{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:06:01Z","timestamp":1760231161791,"version":"build-2065373602"},"reference-count":19,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (KNRF)","doi-asserted-by":"publisher","award":["2019R1G1A1010388","2017R1C1B5076471","2021R1A4A1031380","2022M3A9H1016077"],"award-info":[{"award-number":["2019R1G1A1010388","2017R1C1B5076471","2021R1A4A1031380","2022M3A9H1016077"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Hepatitis B virus (HBV) infection carries a risk of liver cancer and extrahepatic malignancy. However, the incidence trend and clinical course of malignant lymphoma (ML) in HBV patients are not well known. Data about ML newly diagnosed in chronic hepatitis B (CHB) patients from 2003 to 2016 were collected from National Health Insurance Service claims. A total of 13,942 CHB patients were newly diagnosed with ML from 2003 to 2016. The number of patients increased 3.8 times, from 442 in 2003 to 1711 in 2016. The 2-year survival rate of all patients was 76.8%, and the 5-year survival rate was 69.8%. The survival rate of patients taking antivirals due to high viral activity before their diagnosis with ML was significantly lower than that of patients with lower viral activity without antivirals (1 yr\u201477.3%, 3 yr\u201464.5%, and 5 yr\u201458.3% vs. 1 yr\u201484.0%, 3 yr\u201473.4%, and 5 yr\u201468.0%, respectively). The survival rate of patients with liver cirrhosis (LC) at baseline was significantly lower than that of those without LC. Cirrhotic patients taking antivirals before ML diagnosis had a worse prognosis than who did not. High viral activity in CHB patients with ML seems to be useful in predicting the prognosis for survival.<\/jats:p>","DOI":"10.3390\/v14091943","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T03:55:38Z","timestamp":1662004538000},"page":"1943","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic Hepatitis B Viral Activity Enough to Take Antiviral Drug Could Predict the Survival Rate in Malignant Lymphoma"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8854-5205","authenticated-orcid":false,"given":"Kwang-Il","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Kosin University College of Medicine, Busan 49267, Korea"},{"name":"Chang Kee-Ryo Memorial Liver Institute, Kosin University College of Medicine, Busan 49267, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6014-7977","authenticated-orcid":false,"given":"Jae-Cheol","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 44033, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kosin University College of Medicine, Busan 49267, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9482-4526","authenticated-orcid":false,"given":"Jee-Yeong","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Kosin University College of Medicine, Busan 49267, Korea"},{"name":"Institute for Medical Science, Kosin University College of Medicine, Busan 49267, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangjin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Statistics, Pusan National University, Busan 46241, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5974-6884","authenticated-orcid":false,"given":"Ho-Sup","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kosin University College of Medicine, Busan 49267, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/S0140-6736(15)61412-X","article-title":"Estimations of worldwide prevalence of chronic hepatitis B virus infection: A systematic review of data published between 1965 and 2013","volume":"386","author":"Schweitzer","year":"2015","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/d41586-018-07592-7","article-title":"The silent epidemic killing more people than HIV, malaria or TB","volume":"564","year":"2018","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Korean Association for the Study of the Liver (2019). KASL clinical practice guidelines for management of chronic hepatitis B. Clin. Mol. Hepatol., 25, 93\u2013159.","DOI":"10.3350\/cmh.2019.1002"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1002\/hep.30246","article-title":"Advancing Age and Comorbidity in a US Insured Population-Based Cohort of Patients With Chronic Hepatitis B","volume":"69","author":"Nguyen","year":"2019","journal-title":"Hepatology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1111\/jvh.13304","article-title":"Incidence of extrahepatic cancers among individuals with chronic hepatitis B or C virus infection: A nationwide cohort study","volume":"27","author":"Hong","year":"2020","journal-title":"J. Viral Hepat."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Kamiza, A.B., Su, F.H., Wang, W.C., Sung, F.C., Chang, S.N., and Yeh, C.C. (2016). Chronic hepatitis infection is associated with extrahepatic cancer development: A nationwide population-based study in Taiwan. BMC Cancer, 16.","DOI":"10.1186\/s12885-016-2918-5"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S1470-2045(10)70167-4","article-title":"Hepatitis B virus infection and risk of non-Hodgkin lymphoma in South Korea: A cohort study","volume":"11","author":"Engels","year":"2010","journal-title":"Lancet Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1002\/hep.29800","article-title":"Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance","volume":"67","author":"Terrault","year":"2018","journal-title":"Hepatology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3350\/cmh.2019.0065","article-title":"Trends in the prevalence of chronic liver disease in the Korean adult population, 1998\u20132017","volume":"26","author":"Park","year":"2020","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/hep.21642","article-title":"Incidence of non-Hodgkin\u2019s lymphoma among individuals with chronic hepatitis B virus infection","volume":"46","author":"Quesenberry","year":"2007","journal-title":"Hepatology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1111\/jvh.13301","article-title":"Identification of hepatitis B virus aetiologic antigens, HBx and Pre-S2, in diffuse large B-cell lymphoma","volume":"27","author":"Huang","year":"2020","journal-title":"J. Viral Hepat."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1002\/ijc.33027","article-title":"Characterization of hepatitis B virus infection and viral DNA integration in non-Hodgkin lymphoma","volume":"147","author":"Li","year":"2020","journal-title":"Int. J. Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.canlet.2020.03.022","article-title":"Oncogenic HBV variants and integration are present in hepatic and lymphoid cells derived from chronic HBV patients","volume":"480","author":"Lau","year":"2020","journal-title":"Cancer Lett."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1136\/gutjnl-2013-306409","article-title":"Patients with chronic hepatitis B treated with oral antiviral therapy retain a higher risk for HCC compared with patients with inactive stage disease","volume":"63","author":"Cho","year":"2014","journal-title":"Gut"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.2147\/CMAR.S244381","article-title":"Clinical Analysis and Prognostic Significance of Hepatitis B Virus Infections with Diffuse Large B-Cell Lymphoma","volume":"12","author":"Kang","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1634\/theoncologist.2019-0756","article-title":"Hepatitis B Surface Antigen Positivity Is an Independent Unfavorable Prognostic Factor in Diffuse Large B-Cell Lymphoma in the Rituximab Era","volume":"25","author":"Cheng","year":"2020","journal-title":"Oncologist"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1182\/blood-2017-11-817601","article-title":"Genetic landscape of hepatitis B virus-associated diffuse large B-cell lymphoma","volume":"131","author":"Ren","year":"2018","journal-title":"Blood"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1001\/jamaoncol.2018.4070","article-title":"Risk of Hepatocellular Carcinoma in Patients Treated with Entecavir vs. Tenofovir for Chronic Hepatitis B: A Korean Nationwide Cohort Study","volume":"5","author":"Choi","year":"2019","journal-title":"JAMA Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jhep.2019.03.028","article-title":"A multicenter study of entecavir vs. tenofovir on prognosis of treatment-naive chronic hepatitis B in South Korea","volume":"71","author":"Kim","year":"2019","journal-title":"J. Hepatol."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/9\/1943\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:21:19Z","timestamp":1760142079000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/9\/1943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,31]]},"references-count":19,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["v14091943"],"URL":"https:\/\/doi.org\/10.3390\/v14091943","relation":{},"ISSN":["1999-4915"],"issn-type":[{"type":"electronic","value":"1999-4915"}],"subject":[],"published":{"date-parts":[[2022,8,31]]}}}