet"},{"key":"ref_10","first-page":"1701","article-title":"Specific detection and differentiation of tick-borne encephalitis and West Nile virus induced IgG antibodies in humans and horses","volume":"66","author":"Rockstroh","year":"2019","journal-title":"Transbound. Emerg. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.virol.2015.03.020","article-title":"Limited susceptibility of mice to Usutu virus (USUV) infection and induction of flavivirus cross-protective immunity","volume":"482","author":"Blazquez","year":"2015","journal-title":"Virology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.bbrc.2017.05.050","article-title":"Interaction of Flavivirus with their mosquito vectors and their impact on the human health in the Americas","volume":"492","author":"Valderrama","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1080\/21645515.2017.1285472","article-title":"Japanese encephalitis vaccines: Immunogenicity, protective efficacy, effectiveness, and impact on the burden of disease","volume":"13","author":"Hegde","year":"2017","journal-title":"Hum. Vacc. Immunother."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13567-021-00966-2","article-title":"Structure and function of capsid protein in flavivirus infection and its applications in the development of vaccines and therapeutics","volume":"52","author":"Zhang","year":"2021","journal-title":"Vet. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.meegid.2018.11.023","article-title":"Antigenic relationship among zoonotic flaviviruses from Italy","volume":"68","author":"Lorusso","year":"2019","journal-title":"Infect. Genet. Evol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"517","DOI":"10.2471\/BLT.16.182105","article-title":"Systematic analysis of protein identity between Zika virus and other arthropod-borne viruses","volume":"95","author":"Chang","year":"2017","journal-title":"Bull. World Health Organ."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"198343","DOI":"10.1016\/j.virusres.2021.198343","article-title":"Structural and biochemical insights into flavivirus proteins","volume":"296","author":"Dey","year":"2021","journal-title":"Virus Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41594-017-0010-8","article-title":"Structural biology of Zika virus and other flaviviruses","volume":"25","author":"Hasan","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/iub.1556","article-title":"Molecular basis of antibody-mediated neutralization and protection against flavivirus","volume":"68","author":"Dai","year":"2016","journal-title":"IUBMB Life"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e1116","DOI":"10.1128\/mBio.01123-16","article-title":"Dengue Virus Envelope Dimer Epitope Monoclonal Antibodies Isolated from Dengue Patients Are Protective against Zika Virus","volume":"7","author":"Swanstrom","year":"2016","journal-title":"mBio"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/ni.3515","article-title":"Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus","volume":"17","author":"Dejnirattisai","year":"2016","journal-title":"Nat. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1126\/science.aal4365","article-title":"Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity","volume":"356","author":"Bardina","year":"2017","journal-title":"Science"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/infdis\/jiaa120","article-title":"Primary and Secondary Dengue Virus Infections Elicit Similar Memory B-Cell Responses, but Breadth to Other Serotypes and Cross-Reactivity to Zika Virus is Higher in Secondary Dengue","volume":"222","author":"Andrade","year":"2020","journal-title":"J. Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Serrano-Collazo, C., Perez-Guzman, E.X., Pantoja, P., Hassert, M.A., Rodriguez, I.V., Giavedoni, L., Hodara, V., Parodi, L., Cruz, L., and Arana, T. (2020). Effective control of early Zika virus replication by Dengue immunity is associated to the length of time between the 2 infections but not mediated by antibodies. PLoS Negl. Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0008285"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1038\/s41467-017-01669-z","article-title":"Dengue virus-reactive CD8(+) T cells mediate cross-protection against subsequent Zika virus challenge","volume":"8","author":"Wen","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"107566","DOI":"10.1016\/j.celrep.2020.107566","article-title":"CD4(+) T Cells Cross-Reactive with Dengue and Zika Viruses Protect against Zika Virus Infection","volume":"31","author":"Wen","year":"2020","journal-title":"Cell Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1038\/s41467-018-05458-0","article-title":"Cross-reactive Dengue virus-specific CD8+ T cells protect against Zika virus during pregnancy","volume":"9","author":"Ngono","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"15674","DOI":"10.1038\/ncomms15674","article-title":"Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus","volume":"8","author":"Pantoja","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Larocca, R.A., Abbink, P., Ventura, J.D., Chandrashekar, A., Mercado, N., Li, Z., Borducchi, E., de la Barrera, R.A., Eckels, K.H., and Modjarrad, K. (2021). Impact of prior Dengue immunity on Zika vaccine protection in rhesus macaques and mice. PLoS Pathog., 17.","DOI":"10.1371\/journal.ppat.1009673"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3389\/fimmu.2020.00185","article-title":"Strong CD4 T Cell Responses to Zika Virus Antigens in a Cohort of Dengue Virus Immune Mothers of Congenital Zika Virus Syndrome Infants","volume":"11","author":"Reynolds","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1038\/s41598-020-58407-7","article-title":"Association of past dengue