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Many of these studies were prospective and focused mainly on Rhinolophus bats that could be related to zoonotic events. However, other species of bats that are part of ecosystems identified as virus diversity hotspots have not been studied in-depth. We analyzed the virome of a group of Myotis fimbriatus bats collected from the Yunnan Province during 2020. The virome of M. fimbriatus revealed the presence of families of pathogenic viruses such as Coronavirus, Astrovirus, Mastadenovirus, and Picornavirus, among others. The viral sequences identified in M. fimbriatus were characterized by significant divergence from other known viral sequences of bat origin. Complex phylogenetic landscapes implying a tendency of co-specificity and relationships with viruses from other mammals characterize these groups. The most prevalent and abundant virus in M. fimbriatus individuals was an alphacoronavirus. The genome of this virus shows evidence of recombination and is likely the product of ancestral host-switch. The close phylogenetic and ecological relationship of some species of the Myotis genus in China may have played an important role in the emergence of this alphacoronavirus.<\/jats:p>","DOI":"10.3390\/v14091899","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T02:09:36Z","timestamp":1661911776000},"page":"1899","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Myotis fimbriatus Virome, a Window to Virus Diversity and Evolution in the Genus Myotis"],"prefix":"10.3390","volume":"14","author":[{"given":"Alix","family":"Armero","sequence":"first","affiliation":[{"name":"Unit of Discovery and Molecular Characterization of Pathogens, Centre for Microbes, Development, and Health, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiya","family":"Li","sequence":"additional","affiliation":[{"name":"Viral Hemorrhagic Fevers Research Unit, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrina Mae","family":"Bienes","sequence":"additional","affiliation":[{"name":"Unit of Discovery and Molecular Characterization of Pathogens, Centre for Microbes, Development, and Health, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Chen","sequence":"additional","affiliation":[{"name":"Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Jinghong 666303, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihao","family":"Li","sequence":"additional","affiliation":[{"name":"Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Jinghong 666303, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiman","family":"Xu","sequence":"additional","affiliation":[{"name":"Viral Hemorrhagic Fevers Research Unit, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Chen","sequence":"additional","affiliation":[{"name":"Viral Hemorrhagic Fevers Research Unit, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice C.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Jinghong 666303, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Berthet","sequence":"additional","affiliation":[{"name":"Unit of Discovery and Molecular Characterization of Pathogens, Centre for Microbes, Development, and Health, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China"},{"name":"Cellule d\u2019Intervention Biologique d\u2019Urgence, Unit\u00e9 Environnement et Risque Infectieux, Institut Pasteur, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Wong","sequence":"additional","affiliation":[{"name":"Viral Hemorrhagic Fevers Research Unit, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7070","DOI":"10.1128\/JVI.00631-14","article-title":"Identification of Diverse Alphacoronaviruses and Genomic Characterization of a Novel Severe Acute Respiratory Syndrome-like Coronavirus from Bats in China","volume":"88","author":"He","year":"2014","journal-title":"J. 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