{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:19:27Z","timestamp":1790378367324,"version":"4.1.0"},"reference-count":45,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["AI127771"],"award-info":[{"award-number":["AI127771"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Powassan virus (POWV) is a tick-borne neuroinvasive flavivirus endemic to North America. It is generally transmitted by the tick, Ixodes scapularis. This species also transmits Borrelia burgdorferi, the causative agent of Lyme disease. Infection with B. burgdorferi can result in arthritis, carditis, and neuroborreliosis. These pathogens experience sylvatic overlap. To determine the risk of human exposure to coinfected ticks, the interactions between POWV and B. burgdorferi are assessed in laboratory-infected I. scapularis. Adult male and female I. scapularis ticks are orally inoculated with either both pathogens, POWV only, B. burgdorferi only, or uninfected media. After twenty-one days, the ticks are dissected, and RNA is extracted from their midguts and salivary glands. In infected midguts, the quantity of POWV in coinfected ticks was elevated compared to those with only POWV. In addition, the salivary glands of ticks with infected midguts had increased POWV dissemination to those with only POWV. RNA sequencing is performed to identify the potential mechanism for this pattern, which varies between the organs. Ixodes scapularis ticks are found to be capable of harboring both POWV and B. burgdorferi with a benefit to POWV replication and dissemination.<\/jats:p>","DOI":"10.3390\/v14071584","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T03:58:44Z","timestamp":1658462324000},"page":"1584","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Infection with Borrelia burgdorferi Increases the Replication and Dissemination of Coinfecting Powassan Virus in Ixodes scapularis Ticks"],"prefix":"10.3390","volume":"14","author":[{"given":"Charles E.","family":"Hart","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Upstate Medical University, Syracuse, NY 13210, USA"},{"name":"SUNY Center for Vector-Borne Diseases, Upstate Medical University, Syracuse, NY 13210, USA"},{"name":"Institute for Global Health and Translational Sciences, Upstate Medical University, Syracuse, NY 13210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank A.","family":"Middleton","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Upstate Medical University, Syracuse, NY 13210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4269-5993","authenticated-orcid":false,"given":"Saravanan","family":"Thangamani","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Upstate Medical University, Syracuse, NY 13210, USA"},{"name":"SUNY Center for Vector-Borne Diseases, Upstate Medical University, Syracuse, NY 13210, USA"},{"name":"Institute for Global Health and Translational Sciences, Upstate Medical University, Syracuse, NY 13210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"key":"ref_1","first-page":"1926","article-title":"Potential Role of Deer Tick Virus in Powassan Encephalitis Cases in Lyme Disease\u2013Endemic Areas of New York, USA","volume":"19","author":"Camargo","year":"2013","journal-title":"Emerg. 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