fever epidemics with the risk of Zika microcephaly at the population level in Brazil","volume":"10","author":"Carvalho","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.3201\/eid2508.190113","article-title":"Cross-Protection of Dengue Virus Infection against Congenital Zika Syndrome, Northeastern Brazil","volume":"25","author":"Pedroso","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"9634","DOI":"10.1038\/s41598-021-88933-x","article-title":"Repeated exposure to dengue virus elicits robust cross neutralizing antibodies against Zika virus in residents of Northeastern Thailand","volume":"11","author":"Hattakam","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1093\/infdis\/jiw377","article-title":"Zika Virus\u2013Induced Antibody Response Enhances Dengue Virus Serotype 2 Replication In Vitro","volume":"214","author":"Kawiecki","year":"2016","journal-title":"J. Infect. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"g9478","DOI":"10.1126\/scitranslmed.abg9478","article-title":"Dengue and Zika virus infections in children elicit cross-reactive protective and enhancing antibodies that persist long term","volume":"13","author":"Katzelnick","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Langerak, T., Kasbergen, L., Chandler, F., Brinkman, T., Faerber, Z., Phalai, K., Ulbert, S., Rockstroh, A., Bruin, E., and Koopmans, M. (2021). Zika Virus Antibody Titers Three Years after Confirmed Infection. Viruses, 13.","DOI":"10.3390\/v13071345"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.aaf8505","article-title":"Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection","volume":"353","author":"Stettler","year":"2016","journal-title":"Science"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"r4297","DOI":"10.1126\/sciadv.aar4297","article-title":"Flavivirus serocomplex cross-reactive immunity is protective by activating heterologous memory CD4 T cells","volume":"4","author":"Saron","year":"2018","journal-title":"Sci. Adv."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.tmaid.2019.05.002","article-title":"Yellow fever (YF) vaccination does not increase dengue severity: A retrospective study based on 11,448 dengue notifications in a YF and dengue endemic region","volume":"30","author":"Luppe","year":"2019","journal-title":"Travel Med. Infect. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e00089-20","DOI":"10.1128\/JVI.00089-20","article-title":"T Cell Responses Induced by Attenuated Flavivirus Vaccination Are Specific and Show Limited Cross-Reactivity with Other Flavivirus Species","volume":"94","author":"Grifoni","year":"2020","journal-title":"J. Virol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4103\/0974-777X.56257","article-title":"Anamnestic immune response to dengue and decreased severity of yellow Fever","volume":"1","author":"Izurieta","year":"2009","journal-title":"J. Glob. Infect. Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00430-020-00658-2","article-title":"The effects of Japanese encephalitis virus antibodies on Zika virus infection","volume":"209","author":"He","year":"2020","journal-title":"Med. Microbiol. Immun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e20192152","DOI":"10.1084\/jem.20192152","article-title":"Japanese encephalitis virus-primed CD8+ T cells prevent antibody-dependent enhancement of Zika virus pathogenesis","volume":"217","author":"Chen","year":"2020","journal-title":"J. Exp. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"577546","DOI":"10.3389\/fimmu.2020.577546","article-title":"Japanese Encephalitis Virus Vaccination Elicits Cross-Reactive HLA-Class I-Restricted CD8 T Cell Response Against Zika Virus Infection","volume":"11","author":"Tarbe","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"6779","DOI":"10.1007\/s00253-020-10710-z","article-title":"T cell immunity rather than antibody mediates cross-protection against Zika virus infection conferred by a live attenuated Japanese encephalitis SA14-14-2 vaccine","volume":"104","author":"Wang","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"640190","DOI":"10.3389\/fimmu.2021.640190","article-title":"Pre-existing Immunity to Japanese Encephalitis Virus Alters CD4 T Cell Responses to Zika Virus Inactivated Vaccine","volume":"12","author":"Lima","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Saito, Y., Moi, M.L., Takeshita, N., Lim, C., Shiba, H., Hosono, K., Saijo, M., Kurane, I., and Takasaki, T. (2016). Japanese encephalitis vaccine-facilitated dengue virus infection-enhancement antibody in adults. BMC Infect. Dis., 16.","DOI":"10.1186\/s12879-016-1873-8"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"19953","DOI":"10.1038\/srep19953","article-title":"Cross-protection induced by Japanese encephalitis vaccines against different genotypes of Dengue viruses in mice","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Komiya, T., Honda-Okubo, Y., Baldwin, J., and Petrovsky, N. (2021). An Advax-Adjuvanted Inactivated Cell-Culture Derived Japanese Encephalitis Vaccine Induces Broadly Neutralising Anti-Flavivirus Antibodies, Robust Cellular Immunity and Provides Single Dose Protection. Vaccines, 9.","DOI":"10.20944\/preprints202110.0034.v1"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Anderson, K.B., Gibbons, R.V., Thomas, S.J., Rothman, A.L., Nisalak, A., Berkelman, R.L., Libraty, D.H., Endy, T.P., and Singh, S.K. (2011). Preexisting Japanese encephalitis virus neutralizing antibodies and increased symptomatic dengue illness in a school-based cohort in Thailand. PLoS Negl. Trop. Dis., 5.","DOI":"10.1371\/journal.pntd.0001311"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s10096-018-3207-9","article-title":"Effect of prior dengue infection on severity and outcome of Japanese