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Like other members of alphaherpesviruses, PRV establishes a lifelong latent infection and occasionally reactivates from latency after stress stimulus in infected pigs. Latent infected pigs can then serve as the source of recurrent infection, which is one of the difficulties for PRV eradication. Virus latency refers to the retention of viral complete genomes without production of infectious progeny virus; however, following stress stimulus, the virus can be reactivated into lytic infection, which is known as the latency-reactivation cycle. Recently, several research have indicated that alphaherpesvirus latency and reactivation is regulated by a complex interplay between virus, neurons, and the immune system. However, with those limited reports, the relevant advances in PRV latency are lagging behind. Therefore, in this review we focus on the regulatory mechanisms in PRV latency via summarizing the progress of PRV itself and that of other alphaherpesviruses, which will improve our understanding in the underlying mechanism of PRV latency and help design novel therapeutic strategies to control PRV latency.<\/jats:p>","DOI":"10.3390\/v14071386","type":"journal-article","created":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T22:50:23Z","timestamp":1656283823000},"page":"1386","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A Comparison of Pseudorabies Virus Latency to Other \u03b1-Herpesvirinae Subfamily Members"],"prefix":"10.3390","volume":"14","author":[{"given":"Jing","family":"Chen","sequence":"first","affiliation":[{"name":"Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[{"name":"Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Wan","sequence":"additional","affiliation":[{"name":"Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixuan","family":"Li","sequence":"additional","affiliation":[{"name":"Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianci","family":"Peng","sequence":"additional","affiliation":[{"name":"Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rendong","family":"Fang","sequence":"additional","affiliation":[{"name":"Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China"},{"name":"Immunology Research Center, Medical Research Institute, Southwest University, Chongqing 402460, China"},{"name":"Chongqing Key Laboratory of Herbivore Science, Chongqing 400715, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyi","family":"Peng","sequence":"additional","affiliation":[{"name":"Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Ye","sequence":"additional","affiliation":[{"name":"Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1128\/MMBR.69.3.462-500.2005","article-title":"Molecular biology of pseudorabies virus: Impact on neurovirology and veterinary medicine","volume":"69","author":"Pomeranz","year":"2005","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e3690","DOI":"10.1093\/cid\/ciaa987","article-title":"A novel human acute encephalitis caused by pseudorabies virus variant strain","volume":"73","author":"Liu","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.3201\/eid1911.130177","article-title":"Pseudorabies virus variant in Bartha-K61\u2013vaccinated pigs, China, 2012","volume":"19","author":"An","year":"2013","journal-title":"Emerg. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3201\/eid2001.130531","article-title":"Pathogenic pseudorabies virus, China, 2012","volume":"20","author":"Yu","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.vetmic.2015.12.008","article-title":"Control of swine pseudorabies in China: Opportunities and limitations","volume":"183","author":"Sun","year":"2016","journal-title":"Vet. Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1128\/jvi.63.7.2908-2913.1989","article-title":"Detection of pseudorabies virus transcripts in trigeminal ganglia of latently infected swine","volume":"63","author":"Cheung","year":"1989","journal-title":"J. Virol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"6333","DOI":"10.1128\/JVI.74.14.6333-6338.2000","article-title":"Identification of the pseudorabies virus promoter required for latency-associated transcript gene expression in the natural host","volume":"74","author":"Jin","year":"2000","journal-title":"J. Virol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1093\/nar\/17.12.4637","article-title":"DNA nucleotide sequence analysis of the immediate-early gene of pseudorabies virus","volume":"17","author":"Cheung","year":"1989","journal-title":"Nucleic. Acids Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5260","DOI":"10.1128\/jvi.65.10.5260-5271.1991","article-title":"Cloning of the latency gene and the early protein 0 gene of pseudorabies virus","volume":"65","author":"Cheung","year":"1991","journal-title":"J. Virol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0378-1135(96)01305-3","article-title":"Recent developments in latency and recombination of Aujeszky\u2019s disease (pseudorabies) virus","volume":"55","author":"Maes","year":"1997","journal-title":"Vet. Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/0042-6822(91)90628-O","article-title":"The 5\u2032 and 3\u2032 limits of transcription in the pseudorabies virus latency associated transcription unit","volume":"182","author":"Priola","year":"1991","journal-title":"Virology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1128\/JVI.02181-14","article-title":"A 2.5-kilobase deletion containing a cluster of nine microRNAs in the latency-associated-transcript locus of the pseudorabies virus affects the host response of porcine trigeminal ganglia during established latency","volume":"89","author":"Mahjoub","year":"2015","journal-title":"J. Virol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Anselmo, A., Flori, L., Jaffrezic, F., Rutigliano, T., Cecere, M., Cortes-Perez, N., Lef\u00e8vre, F., Rogel-Gaillard, C., and Giuffra, E. (2011). Co-expression of host and viral microRNAs in porcine dendritic cells infected by the pseudorabies virus. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0017374"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Wu, Y.Q., Chen, D.J., He, H.B., Chen, D.S., Chen, L.L., Chen, H.C., and Liu, Z.F. (2012). Pseudorabies virus infected porcine epithelial cell line generates a diverse set of host microRNAs and a special cluster of viral microRNAs. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0030988"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"9781","DOI":"10.1128\/JVI.73.12.9781-9788.1999","article-title":"Expression of the pseudorabies virus latency associated transcript gene during productive infection of cultured cells","volume":"73","author":"Jin","year":"1999","journal-title":"J. Virol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"8045","DOI":"10.1128\/jvi.68.12.8045-8055.1994","article-title":"The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency","volume":"68","author":"Perng","year":"1994","journal-title":"J. Virol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1128\/jvi.70.1.282-291.1996","article-title":"The region of the herpes simplex virus type 1 LAT gene that is colinear with the ICP34.5 gene is not involved in spontaneous reactivation","volume":"70","author":"Perng","year":"1996","journal-title":"J. Virol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1128\/jvi.63.7.2893-2900.1989","article-title":"A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency","volume":"63","author":"Leib","year":"1989","journal-title":"J. Virol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/s41467-018-03569-2","article-title":"A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61","volume":"9","author":"Depledge","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1099\/vir.0.000128","article-title":"A comparison of herpes simplex virus type 1 and varicella-zoster virus latency and reactivation","volume":"96","author":"Kennedy","year":"2015","journal-title":"J. Gen. Virol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nature07103","article-title":"MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs","volume":"454","author":"Umbach","year":"2008","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.virol.2011.06.027","article-title":"Herpes simplex virus 1 microRNAs expressed abundantly during latent infection are not essential for latency in mouse trigeminal ganglia","volume":"417","author":"Kramer","year":"2011","journal-title":"Virology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s13365-015-0319-1","article-title":"A herpes simplex virus type 1 mutant disrupted for microRNA H2 with increased neurovirulence and rate of reactivation","volume":"21","author":"Jiang","year":"2015","journal-title":"J. Neurovirol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s40139-015-0085-z","article-title":"Emerging roles of herpesvirus microRNAs during in vivo infection and pathogenesis","volume":"3","author":"Feldman","year":"2015","journal-title":"Curr. Pathobiol. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/13550280701793957","article-title":"Identification of two small RNAs within the first 1.5-kb of the herpes simplex virus type 1-encoded latency-associated transcript","volume":"14","author":"Peng","year":"2008","journal-title":"J. Neurovirol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e0198521","DOI":"10.1128\/jvi.01985-21","article-title":"Herpes simplex virus 1 small noncoding RNAs 1 and 2 activate the herpesvirus entry mediator promoter","volume":"96","author":"Tormanen","year":"2022","journal-title":"J. Virol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"9131","DOI":"10.1128\/JVI.00871-09","article-title":"Two small RNAs encoded within the first 1.5 kilobases of the herpes simplex virus type 1 latency-associated