{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:44:54Z","timestamp":1791927894915,"version":"4.3.4"},"reference-count":32,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T00:00:00Z","timestamp":1658620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swiss National Science Foundation Professorship Grant to Gilles Wandeler","award":["PP00P3_176944"],"award-info":[{"award-number":["PP00P3_176944"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Hepatitis B virus (HBV) infection is the first cause of liver cirrhosis and cancer in West Africa. Although the exposure to additional environmental and infectious risk factors may lead to the faster progression of liver disease, few large-scale studies have evaluated the determinants of HBV-related liver fibrosis in the region. We used transient elastography to evaluate the prevalence of liver fibrosis and assessed the association between HBV markers and significant liver fibrosis in a cohort of people living with HBV in Dakar, Senegal. The prevalence of significant liver fibrosis was 12.5% (95% confidence interval [CI] 9.6%\u201315.9%) among 471 people with HBV mono-infection (pwHBV) and 6.4% (95% CI 2.6%\u201312.7%) in 110 people with HIV\/HBV co-infection (pwHIV\/HBV) on tenofovir-containing antiretroviral therapy (p = 0.07). An HBV viral load &gt; 2000 IU\/mL was found in 133 (28.3%) pwHBV and 5 (4.7%) pwHIV\/HBV, and was associated with significant liver fibrosis (adjusted odds ratio (aOR) 1.95, 95% CI 1.04\u20133.66). Male participants (aOR 4.32, 95% CI 2.01\u20138.96) and those with elevated ALT (aOR 4.32, 95% CI 2.01\u20138.96) were especially at risk of having significant liver fibrosis. Our study shows that people with an HBV viral load above 2000 IU\/mL have a two-fold increase in the risk of liver fibrosis and may have to be considered for antiviral therapy, independent of other disease parameters.<\/jats:p>","DOI":"10.3390\/v14081614","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T04:52:47Z","timestamp":1658724767000},"page":"1614","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prevalence and Predictors of Liver Fibrosis in People Living with Hepatitis B in Senegal"],"prefix":"10.3390","volume":"14","author":[{"given":"Adri\u00e0","family":"Ram\u00edrez Mena","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Bern University Hospital, University of Bern, 3010 Bern, Switzerland"},{"name":"Graduate School of Health Sciences, University of Bern, 3010 Bern, Switzerland"},{"name":"Service de Maladies Infectieuses et Tropicales, Fann University Hospital, Dakar 10700, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ndeye Fatou","family":"Ngom","sequence":"additional","affiliation":[{"name":"Centre de Traitement Ambulatoire de Fann, University Hospital Fann, Dakar 10700, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judica\u00ebl","family":"Tine","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses et Tropicales, Fann University Hospital, Dakar 10700, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kine","family":"Ndiaye","sequence":"additional","affiliation":[{"name":"Centre de Traitement Ambulatoire de Fann, University Hospital Fann, Dakar 10700, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Fortes","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses et Tropicales, Fann University Hospital, Dakar 10700, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ousseynou","family":"Ndiaye","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Recherche et Formation Clinique \u00e0 la Prise en Charge de Fann, Fann University Hospital, Dakar 10700, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maguette","family":"Fall","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses et Tropicales, Fann University Hospital, Dakar 10700, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assietou","family":"Gaye","sequence":"additional","affiliation":[{"name":"Centre de Traitement Ambulatoire de Fann, University Hospital Fann, Dakar 10700, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daye","family":"Ka","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses et Tropicales, Fann University Hospital, Dakar 10700, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moussa","family":"Seydi","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses et Tropicales, Fann University Hospital, Dakar 10700, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Wandeler","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Bern University Hospital, University of Bern, 3010 Bern, Switzerland"},{"name":"Service de Maladies Infectieuses et Tropicales, Fann University Hospital, Dakar 10700, Senegal"},{"name":"Institute of Social and Preventive Medicine, University of Bern, 3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,24]]},"reference":[{"key":"ref_1","unstructured":"GBD 2017 Cirrhosis Collaborators (2020). 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