{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:31:48Z","timestamp":1791495108213,"version":"4.3.4"},"reference-count":232,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program","award":["2021YFD1801105"],"award-info":[{"award-number":["2021YFD1801105"]}]},{"name":"National Key Research and Development Program","award":["204200510015"],"award-info":[{"award-number":["204200510015"]}]},{"name":"National Key Research and Development Program","award":["211110111000"],"award-info":[{"award-number":["211110111000"]}]},{"name":"Zhongyuan High Level Talents Special Support Plan","award":["2021YFD1801105"],"award-info":[{"award-number":["2021YFD1801105"]}]},{"name":"Zhongyuan High Level Talents Special Support Plan","award":["204200510015"],"award-info":[{"award-number":["204200510015"]}]},{"name":"Zhongyuan High Level Talents Special Support Plan","award":["211110111000"],"award-info":[{"award-number":["211110111000"]}]},{"name":"Henan open competition mechanism to select the best candidates Program","award":["2021YFD1801105"],"award-info":[{"award-number":["2021YFD1801105"]}]},{"name":"Henan open competition mechanism to select the best candidates Program","award":["204200510015"],"award-info":[{"award-number":["204200510015"]}]},{"name":"Henan open competition mechanism to select the best candidates Program","award":["211110111000"],"award-info":[{"award-number":["211110111000"]}]},{"name":"Fang\u2019s family (Hong Kong) foundation","award":["2021YFD1801105"],"award-info":[{"award-number":["2021YFD1801105"]}]},{"name":"Fang\u2019s family (Hong Kong) foundation","award":["204200510015"],"award-info":[{"award-number":["204200510015"]}]},{"name":"Fang\u2019s family (Hong Kong) foundation","award":["211110111000"],"award-info":[{"award-number":["211110111000"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Pseudorabies (PR), also called Aujeszky\u2019s disease (AD), is a highly infectious viral disease which is caused by pseudorabies virus (PRV). It has been nearly 200 years since the first PR case occurred. Currently, the virus can infect human beings and various mammals, including pigs, sheep, dogs, rabbits, rodents, cattle and cats, and among them, pigs are the only natural host of PRV infection. PRV is characterized by reproductive failure in pregnant sows, nervous disorders in newborn piglets, and respiratory distress in growing pigs, resulting in serious economic losses to the pig industry worldwide. Due to the extensive application of the attenuated vaccine containing the Bartha-K61 strain, PR was well controlled. With the variation of PRV strain, PR re-emerged and rapidly spread in some countries, especially China. Although researchers have been committed to the design of diagnostic methods and the development of vaccines in recent years, PR is still an important infectious disease and is widely prevalent in the global pig industry. In this review, we introduce the structural composition and life cycle of PRV virions and then discuss the latest findings on PRV pathogenesis, following the molecular characteristic of PRV and the summary of existing diagnosis methods. Subsequently, we also focus on the latest clinical progress in the prevention and control of PRV infection via the development of vaccines, traditional herbal medicines and novel small RNAs. Lastly, we provide an outlook on PRV eradication.<\/jats:p>","DOI":"10.3390\/v14081638","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T01:41:16Z","timestamp":1659058876000},"page":"1638","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":147,"title":["Pseudorabies Virus: From Pathogenesis to Prevention Strategies"],"prefix":"10.3390","volume":"14","author":[{"given":"Hui-Hua","family":"Zheng","sequence":"first","affiliation":[{"name":"Zhengzhou Major Pig Disease Prevention and Control Laboratory, College of Veterinary Medicine, Henan Agricultural University, Zhengdong New District Longzi Lake 15#, Zhengzhou 450046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Fei","family":"Fu","sequence":"additional","affiliation":[{"name":"Zhengzhou Major Pig Disease Prevention and Control Laboratory, College of Veterinary Medicine, Henan Agricultural University, Zhengdong New District Longzi Lake 15#, Zhengzhou 450046, China"},{"name":"College of Life Science and Engineering, Henan University of Urban Construction, Pingdingshan 467044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8245-3999","authenticated-orcid":false,"given":"Hong-Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhengzhou Major Pig Disease Prevention and Control Laboratory, College of Veterinary Medicine, Henan Agricultural University, Zhengdong New District Longzi Lake 15#, Zhengzhou 450046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Ya","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of \u201cRunliang\u201d Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"104835","DOI":"10.1016\/j.meegid.2021.104835","article-title":"Seroprevalence investigation and genetic analysis of pseudorabies virus within pig populations in Henan province of China during 2018\u20132019","volume":"92","author":"Zheng","year":"2021","journal-title":"Infect. 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