transcript can inhibit productive infection and cooperate to inhibit apoptosis","volume":"83","author":"Shen","year":"2009","journal-title":"J. Virol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.virusres.2013.04.005","article-title":"Small non-coding RNAs encoded within the herpes simplex virus type 1 latency associated transcript (LAT) cooperate with the retinoic acid inducible gene I (RIG-I) to induce beta-interferon promoter activity and promote cell survival","volume":"175","author":"Jones","year":"2013","journal-title":"Virus Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e0005422","DOI":"10.1128\/jvi.00054-22","article-title":"Small noncoding RNA (sncRNA1) within the latency-associated transcript modulates herpes simplex virus 1 virulence and the host immune response during acute but not latent infection","volume":"96","author":"Tormanen","year":"2022","journal-title":"J. Virol."},{"key":"ref_30","first-page":"599","article-title":"HSV-1 thymidine kinase promotes virulence and latency in the mouse","volume":"24","author":"Gordon","year":"1983","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0042-6822(88)90417-5","article-title":"Virulence of and establishment of latency by genetically engineered deletion mutants of herpes simplex virus 1","volume":"162","author":"Meignier","year":"1988","journal-title":"Virology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4736","DOI":"10.1073\/pnas.86.12.4736","article-title":"Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate","volume":"86","author":"Coen","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/jmv.1890430319","article-title":"A thymidine kinase deficient HSV-2 strain causes acute keratitis and establishes trigeminal ganglionic latency, but poorly reactivates in vivo","volume":"43","author":"Stroop","year":"1994","journal-title":"J. Med. Virol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF01348987","article-title":"Experimental reactivation of bovine herpesvirus 1 (BHV-1) by means of corticosteroids in an intranasal rabbit model","volume":"112","author":"Brown","year":"1990","journal-title":"Arch. Virol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF01321129","article-title":"Latency and reactivation of a thymidine kinase-negative bovine herpesvirus 1 deletion mutant","volume":"122","author":"Whetstone","year":"1992","journal-title":"Arch. Virol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1053\/jcpa.2000.0406","article-title":"A comparative study of pseudorabies virus (PRV) strains with defects in thymidine kinase and glycoprotein genes","volume":"123","author":"Ferrari","year":"2000","journal-title":"J. Comp. Pathol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/BF01317195","article-title":"Latency of a thymidine kinase-negative pseudorabies vaccine-virus detected by the polymerase chain reaction","volume":"122","author":"Volz","year":"1992","journal-title":"Arch. Virol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/BF01309470","article-title":"Glycoprotein E of pseudorabies virus and homologous proteins in other alphaherpesvirinae","volume":"137","author":"Jacobs","year":"1994","journal-title":"Arch. Virol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1128\/JVI.73.5.4350-4359.1999","article-title":"Retrograde, transneuronal spread of pseudorabies virus in defined neuronal circuitry of the rat brain is facilitated by gE mutations that reduce virulence","volume":"73","author":"Yang","year":"1999","journal-title":"J. Virol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.virol.2021.02.011","article-title":"Anterograde transport of \u03b1-herpesviruses in neuronal axons","volume":"559","author":"DuRaine","year":"2021","journal-title":"Virology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1177\/104063879600800119","article-title":"Latency characteristics of an EPO and LLT mutant of pseudorabies virus","volume":"8","author":"Cheung","year":"1996","journal-title":"J. Vet. Diagn. Investig."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/S1286-4579(00)01285-5","article-title":"Replication and virulence of early protein 0 and long latency transcript deficient mutants of the Aujeszky\u2019s disease (pseudorabies) virus","volume":"2","author":"Braun","year":"2000","journal-title":"Microbes Infect."