{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T19:58:22Z","timestamp":1776455902479,"version":"3.51.2"},"reference-count":76,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31870146"],"award-info":[{"award-number":["31870146"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32100248"],"award-info":[{"award-number":["32100248"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2020J02014"],"award-info":[{"award-number":["2020J02014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fujian Province","award":["31870146"],"award-info":[{"award-number":["31870146"]}]},{"name":"Fujian Province","award":["32100248"],"award-info":[{"award-number":["32100248"]}]},{"name":"Fujian Province","award":["2020J02014"],"award-info":[{"award-number":["2020J02014"]}]},{"name":"Fujian Province Hundred-Talent","award":["31870146"],"award-info":[{"award-number":["31870146"]}]},{"name":"Fujian Province Hundred-Talent","award":["32100248"],"award-info":[{"award-number":["32100248"]}]},{"name":"Fujian Province Hundred-Talent","award":["2020J02014"],"award-info":[{"award-number":["2020J02014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Due to the impaired antiviral RNAi, the dcl2dcl4 (dcl2\/4) mutant is highly susceptible to viruses deficient of the viral suppressor of the RNA silencing (VSR) contrast to wild-type Arabidopsis. It was found that more severe disease symptoms were induced in dcl2\/4 infected with VSR-deficient CMV (CMV-\u03942b or CMV-2aT\u03942b) compared to wild-type Arabidopsis infected with intact CMV. In order to investigate the underlying mechanism, comparative transcriptome analysis was performed with Col-0 and dcl2\/4 that were infected by CMV, CMV-\u03942b and CMV-2aT\u03942b, respectively. Our analysis showed that the systematic infection of CMV, CMV-\u03942b and CMV-2aT\u03942b could cause hypoxia response and reduce photosynthesis. Asymptomatic infections of CMV-\u03942b or CMV-2aT\u03942b in Columbia (Col-0) promoted the expression of cell division-related genes and suppressed the transcription of metabolism and acquired resistance genes. On the other hand, immunity and resistance genes were highly induced, but photosynthesis and polysaccharide metabolism-related genes were suppressed in diseased plants. More interestingly, cell wall reorganization was specifically caused in modestly diseased Col-0 infected by CMV and a strong activation of SA signaling were correspondingly induced in severely diseased dcl2\/4 by CMV or CMV mutants. Thus, our research revealed the nature of the Arabidopsis\u2013CMV interaction at the transcriptome level and could provide new clues in symptom development and antiviral defense in plants.<\/jats:p>","DOI":"10.3390\/v14071582","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T03:58:44Z","timestamp":1658462324000},"page":"1582","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparative Transcriptome Analysis of CMV or 2b-Deficient CMV-Infected dcl2dcl4 Reveals the Effects of Viral Infection on Symptom Induction in Arabidopsis thaliana"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3598-3716","authenticated-orcid":false,"given":"Qian","family":"Xu","sequence":"first","affiliation":[{"name":"Vector-Borne Virus Research Center, State Key Laboratory for Ecological Pest Control of Fujian and Taiwan Crops, College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Shen","sequence":"additional","affiliation":[{"name":"Vector-Borne Virus Research Center, State Key Laboratory for Ecological Pest Control of Fujian and Taiwan Crops, College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liying","family":"Jin","sequence":"additional","affiliation":[{"name":"Vector-Borne Virus Research Center, State Key Laboratory for Ecological Pest Control of Fujian and Taiwan Crops, College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"Vector-Borne Virus Research Center, State Key Laboratory for Ecological Pest Control of Fujian and Taiwan Crops, College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenghan","family":"Chang","sequence":"additional","affiliation":[{"name":"Vector-Borne Virus Research Center, State Key Laboratory for Ecological Pest Control of Fujian and Taiwan Crops, College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7381-7765","authenticated-orcid":false,"given":"Zhongxin","family":"Guo","sequence":"additional","affiliation":[{"name":"Vector-Borne Virus Research Center, State Key Laboratory for Ecological Pest Control of Fujian and Taiwan Crops, College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41559-018-0793-y","article-title":"The global burden of pathogens and pests on major food crops","volume":"3","author":"Savary","year":"2019","journal-title":"Nat. Ecol. Evol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/j.1364-3703.2011.00752.x","article-title":"Top 10 plant viruses in molecular plant pathology","volume":"12","author":"Scholthof","year":"2011","journal-title":"Mol. Plant Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1098\/rstb.2010.0062","article-title":"Arabidopsis