{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T10:28:59Z","timestamp":1779100139514,"version":"3.51.4"},"reference-count":163,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T00:00:00Z","timestamp":1660176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jiangsu Province\u2019s Key Research and Development plan (modern Agriculture)","award":["BE2020407"],"award-info":[{"award-number":["BE2020407"]}]},{"name":"Jiangsu Province\u2019s Key Research and Development plan (modern Agriculture)","award":["00000221010"],"award-info":[{"award-number":["00000221010"]}]},{"name":"Jiangsu Province\u2019s Key Research and Development plan (modern Agriculture)","award":["NSF2022CB04"],"award-info":[{"award-number":["NSF2022CB04"]}]},{"name":"Jiangsu Province\u2019s Key Research and Development plan (modern Agriculture)","award":["NSF2022CB25"],"award-info":[{"award-number":["NSF2022CB25"]}]},{"name":"Jiangsu Province high education connotation construction fund","award":["BE2020407"],"award-info":[{"award-number":["BE2020407"]}]},{"name":"Jiangsu Province high education connotation construction fund","award":["00000221010"],"award-info":[{"award-number":["00000221010"]}]},{"name":"Jiangsu Province high education connotation construction fund","award":["NSF2022CB04"],"award-info":[{"award-number":["NSF2022CB04"]}]},{"name":"Jiangsu Province high education connotation construction fund","award":["NSF2022CB25"],"award-info":[{"award-number":["NSF2022CB25"]}]},{"name":"Jiangsu Agri-animal Husbandry Vocational College","award":["BE2020407"],"award-info":[{"award-number":["BE2020407"]}]},{"name":"Jiangsu Agri-animal Husbandry Vocational College","award":["00000221010"],"award-info":[{"award-number":["00000221010"]}]},{"name":"Jiangsu Agri-animal Husbandry Vocational College","award":["NSF2022CB04"],"award-info":[{"award-number":["NSF2022CB04"]}]},{"name":"Jiangsu Agri-animal Husbandry Vocational College","award":["NSF2022CB25"],"award-info":[{"award-number":["NSF2022CB25"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Pseudorabies virus (PRV) is the causative agent of pseudorabies (PR), infecting most mammals and some birds. It has been prevalent around the world and caused huge economic losses to the swine industry since its discovery. At present, the prevention of PRV is mainly through vaccination; there are few specific antivirals against PRV, but it is possible to treat PRV infection effectively with drugs. In recent years, some drugs have been reported to treat PR; however, the variety of anti-pseudorabies drugs is limited, and the underlying mechanism of the antiviral effect of some drugs is unclear. Therefore, it is necessary to explore new drug targets for PRV and develop economic and efficient drug resources for prevention and control of PRV. This review will focus on the research progress in drugs and drug targets against PRV in recent years, and discuss the future research prospects of anti-PRV drugs.<\/jats:p>","DOI":"10.3390\/v14081753","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T01:51:11Z","timestamp":1660269071000},"page":"1753","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Progress of Research into Novel Drugs and Potential Drug Targets against Porcine Pseudorabies Virus"],"prefix":"10.3390","volume":"14","author":[{"given":"Mo","family":"Zhou","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory for High-Tech Research and Development of Veterinary Biopharmaceuticals, Jiangsu Agri-Animal Husbandry Vocational College, Taizhou 225306, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4333-6423","authenticated-orcid":false,"given":"Muhammad","family":"Abid","sequence":"additional","affiliation":[{"name":"Viral Oncogenesis Group, The Pirbright Institute, Ash Road Pirbright, Woking, Surrey GU24 0NF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinuo","family":"Cao","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory for High-Tech Research and Development of Veterinary Biopharmaceuticals, Jiangsu Agri-Animal Husbandry Vocational College, Taizhou 225306, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanyuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory for High-Tech Research and Development of Veterinary Biopharmaceuticals, Jiangsu Agri-Animal Husbandry Vocational College, Taizhou 225306, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,11]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"In vitro anti-PRV activity of dihydromyricetin from Ampelopsis grossedentata","volume":"29","author":"Sun","year":"2021","journal-title":"Nat. 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