encephalitis","volume":"37","author":"Verma","year":"2018","journal-title":"Eur. J. Clin. Microbiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4785","DOI":"10.1016\/j.vaccine.2005.04.036","article-title":"The suitability of yellow fever and Japanese encephalitis vaccines for immunization against West Nile virus","volume":"23","author":"Yamshchikov","year":"2005","journal-title":"Vaccine"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"999","DOI":"10.4269\/ajtmh.2008.78.999","article-title":"Short Report: Failure of Japanese Encephalitis Vaccine and Infection in Inducing Neutralizing Antibodies against West Nile Virus, People\u2019s Republic of China","volume":"78","author":"Tang","year":"2008","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.imlet.2011.04.003","article-title":"Cross protection against lethal West Nile virus challenge in mice immunized with recombinant E protein domain III of Japanese encephalitis virus","volume":"138","author":"Li","year":"2011","journal-title":"Immunol. Lett."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41541-020-00220-4","article-title":"A replication-defective Japanese encephalitis virus (JEV) vaccine candidate with NS1 deletion confers dual protection against JEV and West Nile virus in mice","volume":"5","author":"Li","year":"2020","journal-title":"npj Vaccines"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3201\/eid0803.010238","article-title":"Immunization with heterologous flaviviruses protective against fatal West Nile encephalitis","volume":"8","author":"Tesh","year":"2002","journal-title":"Emerg. Infect. Dis."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.virol.2007.12.021","article-title":"Vero cell-derived inactivated West Nile (WN) vaccine induces protective immunity against lethal WN virus infection in mice and shows a facilitated neutralizing antibody response in mice previously immunized with Japanese encephalitis vaccine","volume":"374","author":"Lim","year":"2008","journal-title":"Virology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4514","DOI":"10.1016\/S0264-410X(03)00507-3","article-title":"Partial protective effect of inactivated Japanese encephalitis vaccine on lethal West Nile virus infection in mice","volume":"21","author":"Takasaki","year":"2003","journal-title":"Vaccine"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"10324","DOI":"10.1128\/JVI.00480-13","article-title":"An Inactivated Cell Culture Japanese Encephalitis Vaccine (JE-ADVAX) Formulated with Delta Inulin Adjuvant Provides Robust Heterologous Protection against West Nile Encephalitis via Cross-Protective Memory B Cells and Neutralizing Antibody","volume":"87","author":"Petrovsky","year":"2013","journal-title":"J. Virol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Kaufusi, P.H., Tseng, A.C., Kelley, J.F., and Nerurkar, V.R. (2020). Selective Reactivity of Anti-Japanese Encephalitis Virus NS4B Antibody Towards Different Flaviviruses. Viruses, 12.","DOI":"10.3390\/v12020212"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.vaccine.2007.10.055","article-title":"Immunization with West Nile virus envelope domain III protects mice against lethal infection with homologous and heterologous virus","volume":"26","author":"Martina","year":"2008","journal-title":"Vaccine"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.vetmic.2013.05.026","article-title":"Antibodies generated by immunization with the NS1 protein of West Nile virus confer partial protection against lethal Japanese encephalitis virus challenge","volume":"166","author":"Sun","year":"2013","journal-title":"Vet. Microbiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00705-021-05298-2","article-title":"Mammalian animal models for dengue virus infection: A recent overview","volume":"167","author":"Kayesh","year":"2022","journal-title":"Arch. Virol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Lai, S., Huang, Z., Zhou, H., Anders, K.L., Perkins, T.A., Yin, W., Li, Y., Mu, D., Chen, Q., and Zhang, Z. (2015). The changing epidemiology of dengue in China, 1990\u20132014: A descriptive analysis of 25 years of nationwide surveillance data. BMC Med., 13.","DOI":"10.1186\/s12916-015-0336-1"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ijid.2014.03.1392","article-title":"Severe dengue outbreak in Yunnan, China, 2013","volume":"27","author":"Zhang","year":"2014","journal-title":"Int. J. Infect. Dis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.1007\/s00253-019-09798-9","article-title":"Japanese encephalitis virus prM-E antigen immunization conferred protection against challenge by four different serotypes of Dengue viruses in mice","volume":"103","author":"Gao","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/s41590-021-00966-6","article-title":"Protective Zika vaccines engineered to eliminate enhancement of dengue infection via immunodominance switch","volume":"22","author":"Dai","year":"2021","journal-title":"Nat. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"102991","DOI":"10.1016\/j.ebiom.2020.102991","article-title":"Dengue and Zika virus infections are enhanced by live attenuated dengue vaccine but not by recombinant DSV4 vaccine candidate in mouse models","volume":"60","author":"Shukla","year":"2020","journal-title":"eBioMedicine"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/6\/1213\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:23:54Z","timestamp":1760138634000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/6\/1213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,2]]},"references-count":68,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["v14061213"],"URL":"https:\/\/doi.org\/10.3390\/v14061213","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,2]]}}}