thaliana as a model for the study of plant-virus co-evolution","volume":"365","author":"Pagan","year":"2010","journal-title":"Philos. Trans. R. Soc. B"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1105\/tpc.109.072090","article-title":"The ubiquitin-proteasome system regulates the accumulation of Turnip yellow mosaic virus RNA-dependent RNA polymerase during viral infection","volume":"22","author":"Camborde","year":"2010","journal-title":"Plant Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1105\/tpc.106.047449","article-title":"Suppression of antiviral silencing by cucumber mosaic virus 2b protein in Arabidopsis is associated with drastically reduced accumulation of three classes of viral small interfering RNAs","volume":"19","author":"Li","year":"2007","journal-title":"Plant Cell"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.coviro.2012.09.004","article-title":"Towards an integrated molecular model of plant-virus interactions","volume":"2","author":"Elena","year":"2012","journal-title":"Curr. Opin. Virol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.chom.2014.08.001","article-title":"Nonsense-mediated decay serves as a general viral restriction mechanism in plants","volume":"16","author":"Garcia","year":"2014","journal-title":"Cell Host Microbe"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1111\/mpp.12851","article-title":"Host factors against plant viruses","volume":"20","year":"2019","journal-title":"Mol. Plant Pathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1105\/tpc.109.073056","article-title":"Arabidopsis RNA-dependent RNA polymerases and Dicer-like proteins in antiviral defense and small interfering RNA biogenesis during Turnip Mosaic Virus infection","volume":"22","author":"Takeda","year":"2010","journal-title":"Plant Cell"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1073\/pnas.1614204114","article-title":"Lipid flippases promote antiviral silencing and the biogenesis of viral and host siRNAs in Arabidopsis","volume":"114","author":"Guo","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0960-9822(02)00898-9","article-title":"Loss-of-susceptibility mutants of Arabidopsis thaliana reveal an essential role for eIF(iso)4E during potyvirus infection","volume":"12","author":"Lellis","year":"2002","journal-title":"Curr. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1038\/s41467-018-03658-2","article-title":"Beclin1 restricts RNA virus infection in plants through suppression and degradation of the viral polymerase","volume":"9","author":"Li","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"6102","DOI":"10.1128\/JVI.78.12.6102-6111.2004","article-title":"The Arabidopsis cucumovirus multiplication 1 and 2 loci encode translation initiation factors 4E and 4G","volume":"78","author":"Yoshii","year":"2004","journal-title":"J. Virol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/nri2824","article-title":"RNA-based antiviral immunity","volume":"10","author":"Ding","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41577-018-0071-x","article-title":"Small RNA-based antimicrobial immunity","volume":"19","author":"Guo","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.coviro.2018.08.003","article-title":"Dissection of RNAi-based antiviral immunity in plants","volume":"32","author":"Yang","year":"2018","journal-title":"Curr. Opin. Virol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.1093\/nar\/gkl886","article-title":"Four plant Dicers mediate viral small RNA biogenesis and DNA virus induced silencing","volume":"34","author":"Blevins","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1038\/sj.emboj.7601217","article-title":"An antagonistic function for Arabidopsis DCL2 in development and a new function for DCL4 in generating viral siRNAs","volume":"25","author":"Bouche","year":"2006","journal-title":"EMBO J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10265-016-0877-1","article-title":"Plant dicer-like proteins: Double-stranded RNA-cleaving enzymes for small RNA biogenesis","volume":"130","author":"Fukudome","year":"2017","journal-title":"J. Plant Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"14732","DOI":"10.1073\/pnas.0805760105","article-title":"Arabidopsis DRB4, AGO1, AGO7, and RDR6 participate in a DCL4-initiated antiviral RNA silencing pathway negatively regulated by DCL1","volume":"105","author":"Qu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1073\/pnas.0904086107","article-title":"RNAi-mediated viral immunity requires amplification of virus-derived siRNAs in Arabidopsis thaliana","volume":"107","author":"Wang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1126\/science.1128214","article-title":"Hierarchical action and inhibition of plant Dicer-like proteins in antiviral defense","volume":"313","author":"Deleris","year":"2006","journal-title":"Science"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.coviro.2020.12.001","article-title":"Recent