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Microcefalia","award":["734584","201870\/Z\/16\/Z","205377\/Z\/16\/Z","107779\/Z\/15\/Z","ER1505","ER1601","MC_PC_15088","HHSN275201800001I","APQ-0192-4.01\/17","APQ-0172-4.01\/16","Finance Code 001","309722\/2017-9","306708\/2014-0","837058\/2016","440839\/2016-5"],"award-info":[{"award-number":["734584","201870\/Z\/16\/Z","205377\/Z\/16\/Z","107779\/Z\/15\/Z","ER1505","ER1601","MC_PC_15088","HHSN275201800001I","APQ-0192-4.01\/17","APQ-0172-4.01\/16","Finance Code 001","309722\/2017-9","306708\/2014-0","837058\/2016","440839\/2016-5"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico, Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","award":["734584","201870\/Z\/16\/Z","205377\/Z\/16\/Z","107779\/Z\/15\/Z","ER1505","ER1601","MC_PC_15088","HHSN275201800001I","APQ-0192-4.01\/17","APQ-0172-4.01\/16","Finance Code 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Methods: From October 2018 to March 2020, children with Zika-related microcephaly underwent urological, ultrasonographic and urodynamic evaluation. In selected cases, complementary exams such as urethrocystography and scintigraphy were performed. The children also underwent a complete neurological evaluation. To compare frequency between groups, we used Pearson\u2019s chi-squared test or Fisher\u2019s exact test. Results: This study evaluated 40 children, of whom 85% were 4 years old, and all had abnormalities on the urodynamic study, with low bladder capacity (92.5%) and detrusor overactivity (77.5%) as the most frequent findings. Only three children had ultrasound abnormalities, but no child had cystographic or scintigraphic abnormalities, and the postvoid residual volume was normal in 80% of cases. In spite of a frequency of 67.5% of intestinal constipation, there was no record of febrile urinary tract infection after the first year of life. All children presented severe microcephaly and at least one neurological abnormality in addition to microcephaly. The homogeneity of the children in relation to microcephaly severity and neurological abnormalities limited the study of the association with the urodynamic parameters. Conclusions: Urodynamic abnormalities in children aged 3 to 5 years with Zika-related microcephaly do not seem to characterize a neurogenic bladder with immediate risks for the upper urinary tract. The satisfactory bladder emptying suggests that the voiding pattern is reflex.<\/jats:p>","DOI":"10.3390\/v14071512","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T03:50:36Z","timestamp":1657597836000},"page":"1512","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Zika-Related Microcephaly and Its Repercussions for the Urinary Tract: Clinical, Urodynamic, Scintigraphic and Radiological Aspects"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1166-2099","authenticated-orcid":false,"given":"R\u00f4mulo Augusto Lucena","family":"de Vasconcelos","sequence":"first","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade de Pernambuco, Rua Arn\u00f3bio Marques, 310, Santo Amaro, Recife 50100-130, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Arraes de Alencar","family":"Ximenes","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade de Pernambuco, Rua Arn\u00f3bio Marques, 310, Santo Amaro, Recife 50100-130, Brazil"},{"name":"Departamento de Medicina Social, Universidade Federal de Pernambuco, Recife 50670-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano Almeida","family":"Calado","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade de Pernambuco, Rua Arn\u00f3bio Marques, 310, Santo Amaro, Recife 50100-130, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2491-0688","authenticated-orcid":false,"given":"Celina Maria Turchi","family":"Martelli","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Aggeu Magalh\u00e3es, Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Recife 50740-465, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreia","family":"Veras Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade de Pernambuco, Rua Arn\u00f3bio Marques, 310, Santo Amaro, Recife 50100-130, Brazil"},{"name":"Departamento de Medicina Social, Universidade Federal de Pernambuco, Recife 50670-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0280-2288","authenticated-orcid":false,"given":"Elizabeth Bailey","family":"Brickley","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thalia Velho Barreto de","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Social, Universidade Federal de Pernambuco, Recife 50670-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Angela","family":"Wanderley Rocha","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade de Pernambuco, Rua Arn\u00f3bio Marques, 310, Santo Amaro, Recife 50100-130, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dem\u00f3crito de Barros","family":"Miranda-Filho","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade de Pernambuco, Rua Arn\u00f3bio Marques, 310, Santo Amaro, Recife 50100-130, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,11]]},"reference":[{"key":"ref_1","unstructured":"Minist\u00e9rio da Sa\u00fade (2021, December 01). 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