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s13365-020-00866-9","article-title":"Typical gene expression profile of pseudorabies virus reactivation from latency in swine trigeminal ganglion","volume":"26","author":"Wang","year":"2020","journal-title":"J. Neurovirol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1023\/A:1020959521745","article-title":"Suppression of promoter activity of the LAT gene by IE180 of pseudorabies virus","volume":"25","author":"Ou","year":"2002","journal-title":"Virus Genes"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.virol.2014.06.038","article-title":"Analysis of a bovine herpesvirus 1 protein encoded by an alternatively spliced latency related (LR) RNA that is abundantly expressed in latently infected neurons","volume":"464","author":"Sinani","year":"2014","journal-title":"Virology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5730","DOI":"10.1128\/jvi.64.12.5730-5737.1990","article-title":"Characterization of the latency-related transcriptionally active region of the bovine herpesvirus 1 genome","volume":"64","author":"Kutish","year":"1990","journal-title":"J. Virol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1080\/13550280701620754","article-title":"Identification of a novel protein encoded by the latency-related gene of bovine herpesvirus 1","volume":"13","author":"Meyer","year":"2007","journal-title":"J. Neurovirol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1128\/JVI.78.6.3184-3189.2004","article-title":"A mutation in the latency-related gene of bovine herpesvirus 1 inhibits protein expression of a protein from open reading frame 2 and an adjacent reading frame during productive infection","volume":"78","author":"Jiang","year":"2004","journal-title":"J. Virol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"6771","DOI":"10.1128\/JVI.76.13.6771-6779.2002","article-title":"A mutation in the latency related gene of bovine herpesvirus 1 interferes with the latency-reactivation cycle of latency in calves","volume":"76","author":"Inman","year":"2002","journal-title":"J. Virol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4848","DOI":"10.1128\/JVI.77.8.4848-4857.2003","article-title":"Infection of cattle with a bovine herpesvirus 1 (BHV-1) strain that contains a mutation in the latency related gene leads to increased apoptosis in trigeminal ganglia during the transition from acute infection to latency","volume":"77","author":"Lovato","year":"2003","journal-title":"J. Virol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"10940","DOI":"10.1128\/JVI.01289-08","article-title":"Open reading frame 2, encoded by the latency-related gene of bovine herpesvirus 1, has antiapoptotic activity in transiently transfected neuroblastoma cells","volume":"82","author":"Shen","year":"2008","journal-title":"J. Virol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.semcdb.2005.06.009","article-title":"Notch in the pathway: The roles of Notch signaling in neural crest development","volume":"16","author":"Cornell","year":"2005","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1128\/JVI.01937-10","article-title":"A protein (ORF2) encoded by the latency related gene of bovine herpesvirus 1 interacts with Notch1 and Notch3","volume":"85","author":"Workman","year":"2011","journal-title":"J. Virol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s13365-015-0394-3","article-title":"Regulation of Notch-mediated transcription by a bovine herpesvirus 1 encoded protein (ORF2) that is expressed in latently infected sensory neurons","volume":"22","author":"Liu","year":"2016","journal-title":"J. Neurovirol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"12124","DOI":"10.1128\/JVI.05478-11","article-title":"Localization of sequences in a protein (ORF2) encoded by the latency-related gene of bovine herpesvirus 1 that inhibits apoptosis and interferes with Notch1-mediated trans-activation of the bICP0 promoter","volume":"85","author":"Sinani","year":"2011","journal-title":"J. Virol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1089\/vim.2005.18.466","article-title":"Immune control of HSV-1 latency","volume":"18","author":"Decman","year":"2005","journal-title":"Viral. Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.coi.2004.05.003","article-title":"Immune control of herpes simplex virus during latency","volume":"16","author":"Khanna","year":"2004","journal-title":"Curr. Opin. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1099\/0022-1317-72-7-1601","article-title":"Endogenously produced interferon alpha protects mice from herpes simplex virus type 1 corneal disease","volume":"72","author":"Hendricks","year":"1991","journal-title":"J. Gen. Virol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"11821","DOI":"10.1128\/JVI.75.23.11821-11826.2001","article-title":"Alpha and gamma interferons inhibit herpes simplex virus type 1 infection and spread in epidermal cells after axonal transmission","volume":"75","author":"Mikloska","year":"2001","journal-title":"J. Virol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"11541","DOI":"10.1128\/JVI.76.22.11541-11550.2002","article-title":"Alpha\/Beta interferon and gamma interferon synergize to inhibit the replication of herpes simplex virus type 1","volume":"76","author":"Sainz","year":"2002","journal-title":"J. Virol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"De Regge, N., Van Opdenbosch, N., Nauwynck, H.J., Efstathiou, S., and Favoreel, H.W. (2010). Interferon alpha induces establishment of alphaherpesvirus latency in sensory neurons in vitro. