{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T09:48:02Z","timestamp":1793353682127,"version":"4.5.0"},"reference-count":52,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T00:00:00Z","timestamp":1662163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"General Research Fund of the Hong Kong Research Grants Council (RGC)","award":["16213121"],"award-info":[{"award-number":["16213121"]}]},{"name":"General Research Fund of the Hong Kong Research Grants Council (RGC)","award":["FT200100928"],"award-info":[{"award-number":["FT200100928"]}]},{"name":"Australian Government","award":["16213121"],"award-info":[{"award-number":["16213121"]}]},{"name":"Australian Government","award":["FT200100928"],"award-info":[{"award-number":["FT200100928"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Beginning in May 2022, a novel cluster of monkeypox virus infections was detected in humans. This virus has spread rapidly to non-endemic countries, sparking global concern. Specific vaccines based on the vaccinia virus (VACV) have demonstrated high efficacy against monkeypox viruses in the past and are considered an important outbreak control measure. Viruses observed in the current outbreak carry distinct genetic variations that have the potential to affect vaccine-induced immune recognition. Here, by investigating genetic variation with respect to orthologous immunogenic vaccinia-virus proteins, we report data that anticipates immune responses induced by VACV-based vaccines, including the currently available MVA-BN and ACAM2000 vaccines, to remain highly cross-reactive against the newly observed monkeypox viruses.<\/jats:p>","DOI":"10.3390\/v14091960","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T20:50:27Z","timestamp":1662670227000},"page":"1960","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Vaccinia-Virus-Based Vaccines Are Expected to Elicit Highly Cross-Reactive Immunity to the 2022 Monkeypox Virus"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6086-0307","authenticated-orcid":false,"given":"Syed Faraz","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Electrical and Electronic Engineering, University of Melbourne, Parkville, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9096-7634","authenticated-orcid":false,"given":"Muhammad Saqib","family":"Sohail","sequence":"additional","affiliation":[{"name":"Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5295-9067","authenticated-orcid":false,"given":"Ahmed Abdul","family":"Quadeer","sequence":"additional","affiliation":[{"name":"Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8086-2545","authenticated-orcid":false,"given":"Matthew R.","family":"McKay","sequence":"additional","affiliation":[{"name":"Department of Electrical and Electronic Engineering, University of Melbourne, Parkville, VIC 3010, Australia"},{"name":"Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.tim.2011.12.001","article-title":"Outbreaks of Human Monkeypox after Cessation of Smallpox Vaccination","volume":"20","author":"Reynolds","year":"2012","journal-title":"Trends Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0007791","article-title":"A Systematic Review of the Epidemiology of Human Monkeypox Outbreaks and Implications for Outbreak Strategy","volume":"13","author":"Beer","year":"2019","journal-title":"PLoS Negl. 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