{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:25:56Z","timestamp":1790663156301,"version":"4.1.0"},"reference-count":82,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T00:00:00Z","timestamp":1659225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"InTechThrace: Integrated Technologies in biomedical research: multilevel biomarker analysis in Thrace","award":["5047285"],"award-info":[{"award-number":["5047285"]}]},{"name":"InTechThrace: Integrated Technologies in biomedical research: multilevel biomarker analysis in Thrace","award":["2014-2020"],"award-info":[{"award-number":["2014-2020"]}]},{"name":"European Regional Development Fund (ERDF) and national resources","award":["5047285"],"award-info":[{"award-number":["5047285"]}]},{"name":"European Regional Development Fund (ERDF) and national resources","award":["2014-2020"],"award-info":[{"award-number":["2014-2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Hepatitis C virus is the major cause of chronic liver diseases and the only cytoplasmic RNA virus known to be oncogenic in humans. The viral genome gives rise to ten mature proteins and to additional proteins, which are the products of alternative translation initiation mechanisms. A protein\u2014known as ARFP (alternative reading frame protein) or Core+1 protein\u2014is synthesized by an open reading frame overlapping the HCV Core coding region in the (+1) frame of genotype 1a. Almost 20 years after its discovery, we still know little of the biological role of the ARFP\/Core+1 protein. Here, our differential proteomic analysis of stable hepatoma cell lines expressing the Core+1\/Long isoform of HCV-1a relates the expression of the Core+1\/Long isoform with the progression of the pathology of HCV liver disease to cancer.<\/jats:p>","DOI":"10.3390\/v14081694","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T23:49:27Z","timestamp":1659397767000},"page":"1694","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Proteomic Approach to Study the Biological Role of Hepatitis C Virus Protein Core+1\/ARFP"],"prefix":"10.3390","volume":"14","author":[{"given":"Vasileios","family":"Vrazas","sequence":"first","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Virology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4648-1578","authenticated-orcid":false,"given":"Savvina","family":"Moustafa","sequence":"additional","affiliation":[{"name":"Clinical Immunology-Rheumatology Unit, 2nd Department of Medicine and Laboratory, Hippokration General Hospital of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0063-3559","authenticated-orcid":false,"given":"Manousos","family":"Makridakis","sequence":"additional","affiliation":[{"name":"Centre of Basic Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3004-8104","authenticated-orcid":false,"given":"Ioannis","family":"Karakasiliotis","sequence":"additional","affiliation":[{"name":"Laboratory of Biology, Department of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3284-5713","authenticated-orcid":false,"given":"Antonia","family":"Vlahou","sequence":"additional","affiliation":[{"name":"Centre of Basic Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope","family":"Mavromara","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Virology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2546-4381","authenticated-orcid":false,"given":"Katerina R.","family":"Katsani","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Virology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.tim.2019.01.001","article-title":"Hepatitis C Virus","volume":"27","author":"Pietschmann","year":"2019","journal-title":"Trends Microbiol."},{"key":"ref_2","unstructured":"World Health Organization (2017). 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