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013076"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Maroui, M.A., Call\u00e9, A., Cohen, C., Streichenberger, N., Texier, P., Takissian, J., Rousseau, A., Poccardi, N., Welsch, J., and Corpet, A. (2016). Latency entry of herpes simplex virus 1 is determined by the interaction of its genome with the nuclear environment. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1005834"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e00103-19","DOI":"10.1128\/JVI.00103-19","article-title":"The latency-associated transcript inhibits apoptosis via downregulation of components of the type I interferon pathway during latent herpes simplex virus 1 ocular infection","volume":"93","author":"Tormanen","year":"2019","journal-title":"J. Virol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"801257","DOI":"10.3389\/fmicb.2021.801257","article-title":"Evasion of I interferon-mediated innate immunity by pseudorabies virus","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"108860","DOI":"10.1016\/j.vetmic.2020.108860","article-title":"PRV-encoded UL13 protein kinase acts as an antagonist of innate immunity by targeting IRF3-signaling pathways","volume":"250","author":"Lv","year":"2020","journal-title":"Vet. Microbiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"613","DOI":"10.4049\/jimmunol.2001306","article-title":"Pseudorabies virus DNA polymerase processivity factor UL42 inhibits type I IFN response by preventing ISGF3-ISRE interaction","volume":"207","author":"Zhang","year":"2021","journal-title":"J. Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e01148-17","DOI":"10.1128\/JVI.01148-17","article-title":"Pseudorabies virus dUTPase UL50 induces lysosomal degradation of type I interferon receptor 1 and antagonizes the alpha interferon response","volume":"91","author":"Zhang","year":"2017","journal-title":"J. Virol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"198276","DOI":"10.1016\/j.virusres.2020.198276","article-title":"Pseudorabies virus UL24 antagonizes OASL-mediated antiviral effect","volume":"295","author":"Chen","year":"2021","journal-title":"Virus Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.chom.2010.09.007","article-title":"Nature and duration of growth factor signaling through receptor tyrosine kinases regulates HSV-1 latency in neurons","volume":"8","author":"Camarena","year":"2010","journal-title":"Cell Host Microbe"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Koyuncu, O.O., MacGibeny, M.A., Hogue, I.B., and Enquist, L.W. (2017). Compartmented neuronal cultures reveal two distinct mechanisms for alpha herpesvirus escape from genome silencing. PLoS Pathog., 13.","DOI":"10.1371\/journal.ppat.1006608"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1084\/jem.185.11.1969","article-title":"T cell receptor-gamma\/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis","volume":"185","author":"Sciammas","year":"1997","journal-title":"J. Exp. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.4049\/jimmunol.162.5.2895","article-title":"Macrophage control of herpes simplex virus type 1 replication in the peripheral nervous system","volume":"162","author":"Kodukula","year":"1999","journal-title":"J. Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1126\/science.3317824","article-title":"The T cell receptor","volume":"238","author":"Marrack","year":"1987","journal-title":"Science"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1084\/jem.169.4.1503","article-title":"H-2-linked genes influence the severity of herpes simplex virus infection of the peripheral nervous system","volume":"169","author":"Simmons","year":"1989","journal-title":"J. Exp. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"144.11","DOI":"10.4049\/jimmunol.192.Supp.144.11","article-title":"Increased pathology in herpes stromal keratitis results from differences in local, and not systemic, immune responses (VIR5P. 1028)","volume":"192","author":"Sullivan","year":"2014","journal-title":"J. Immunol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1084\/jem.191.9.1459","article-title":"CD8+ T cells can block herpes simplex virus type 1 (HSV-1) reactivation from latency in sensory neurons","volume":"191","author":"Liu","year":"2000","journal-title":"J. Exp. Med."