{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:16:22Z","timestamp":1789024582157,"version":"build-2803163510"},"reference-count":42,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Israel Institute for Biological Research (IIBR)","award":["SB\/145"],"award-info":[{"award-number":["SB\/145"]}]},{"name":"Israel Institute for Biological Research (IIBR)","award":["695437"],"award-info":[{"award-number":["695437"]}]},{"name":"Israel Institute for Biological Research (IIBR)","award":["1800\/19"],"award-info":[{"award-number":["1800\/19"]}]},{"name":"Israel Institute for Biological Research (IIBR)","award":["1226\/13"],"award-info":[{"award-number":["1226\/13"]}]},{"name":"European Research Council (ERC)","award":["SB\/145"],"award-info":[{"award-number":["SB\/145"]}]},{"name":"European Research Council (ERC)","award":["695437"],"award-info":[{"award-number":["695437"]}]},{"name":"European Research Council (ERC)","award":["1800\/19"],"award-info":[{"award-number":["1800\/19"]}]},{"name":"European Research Council (ERC)","award":["1226\/13"],"award-info":[{"award-number":["1226\/13"]}]},{"name":"Eu 2020 EDIT consortium","award":["SB\/145"],"award-info":[{"award-number":["SB\/145"]}]},{"name":"Eu 2020 EDIT consortium","award":["695437"],"award-info":[{"award-number":["695437"]}]},{"name":"Eu 2020 EDIT consortium","award":["1800\/19"],"award-info":[{"award-number":["1800\/19"]}]},{"name":"Eu 2020 EDIT consortium","award":["1226\/13"],"award-info":[{"award-number":["1226\/13"]}]},{"name":"Israeli Science Foundation","award":["SB\/145"],"award-info":[{"award-number":["SB\/145"]}]},{"name":"Israeli Science Foundation","award":["695437"],"award-info":[{"award-number":["695437"]}]},{"name":"Israeli Science Foundation","award":["1800\/19"],"award-info":[{"award-number":["1800\/19"]}]},{"name":"Israeli Science Foundation","award":["1226\/13"],"award-info":[{"award-number":["1226\/13"]}]},{"name":"Thompson Family Foundation","award":["SB\/145"],"award-info":[{"award-number":["SB\/145"]}]},{"name":"Thompson Family Foundation","award":["695437"],"award-info":[{"award-number":["695437"]}]},{"name":"Thompson Family Foundation","award":["1800\/19"],"award-info":[{"award-number":["1800\/19"]}]},{"name":"Thompson Family Foundation","award":["1226\/13"],"award-info":[{"award-number":["1226\/13"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The COVID-19 pandemic caused by the SARS-CoV-2 infection induced lung inflammation characterized by cytokine storm and fulminant immune response of both resident and migrated immune cells, accelerating alveolar damage. In this work we identified members of the matrix metalloprotease (MMPs) family associated with lung extra-cellular matrix (ECM) destruction using K18-hACE2-transgenic mice (K18-hACE2) infected intranasally with SARS-CoV-2. Five days post infection, the lungs exhibited overall alveolar damage of epithelial cells and massive leukocytes infiltration. A substantial pulmonary increase in MMP8, MMP9, and MMP14 in the lungs post SARS-CoV-2 infection was associated with degradation of ECM components including collagen, laminin, and proteoglycans. The process of tissue damage and ECM degradation during SARS-CoV-2 lung infection is suggested to be associated with activity of members of the MMPs family, which in turn may be used as a therapeutic intervention.<\/jats:p>","DOI":"10.3390\/v14081627","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T01:41:16Z","timestamp":1659058876000},"page":"1627","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Matrix Metalloproteinases Expression Is Associated with SARS-CoV-2-Induced Lung Pathology and Extracellular-Matrix Remodeling in K18-hACE2 Mice"],"prefix":"10.3390","volume":"14","author":[{"given":"Hila","family":"Gutman","sequence":"first","affiliation":[{"name":"Israel Institute for Biological Research, Ness Ziona P.O. Box 19, Israel"},{"name":"Department of Biological Regulation, Weizmann Institute of Science, Herzel 234, Rehovot P.O. Box 26, Israel"},{"name":"Department of Biomolecular Sciences, Weizmann Institute of Science, Herzel 234, Rehovot P.O. Box 26, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Aftalion","sequence":"additional","affiliation":[{"name":"Israel Institute for Biological Research, Ness Ziona P.O. Box 19, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Melamed","sequence":"additional","affiliation":[{"name":"Israel Institute for Biological Research, Ness Ziona P.O. Box 19, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boaz","family":"Politi","sequence":"additional","affiliation":[{"name":"Israel Institute for Biological Research, Ness Ziona P.O. Box 19, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinat","family":"Nevo","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, Weizmann Institute of Science, Herzel 234, Rehovot P.O. Box 26, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8456-8116","authenticated-orcid":false,"given":"Sapir","family":"Havusha-Laufer","sequence":"additional","affiliation":[{"name":"Department of Biological Regulation, Weizmann Institute of Science, Herzel 234, Rehovot P.O. Box 26, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0664-8628","authenticated-orcid":false,"given":"Hagit","family":"Achdout","sequence":"additional","affiliation":[{"name":"Israel Institute for Biological Research, Ness Ziona P.O. Box 19, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gur","sequence":"additional","affiliation":[{"name":"Israel Institute for Biological Research, Ness Ziona P.O. Box 19, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0246-4477","authenticated-orcid":false,"given":"Tomer","family":"Israely","sequence":"additional","affiliation":[{"name":"Israel Institute for Biological Research, Ness Ziona P.O. Box 19, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomit","family":"Dachir","sequence":"additional","affiliation":[{"name":"Israel Institute for Biological Research, Ness Ziona P.O. Box 19, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5685-293X","authenticated-orcid":false,"given":"Emanuelle","family":"Mamroud","sequence":"additional","affiliation":[{"name":"Israel Institute for Biological Research, Ness Ziona P.O. Box 19, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irit","family":"Sagi","sequence":"additional","affiliation":[{"name":"Department of Biological Regulation, Weizmann Institute of Science, Herzel 234, Rehovot P.O. Box 26, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaron","family":"Vagima","sequence":"additional","affiliation":[{"name":"Israel Institute for Biological Research, Ness Ziona P.O. Box 19, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1001\/jamainternmed.2020.0994","article-title":"Risk Factors Associated with Acute Respiratory Distress Syndrome and Death in Patients with Coronavirus Disease 2019 Pneumonia in Wuhan, China","volume":"180","author":"Wu","year":"2020","journal-title":"JAMA Intern. 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