{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:53:53Z","timestamp":1790024033580,"version":"4.0.1"},"reference-count":189,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"C.N.D.d.S.","award":["307176-2018-5"],"award-info":[{"award-number":["307176-2018-5"]}]},{"name":"C.N.D.d.S.","award":["312671\/2020-2"],"award-info":[{"award-number":["312671\/2020-2"]}]},{"name":"C.N.D.d.S.","award":["205096\/2018-2"],"award-info":[{"award-number":["205096\/2018-2"]}]},{"name":"J.B.","award":["307176-2018-5"],"award-info":[{"award-number":["307176-2018-5"]}]},{"name":"J.B.","award":["312671\/2020-2"],"award-info":[{"award-number":["312671\/2020-2"]}]},{"name":"J.B.","award":["205096\/2018-2"],"award-info":[{"award-number":["205096\/2018-2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Mayaro virus is an emerging arbovirus that causes nonspecific febrile illness or arthralgia syndromes similar to the Chikungunya virus, a virus closely related from the Togaviridae family. MAYV outbreaks occur more frequently in the northern and central-western states of Brazil; however, in recent years, virus circulation has been spreading to other regions. Due to the undifferentiated initial clinical symptoms between MAYV and other endemic pathogenic arboviruses with geographic overlapping, identification of patients infected by MAYV might be underreported. Additionally, the lack of specific prophylactic approaches or antiviral drugs limits the pharmacological management of patients to treat symptoms like pain and inflammation, as is the case with most pathogenic alphaviruses. In this context, this review aims to present the state-of-the-art regarding the screening and development of compounds\/molecules which may present anti-MAYV activity and infection inhibition.<\/jats:p>","DOI":"10.3390\/v14081787","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T03:15:27Z","timestamp":1660706127000},"page":"1787","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Mayaro Virus: The State-of-the-Art for Antiviral Drug Development"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9769-3699","authenticated-orcid":false,"given":"Ana Paula","family":"Andreolla","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Virologia Molecular, Instituto Carlos Chagas, ICC\/Fiocruz, Curitiba 81350-010, PR, Brazil"},{"name":"Departamento de Biologia Celular e Molecular, Universidade Federal do Paran\u00e1, Curitiba 81530-900, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra Abel","family":"Borges","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisas em Virologia e Imunologia, Universidade Federal de Alagoas, Macei\u00f3 57072-900, AL, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliano","family":"Bordignon","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Virologia Molecular, Instituto Carlos Chagas, ICC\/Fiocruz, Curitiba 81350-010, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Nunes","family":"Duarte dos Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Virologia Molecular, Instituto Carlos Chagas, ICC\/Fiocruz, Curitiba 81350-010, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"key":"ref_1","unstructured":"Monath, T.P. 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