},{"key":"ref_77","first-page":"31","article-title":"The role of immune mechanisms in control of herpes simplex virus infection of the peripheral nervous system","volume":"179","author":"Simmons","year":"1992","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1099\/0022-1317-78-12-3317","article-title":"Cytokine production in the nervous system of mice during acute and latent infection with herpes simplex virus type 1","volume":"78","author":"Shimeld","year":"1997","journal-title":"J. Gen. Virol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"11178","DOI":"10.1128\/JVI.75.22.11178-11184.2001","article-title":"Gamma interferon can prevent herpes simplex virus type 1 reactivation from latency in sensory neurons","volume":"75","author":"Liu","year":"2001","journal-title":"J. Virol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1128\/JVI.73.4.3418-3423.1999","article-title":"Role for gamma interferon in control of herpes simplex virus type 1 reactivation","volume":"73","author":"Cantin","year":"1999","journal-title":"J. Virol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1128\/JVI.76.3.1077-1088.2002","article-title":"The cyclin-dependent kinase inhibitor roscovitine inhibits the transactivating activity and alters the posttranslational modification of herpes simplex virus type 1 ICP0","volume":"76","author":"Davido","year":"2002","journal-title":"J. Virol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/sj.onc.1201529","article-title":"Interferon induces expression of cyclin-dependent kinase-inhibitors p21WAF1 and p27Kip1 that prevent activation of cyclindependent kinase by CDK-activating kinase (CAK)","volume":"16","author":"Mandal","year":"1998","journal-title":"Oncogene"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e01193-19","DOI":"10.1128\/JVI.01193-19","article-title":"Herpes simplex virus 1-specific CD8+ T cell priming and latent ganglionic retention are shaped by viral epitope promoter kinetics","volume":"94","author":"Treat","year":"2020","journal-title":"J. Virol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1084\/jem.188.12.2205","article-title":"Viral immune evasion due to persistence of activated T cells without effector function","volume":"188","author":"Zajac","year":"1998","journal-title":"J. Exp. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/ni.2035","article-title":"T cell exhaustion","volume":"12","author":"Wherry","year":"2011","journal-title":"Nat. Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"8157","DOI":"10.1128\/JVI.00474-07","article-title":"Rates of reactivation of latent herpes simplex virus from mouse trigeminal ganglia ex vivo correlate directly with viral load and inversely with number of infiltrating CD8+ T cells","volume":"81","author":"Hoshino","year":"2007","journal-title":"J. Virol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.4049\/jimmunol.0902322","article-title":"A novel HLA (HLA-A*0201) transgenic rabbit model for preclinical evaluation of human CD8+ T cell epitopebased vaccines against ocular herpes","volume":"184","author":"Chentoufi","year":"2010","journal-title":"J. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"454","DOI":"10.4049\/jimmunol.2000131","article-title":"Upregulation of multiple CD8+ T cell exhaustion pathways is associated with recurrent ocular herpes simplex virus type 1 infection","volume":"205","author":"Coulon","year":"2020","journal-title":"J. Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4049\/jimmunol.0902373","article-title":"Early CD4+ T cell help prevents partial CD8+ T cell exhaustion and promotes maintenance of herpes simplex virus 1 latency","volume":"184","author":"Frank","year":"2010","journal-title":"J. Immunol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1016\/j.celrep.2018.10.105","article-title":"Critical role of regulatory T cells in the latency and stress-induced reactivation of HSV-1","volume":"25","author":"Yu","year":"2018","journal-title":"Cell Rep."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.2460\/ajvr.1992.53.11.2164","article-title":"Effect of various vaccination procedures on shedding, latency, and reactivation of attenuated and virulent pseudorabies virus in swine","volume":"53","author":"Mengeling","year":"1992","journal-title":"Am. J. Vet. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0378-1135(98)00200-4","article-title":"Vaccine genotype and route of administration affect pseudorabies field virus latency load after challenge","volume":"62","author":"Vilnis","year":"1998","journal-title":"Vet. Microbiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"8470","DOI":"10.1128\/jvi.68.12.8470-8476.1994","article-title":"Correlation between precolonization of trigeminal ganglia by attenuated strains of pseudorabies virus and resistance to wild-type virus latency","volume":"68","author":"Schang","year":"1994","journal-title":"J. Virol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/S0264-410X(98)00044-9","article-title":"A mouse model to study immunity against pseudorabies virus infection: Significance of CD4+ and CD8+ cells in protective immunity","volume":"16","author":"Bianchi","year":"1998","journal-title":"Vaccine"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.virol.2012.09.023","article-title":"Snapshots: Chromatin control of viral