{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:53:37Z","timestamp":1791568417485,"version":"4.3.4"},"reference-count":49,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Carlos Chagas Filho Foundation","award":["E-26\/200.815\/2021"],"award-info":[{"award-number":["E-26\/200.815\/2021"]}]},{"name":"Carlos Chagas Filho Foundation","award":["E-26\/010.000981\/2019"],"award-info":[{"award-number":["E-26\/010.000981\/2019"]}]},{"name":"Carlos Chagas Filho Foundation","award":["E-26\/010.002362\/2019"],"award-info":[{"award-number":["E-26\/010.002362\/2019"]}]},{"name":"Carlos Chagas Filho Foundation","award":["E-26\/211.269\/2021"],"award-info":[{"award-number":["E-26\/211.269\/2021"]}]},{"name":"Carlos Chagas Filho Foundation","award":["E-26\/\/211.207\/2021"],"award-info":[{"award-number":["E-26\/\/211.207\/2021"]}]},{"name":"Carlos Chagas Filho Foundation","award":["E-26\/202.320\/2021"],"award-info":[{"award-number":["E-26\/202.320\/2021"]}]},{"name":"Carlos Chagas Filho Foundation","award":["301069\/2018-2"],"award-info":[{"award-number":["301069\/2018-2"]}]},{"name":"CNPq","award":["E-26\/200.815\/2021"],"award-info":[{"award-number":["E-26\/200.815\/2021"]}]},{"name":"CNPq","award":["E-26\/010.000981\/2019"],"award-info":[{"award-number":["E-26\/010.000981\/2019"]}]},{"name":"CNPq","award":["E-26\/010.002362\/2019"],"award-info":[{"award-number":["E-26\/010.002362\/2019"]}]},{"name":"CNPq","award":["E-26\/211.269\/2021"],"award-info":[{"award-number":["E-26\/211.269\/2021"]}]},{"name":"CNPq","award":["E-26\/\/211.207\/2021"],"award-info":[{"award-number":["E-26\/\/211.207\/2021"]}]},{"name":"CNPq","award":["E-26\/202.320\/2021"],"award-info":[{"award-number":["E-26\/202.320\/2021"]}]},{"name":"CNPq","award":["301069\/2018-2"],"award-info":[{"award-number":["301069\/2018-2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) from Flavivirus. In 2015, Brazil and other Latin American countries experienced an outbreak of ZIKV infections associated with severe neurological disorders such as Guillain\u2013Barre syndrome (GBS), encephalopathy, and encephalitis. Here, a complete mechanical and structural analysis of the ZIKV has been performed using Atomic Force Microscopy (AFM). AFM analysis corroborated the virus mean size (~50 nm) and icosahedral geometry and revealed high mechanical resistance of both: the viral surface particle (~200 kPa) and its internal content (~800 kPa). The analysis demonstrated the detailed organization of the nucleocapsid structure (such as RNA strips). An interesting finding was the discovery that ZIKV has no surface self-assembling property. These results can contribute to the development of future treatment candidates and circumscribe the magnitude of viral transmission.<\/jats:p>","DOI":"10.3390\/v14081727","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T09:47:06Z","timestamp":1660124826000},"page":"1727","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Zika Virus (ZIKV): A New Perspective on the Nanomechanical and Structural Properties"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3893-1292","authenticated-orcid":false,"given":"Maria Luiza","family":"de Araujo Dorneles","sequence":"first","affiliation":[{"name":"Laboratory of Biophysics and Nanosystems, Physics Department, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds 65020070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0952-3927","authenticated-orcid":false,"given":"Ruana","family":"Cardoso-Lima","sequence":"additional","affiliation":[{"name":"Laboratory of Biophysics and Nanosystems, Physics Department, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds 65020070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2524-4434","authenticated-orcid":false,"given":"Pedro Filho Noronha","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Federal University of Cear\u00e1, Fortaleza 60440900, Brazil"},{"name":"Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza 60440900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4536-891X","authenticated-orcid":false,"given":"Daniela","family":"Santoro Rosa","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Parasitology, Federal University of S\u00e3o Paulo, S\u00e3o Paulo 04023062, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3416-054X","authenticated-orcid":false,"given":"Tais Monteiro","family":"Magne","sequence":"additional","affiliation":[{"name":"Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro 21941906, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0905-481X","authenticated-orcid":false,"given":"Ralph","family":"Santos-Oliveira","sequence":"additional","affiliation":[{"name":"Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro 21941906, Brazil"},{"name":"Laboratory of Nanoradiopharmacy, Rio de Janeiro State University, Rio de Janeiro 23070200, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8210-2016","authenticated-orcid":false,"given":"Luciana Magalh\u00e3es Rebelo","family":"Alencar","sequence":"additional","affiliation":[{"name":"Laboratory of Biophysics and Nanosystems, Physics Department, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds 65020070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/s41564-020-0714-0","article-title":"The Continued Threat of Emerging Flaviviruses","volume":"5","author":"Pierson","year":"2020","journal-title":"Nat. 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