advances in understanding plant antiviral RNAi and viral suppressors of RNAi","volume":"46","author":"Jin","year":"2020","journal-title":"Curr. Opin. Virol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1105\/tpc.111.092718","article-title":"Suppression of Arabidopsis ARGONAUTE1-mediated slicing, transgene-induced RNA silencing, and DNA methylation by distinct domains of the Cucumber mosaic virus 2b protein","volume":"24","author":"Duan","year":"2012","journal-title":"Plant Cell"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.3389\/fmicb.2016.01329","article-title":"CMV2b-AGO interaction is required for the suppression of RDR-Dependent antiviral silencing in Arabidopsis","volume":"7","author":"Fang","year":"2016","journal-title":"Front Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-313X.2011.04774.x","article-title":"Cucumber mosaic virus suppressor 2b binds to AGO4-related small RNAs and impairs AGO4 activities","volume":"69","author":"Hamera","year":"2012","journal-title":"Plant J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1101\/gad.1495506","article-title":"Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defense","volume":"20","author":"Zhang","year":"2006","journal-title":"Gene Dev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5762","DOI":"10.1002\/j.1460-2075.1995.tb00265.x","article-title":"A novel naturally occurring hybrid gene encoded by a plant RNA virus facilitates long distance virus movement","volume":"14","author":"Ding","year":"1995","journal-title":"EMBO J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1099\/vir.0.82927-0","article-title":"2b ORFs encoded by subgroup IB strains of cucumber mosaic virus induce differential virulence on Nicotiana species","volume":"88","author":"Du","year":"2007","journal-title":"J. Gen. Virol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1094\/MPMI.2002.15.7.647","article-title":"Virulence and differential local and systemic spread of Cucumber mosaic virus in tobacco are affected by the CMV 2b protein","volume":"15","author":"Soards","year":"2002","journal-title":"Mol. Plant Microbe Interact."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1105\/tpc.110.082305","article-title":"The 21-nucleotide, but not 22-nucleotide, viral secondary small interfering rnas direct potent antiviral defense by two cooperative argonautes in Arabidopsis thaliana","volume":"23","author":"Wang","year":"2011","journal-title":"Plant Cell"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jgg.2017.11.005","article-title":"Arabidopsis ENOR3 regulates RNAi-mediated antiviral defense","volume":"45","author":"Gao","year":"2018","journal-title":"J. Genet. Genom."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1104\/pp.17.01370","article-title":"Identification of a new host factor required for antiviral RNAi and amplification of viral siRNAs","volume":"176","author":"Guo","year":"2018","journal-title":"Plant Physiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v025.i01","article-title":"FactoMineR: An R package for multivariate analysis","volume":"25","author":"Le","year":"2008","journal-title":"J. Stat. Softw."},{"key":"ref_35","first-page":"10","article-title":"Differential analysis of count data\u2013the DESeq2 package","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: An R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics J. Integr. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1094\/MPMI-22-6-0642","article-title":"The role of the Cucumber mosaic virus 2b protein in viral movement and symptom induction","volume":"22","author":"Lewsey","year":"2009","journal-title":"Mol. Plant Microbe Interact."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.1364-3703.2010.00696.x","article-title":"Satellite RNA reduces expression of the 2b suppressor protein resulting in the attenuation of symptoms caused by Cucumber mosaic virus infection","volume":"12","author":"Hou","year":"2011","journal-title":"Mol. Plant Pathol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3389\/fpls.2017.00422","article-title":"Arabidopsis ALA1 and ALA2 mediate RNAi-based antiviral immunity","volume":"8","author":"Zhu","year":"2017","journal-title":"Front. Plant Sci."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Garcia-Ruiz, H., Carbonell, A., Hoyer, J.S., Fahlgren, N., Gilbert, K.B., Takeda, A., Giampetruzzi, A., Garcia Ruiz, M.T., McGinn, M.G., and Lowery, N. (2015). Roles and programming of Arabidopsis ARGONAUTE proteins during Turnip mosaic virus infection. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1004755"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Harvey, J.J., Lewsey, M.G., Patel, K., Westwood, J., Heimstadt, S., Carr, J.P., and Baulcombe, D.C. (2011). An antiviral defense role of AGO2 in plants. