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CA252982"]}]},{"name":"National Institute of Allergy and Infectious Diseases","award":["P50 CA217694 SPORE"],"award-info":[{"award-number":["P50 CA217694 SPORE"]}]},{"name":"National Institute of Allergy and Infectious Diseases","award":["P50 CA192937"],"award-info":[{"award-number":["P50 CA192937"]}]},{"name":"National Institute of Allergy and Infectious Diseases","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}]},{"name":"National Institute of Allergy and Infectious Diseases","award":["R01GM057454"],"award-info":[{"award-number":["R01GM057454"]}]},{"name":"National Institute of Allergy and Infectious Diseases","award":["R01AI075647"],"award-info":[{"award-number":["R01AI075647"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Zika virus (ZIKV) and dengue virus (DENV) are members of the Flaviviridae family of RNA viruses and cause severe disease in humans. ZIKV and DENV share over 90% of their genome sequences, however, the clinical features of Zika and dengue infections are very different reflecting tropism and cellular effects. Here, we used simultaneous RNA sequencing and ribosome footprinting to define the transcriptional and translational dynamics of ZIKV and DENV infection in human neuronal progenitor cells (hNPCs). The gene expression data showed induction of aminoacyl tRNA synthetases (ARS) and the translation activating PIM1 kinase, indicating an increase in RNA translation capacity. The data also reveal activation of different cell stress responses, with ZIKV triggering a BACH1\/2 redox program, and DENV activating the ATF\/CHOP endoplasmic reticulum (ER) stress program. The RNA translation data highlight activation of polyamine metabolism through changes in key enzymes and their regulators. This pathway is needed for eIF5A hypusination and has been implicated in viral translation and replication. Concerning the viral RNA genomes, ribosome occupancy readily identified highly translated open reading frames and a novel upstream ORF (uORF) in the DENV genome. Together, our data highlight both the cellular stress response and the activation of RNA translation and polyamine metabolism during DENV and ZIKV infection.<\/jats:p>","DOI":"10.3390\/v14071418","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T03:26:37Z","timestamp":1656473197000},"page":"1418","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Transcriptional and Translational Dynamics of Zika and Dengue Virus Infection"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4608-222X","authenticated-orcid":false,"given":"Kamini","family":"Singh","sequence":"first","affiliation":[{"name":"Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA"},{"name":"Department of Molecular Pharmacology, Albert Einstein College of Medicine, Albert Einstein Cancer, Center, Bronx, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Guadalupe","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA"},{"name":"Global Innovation, Boehringer Ingelheim Animal Health, 69800 Saint-Priest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Lin","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032 and Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Gregory","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vagelos College of Physicians & Surgeons of Columbia University, New York, NY 10032, USA"},{"name":"Center for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY 10013, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trang Uyen","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology, Albert Einstein College of Medicine, Albert Einstein Cancer, Center, Bronx, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rawan","family":"Abdelaal","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1862-1046","authenticated-orcid":false,"given":"Kristy","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vagelos College of Physicians & Surgeons of Columbia University, New York, NY 10032, USA"},{"name":"Center for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY 10013, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Brennand","sequence":"additional","affiliation":[{"name":"Division of Molecular Psychiatry, Departments of Psychiatry and Genetics, Yale School of Medicine, New Haven, CT 06510, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Gr\u00fcnweller","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Chemistry, Philipps University Marburg, 35032 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengqing","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemali","family":"Phatnani","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vagelos College of Physicians & Surgeons of Columbia University, New York, NY 10032, USA"},{"name":"Center for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY 10013, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7395-4791","authenticated-orcid":false,"given":"Margaret","family":"Kielian","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Guido","family":"Wendel","sequence":"additional","affiliation":[{"name":"Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0140-6736(08)60238-X","article-title":"Pathogenic 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