{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:46:04Z","timestamp":1791582364806,"version":"4.3.4"},"reference-count":91,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018065","name":"EveryCat Health Foundation","doi-asserted-by":"publisher","award":["W21-007"],"award-info":[{"award-number":["W21-007"]}],"id":[{"id":"10.13039\/100018065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018065","name":"EveryCat Health Foundation","doi-asserted-by":"publisher","award":["2020-89-FM"],"award-info":[{"award-number":["2020-89-FM"]}],"id":[{"id":"10.13039\/100018065","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of California Davis Peter C. Kennedy Endowed Fellowship","award":["W21-007"],"award-info":[{"award-number":["W21-007"]}]},{"name":"University of California Davis Peter C. Kennedy Endowed Fellowship","award":["2020-89-FM"],"award-info":[{"award-number":["2020-89-FM"]}]},{"name":"University of California Center for Companion Animal Health, School of Veterinary Medicine, University of California, Davis","award":["W21-007"],"award-info":[{"award-number":["W21-007"]}]},{"name":"University of California Center for Companion Animal Health, School of Veterinary Medicine, University of California, Davis","award":["2020-89-FM"],"award-info":[{"award-number":["2020-89-FM"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Feline infectious peritonitis (FIP) is a disease of domestic cats caused by the genetic variant of the feline coronavirus (FCoV) and feline infectious peritonitis virus (FIPV), currently grouped into two serotypes, I and II. Although serotype I FIPV is more prevalent in cats with FIP, serotype II has been more extensively studied in vitro due to the relative ease in propagating this viral serotype in culture systems. As a result, more is known about serotype II FIPV than the more biologically prevalent serotype I. The primary cell receptor for serotype II has been determined, while it remains unknown for serotype I. The recent development of a culture-adapted feline cell line that more effectively propagates serotype I FIPV, FCWF-4 CU, derived from FCWF-4 cells available through the ATCC, offers the potential for an improved understanding of serotype I FIPV biology. To learn more about FIPV receptor biology, we determined targeted gene expression patterns in feline cells variably permissive to replication of serotype I or II FIPV. We utilized normal feline tissues to determine the immunohistochemical expression patterns of two known coronavirus receptors, ACE2 and DC-SIGN. Lastly, we compared the global transcriptomes of the two closely related FCWF-4 cell lines and identified viral transcripts with potential importance for the differential replication kinetics of serotype I FIPV.<\/jats:p>","DOI":"10.3390\/v14071356","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T01:59:47Z","timestamp":1655949587000},"page":"1356","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Serotype I and II Feline Coronavirus Replication and Gene Expression Patterns of Feline Cells\u2014Building a Better Understanding of Serotype I FIPV Biology"],"prefix":"10.3390","volume":"14","author":[{"given":"Sarah","family":"Cook","sequence":"first","affiliation":[{"name":"Graduate Group Integrative Pathobiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Castillo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonyia","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0341-210X","authenticated-orcid":false,"given":"Christine","family":"Haake","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0057-0604","authenticated-orcid":false,"given":"Brian","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3390\/v1020166","article-title":"Significance of coronavirus mutants in feces and diseased tissues of cats suffering from feline infectious peritonitis","volume":"1","author":"Pedersen","year":"2009","journal-title":"Viruses"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1006\/viro.1998.9045","article-title":"Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses","volume":"243","author":"Vennema","year":"1998","journal-title":"Virology"},{"key":"ref_3","first-page":"255","article-title":"Feline infectious peritonitis","volume":"3","author":"Wolfe","year":"1966","journal-title":"Vet. 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