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0014639"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1104\/pp.111.178012","article-title":"ARGONAUTE2 mediates RNA-silencing antiviral defenses against Potato virus X in Arabidopsis","volume":"156","author":"Jaubert","year":"2011","journal-title":"Plant Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"6847","DOI":"10.1128\/JVI.00497-12","article-title":"Temperature-dependent survival of Turnip crinkle virus-infected arabidopsis plants relies on an RNA silencing-based defense that requires DCL2, AGO2, and HEN1","volume":"86","author":"Zhang","year":"2012","journal-title":"J. Virol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s10327-019-00845-x","article-title":"Plant defense systems against cucumber mosaic virus: Lessons learned from CMV-Arabidopsis interactions","volume":"85","author":"Ando","year":"2019","journal-title":"J. Gen. Plant Pathol."},{"key":"ref_46","first-page":"307","article-title":"Dominant resistance against plant viruses","volume":"5","author":"Butterbach","year":"2014","journal-title":"Front. Plant Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1105\/tpc.113.111658","article-title":"Plant immune responses against viruses: How does a virus cause disease?","volume":"25","author":"Mandadi","year":"2013","journal-title":"Plant Cell"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"746166","DOI":"10.3389\/fpls.2021.746166","article-title":"Response of Multiple Tissues to Drought Revealed by a Weighted Gene Co-Expression Network Analysis in Foxtail Millet [Setaria italica (L.) P. Beauv.]","volume":"12","author":"Zhang","year":"2022","journal-title":"Front. Plant Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.plaphy.2011.08.006","article-title":"Photosynthetic alterations of pea leaves infected systemically by pea enation mosaic virus: A coordinated decrease in efficiencies of CO2 assimilation and photosystem II photochemistry","volume":"49","author":"Kyselakova","year":"2011","journal-title":"Plant Physiol. Biochem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s42483-019-0042-6","article-title":"Comparative transcriptome analysis in Triticum aestivum infecting wheat dwarf virus reveals the effects of viral infection on phytohormone and photosynthesis metabolism pathways","volume":"2","author":"Liu","year":"2020","journal-title":"Phytopathol. Res."},{"key":"ref_51","first-page":"292299","article-title":"Coat protein mutations in an attenuated Cucumber mosaic virus encoding mutant 2b protein that lacks RNA silencing suppressor activity induces chlorosis with photosynthesis gene repression and chloroplast abnormalities in infected tobacco plants","volume":"457","author":"Mochizuki","year":"2014","journal-title":"Virology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1046\/j.1365-313X.1994.5060837.x","article-title":"Complex, localized changes in CO2 assimilation and starch content associated with the susceptible interaction between cucumber mosaic virus and a cucurbit host","volume":"5","author":"Maule","year":"1994","journal-title":"Plant J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/emboj\/cdg74","article-title":"Low temperature inhibits RNA silencing-mediated defence by the control of siRNA generation","volume":"22","author":"Szittya","year":"2003","journal-title":"EMBO J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1469-8137.2008.02627.x","article-title":"Virus infection improves drought tolerance","volume":"180","author":"Xu","year":"2008","journal-title":"New Phytol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1399-3054.2008.01189.x","article-title":"Effects of cucumber mosaic virus infection on electron transport and antioxidant system in chloroplasts and mitochondria of cucumber and tomato leaves","volume":"135","author":"Song","year":"2009","journal-title":"Physiol. Plant"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1104\/pp.19.00741","article-title":"ARGONAUTE1 and ARGONAUTE4 regulate gene expression and hypoxia tolerance","volume":"182","author":"Loreti","year":"2020","journal-title":"Plant Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1469-8137.2010.03451.x","article-title":"Hypoxia responsive gene expression is mediated by various subsets of transcription factors and miRNAs that are determined by the actual oxygen availability","volume":"190","author":"Licausi","year":"2011","journal-title":"New Phytol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/jxb\/erp296","article-title":"Hypoxia-responsive microRNAs and trans-acting small interfering RNAs in Arabidopsis","volume":"61","author":"Moldovan","year":"2010","journal-title":"J. Exp. Bot."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1399-3054.2012.01653.x","article-title":"Genome-wide identification and analysis of microRNA responding to long-term waterlogging in crown roots of maize seedlings","volume":"147","author":"Zhai","year":"2013","journal-title":"Physiol. Plant."