infection","volume":"435","author":"Knipe","year":"2013","journal-title":"Virology"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/302523a0","article-title":"Detection of HSV-1 genome in central nervous system of latently infected mice","volume":"302","author":"Rock","year":"1983","journal-title":"Nature"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1128\/jvi.63.2.943-947.1989","article-title":"During latency, herpes simplex virus type 1 DNA is associated with nucleosomes in a chromatin structure","volume":"63","author":"Deshmane","year":"1989","journal-title":"J. Virol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"16055","DOI":"10.1073\/pnas.0505850102","article-title":"Herpesviral latency-associated transcript gene promotes assembly of heterochromatin on viral lytic-gene promoters in latent infection","volume":"102","author":"Wang","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"8182","DOI":"10.1128\/JVI.00712-09","article-title":"Transcription of the herpes simplex virus latency-associated transcript promotes the formation of facultative heterochromatin on lytic promoters","volume":"83","author":"Cliffe","year":"2009","journal-title":"J. Virol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"8173","DOI":"10.1128\/JVI.00686-09","article-title":"The polycomb group protein Bmi1 binds to the herpes simplex virus 1 latent genome and maintains repressive histone marks during latency","volume":"83","author":"Kwiatkowski","year":"2009","journal-title":"J. Virol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1128\/jvi.34.2.521-531.1980","article-title":"Structural analysis of the capsid polypeptides of herpes simplex virus types 1 and 2","volume":"34","author":"Cohen","year":"1980","journal-title":"J. Virol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1128\/jvi.36.3.816-828.1980","article-title":"Analysis of herpes simplex virus nucleoprotein complexes extracted from infected cells","volume":"36","author":"Pignatti","year":"1980","journal-title":"J. Virol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1002\/j.1460-2075.1984.tb01959.x","article-title":"Assembly of transfected DNA into chromatin: Structural changes in the origin-promoter-enhancer region upon replication","volume":"3","author":"Cereghini","year":"1984","journal-title":"EMBO J."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35023615","article-title":"Annexation of the interchromosomal space during viral infection","volume":"2","author":"Monier","year":"2000","journal-title":"Nature Cell Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1128\/JVI.78.11.5591-5600.2004","article-title":"Herpes simplex virus 1 UL31 and UL34 gene products promote the late maturation of viral replication compartments to the nuclear periphery","volume":"78","author":"Baines","year":"2004","journal-title":"J. Virol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"9689","DOI":"10.1128\/JVI.78.18.9689-9696.2004","article-title":"VP16-dependent association of chromatin-modifying coactivators and underrepresentation of histones at immediate-early gene promoters during herpes simplex virus infection","volume":"78","author":"Herrera","year":"2004","journal-title":"J. Virol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nrmicro1794","article-title":"Chromatin control of herpes simplex virus lytic and latent infection","volume":"6","author":"Knipe","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"12030","DOI":"10.1128\/JVI.01575-08","article-title":"Herpes simplex virus ICP0 promotes both histone removal and acetylation on viral DNA during lytic infection","volume":"82","author":"Cliffe","year":"2008","journal-title":"J. Virol."},{"key":"ref_109","first-page":"585","article-title":"Chromatin state of some genome segment of pseudorabies virus during lytic infection","volume":"37","author":"Zhang","year":"2017","journal-title":"Chin. J. Vet. Sci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0092-8674(88)90044-X","article-title":"Transcriptional regulation by the immediate early protein of pseudorabies virus during in vitro nucleosome assembly","volume":"55","author":"Workman","year":"1988","journal-title":"Cell"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e00276-15","DOI":"10.1128\/mBio.00276-15","article-title":"The number of alphaherpesvirus particles infecting axons and the axonal protein repertoire determines the outcome of neuronal infection","volume":"6","author":"Koyuncu","year":"2015","journal-title":"MBio"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/7\/1386\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:39:55Z","timestamp":1760139595000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/7\/1386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,24]]},"references-count":111,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["v14071386"],"URL":"https:\/\/doi.org\/10.3390\/v14071386","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,24]]}}}