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1038\/emboj.2010.215","article-title":"Plant virus-mediated induction of miR168 is associated with repression of ARGONAUTE1 accumulation","volume":"29","author":"Varallyay","year":"2010","journal-title":"EMBO J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1094\/MPMI-23-7-0835","article-title":"Disruption of two defensive signaling pathways by a viral RNA silencing suppressor","volume":"23","author":"Lewsey","year":"2010","journal-title":"Mol. Plant Microbe Interact."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/mpp.13005","article-title":"Priming for enhanced ARGONAUTE2 activation accompanies induced resistance to cucumber mosaic virus in Arabidopsis thaliana","volume":"22","author":"Ando","year":"2021","journal-title":"Mol. Plant Pathol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1023\/A:1026561029533","article-title":"Salicylic acid in the machinery of hypersensitive cell death and disease resistance","volume":"44","author":"Alvarez","year":"2000","journal-title":"Plant Mol. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1111\/nph.14302","article-title":"A core function of EDS1 with PAD4 is to protect the salicylic acid defense sector in Arabidopsis immunity","volume":"213","author":"Cui","year":"2017","journal-title":"New Phytol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s41586-021-03829-0","article-title":"The EDS1-PAD4-ADR1 node mediates Arabidopsis pattern-triggered immunity","volume":"598","author":"Pruitt","year":"2021","journal-title":"Nature"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1094\/MPMI.2003.16.8.669","article-title":"Targeted activation tagging of the Arabidopsis NBS-LRR gene, ADR1, conveys resistance to virulent pathogens","volume":"16","author":"Grant","year":"2003","journal-title":"Mol. Plant-Microbe Interact."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"18220","DOI":"10.1073\/pnas.1005225107","article-title":"Control of salicylic acid synthesis and systemic acquired resistance by two members of a plant-specific family of transcription factors","volume":"107","author":"Zhang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1111\/nph.17898","article-title":"FLA11 and FLA12 glycoproteins fine-tune stem secondary wall properties in response to mechanical stresses","volume":"233","author":"Ma","year":"2022","journal-title":"New Phytol"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s44154-021-00010-5","article-title":"SWO1 modulates cell wall integrity under salt stress by interacting with importin \u03b1 in Arabidopsis","volume":"1","author":"Wang","year":"2021","journal-title":"Stress Biol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Otulak-Koziel, K., Koziel, E., and Lockhart, B.E.L. (2018). Plant cell wall dynamics in compatible and incompatible potato response to infection caused by Potato Virus Y (PVYNTN). Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030862"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"396","DOI":"10.2174\/1389203721999201231212736","article-title":"Pathogenesis Related Proteins (PRs): From Cellular Mechanisms to Plant Defense","volume":"22","author":"Zribi","year":"2021","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1364-3703.2010.00675.x","article-title":"Expression of Arabidopsis pathogenesis-related genes during nematode infection","volume":"12","author":"Hamamouch","year":"2011","journal-title":"Mol. Plant Pathol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Anisimova, O.K., Shchennikova, A.V., Kochieva, E.Z., and Filyushin, M.A. (2021). Pathogenesis-Related Genes of PR1, PR2, PR4, and PR5 Families Are Involved in the Response to Fusarium Infection in Garlic (Allium sativum L.). Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22136688"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.micres.2018.04.008","article-title":"Pathogenesis-related proteins and peptides as promising tools for engineering plants with multiple stress tolerance","volume":"212\u2013213","author":"Ali","year":"2018","journal-title":"Microbiol. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/nph.16336","article-title":"Disruption of Arabidopsis neutral ceramidases 1 and 2 results in specific sphingolipid imbalances triggering different phytohormone-dependent plant cell death programmes","volume":"226","author":"Zienkiewicz","year":"2020","journal-title":"New Phytol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1126\/science.abn0650","article-title":"Recognition of pathogen-derived sphingolipids in Arabidopsis","volume":"376","author":"Kato","year":"2022","journal-title":"Science"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/7\/1582\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:55:32Z","timestamp":1760140532000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/7\/1582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,21]]},"references-count":76,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["v14071582"],"URL":"https:\/\/doi.org\/10.3390\/v14071582","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,21]]}}}