{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:39:47Z","timestamp":1785152387932,"version":"3.55.0"},"reference-count":88,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Integral Health for Indigenous Peoples (PAI) of the Federal University of Vale do S\u00e3o Francisco-UNIVASF, Petrolina","award":["56304-917"],"award-info":[{"award-number":["56304-917"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Dengue fever, chikungunya, and zika are highly prevalent arboviruses transmitted by hematophagous arthropods, with a widely neglected impact in developing countries. These diseases cause acute illness in diverse populations, as well as potential cardiovascular complications. A systematic review was carried out to investigate the burden of cardiac involvement related to these arboviruses. Multiple databases were searched for articles that investigated the association of cardiovascular diseases with arboviruses, published up to March 2022. Relevant articles were selected and rated by two independent reviewers. Proportion meta-analysis was applied to assess the frequency-weighted mean of the cardiovascular findings. A total of 42 articles were selected (n = 76,678 individuals), with 17 manuscripts on dengue and 6 manuscripts on chikungunya undergoing meta-analysis. The global pooled incidence of cardiac events in dengue fever using a meta-analysis was 27.21% (95% CI 20.21\u201334.83; I2 = 94%). The higher incidence of dengue-related myocarditis was found in the population younger than 20 years old (33.85%; 95% CI 0.00\u201389.20; I2 = 99%). Considering the studies on chikungunya (n = 372), the global pooled incidence of cardiac involvement using a meta-analysis was 32.81% (95% CI 09.58\u201361.49, I2 = 96%). Two Zika studies were included that examined cases of infection by vertical transmission in Brazil, finding everything from structural changes to changes in heart rate variability that increase the risk of sudden death. In conclusion, cardiac involvement in arboviruses is not uncommon, especially in dengue fever.<\/jats:p>","DOI":"10.3390\/v14091988","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T20:50:27Z","timestamp":1662670227000},"page":"1988","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Heart Disease and Arboviruses: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9139-2414","authenticated-orcid":false,"given":"Jandir Mendon\u00e7a","family":"Nicacio","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Federal University of Vale do S\u00e3o Francisco\u2014UNIVASF, Petrolina 56304-917, PE, Brazil"},{"name":"Postgraduate Program in Human Ecology and Socio-Environmental Management, Bahia State University\u2014UNEB, Juazeiro 48904-711, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6324-7594","authenticated-orcid":false,"given":"Orlando Vieira","family":"Gomes","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Federal University of Vale do S\u00e3o Francisco\u2014UNIVASF, Petrolina 56304-917, PE, Brazil"},{"name":"Postgraduate Program in Human Ecology and Socio-Environmental Management, Bahia State University\u2014UNEB, Juazeiro 48904-711, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9601-6995","authenticated-orcid":false,"given":"Rodrigo Feliciano do","family":"Carmo","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Federal University of Vale do S\u00e3o Francisco\u2014UNIVASF, Petrolina 56304-917, PE, Brazil"},{"name":"Postgraduate Program in Applied Cellular and Molecular Biology, University of Pernambuco\u2014UPE, Recife 50100-010, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e1vio Luiz Pereira","family":"Nunes","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Applied Cellular and Molecular Biology, University of Pernambuco\u2014UPE, Recife 50100-010, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Roberto Coelho Ferreira","family":"Rocha","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Federal University of Vale do S\u00e3o Francisco\u2014UNIVASF, Petrolina 56304-917, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Dornels Freire de","family":"Souza","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Federal University of Vale do S\u00e3o Francisco\u2014UNIVASF, Petrolina 56304-917, PE, Brazil"},{"name":"Postgraduate Program in Human Ecology and Socio-Environmental Management, Bahia State University\u2014UNEB, Juazeiro 48904-711, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1846-6007","authenticated-orcid":false,"given":"Rafael Freitas de Oliveira","family":"Franca","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Foundation\/Fiocruz, Institute Aggeu Magalh\u00e3es, Recife 50740-465, PE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5664-4436","authenticated-orcid":false,"given":"Ricardo","family":"Khouri","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Foundation\/Fiocruz, Institute Gon\u00e7alo Moniz, Salvador 40296-710, BA, Brazil"},{"name":"Department of Medicine, Federal University of Bahia\u2014UFBA, Salvador 40110-909, BA, Brazil"},{"name":"Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5823-7903","authenticated-orcid":false,"given":"Manoel","family":"Barral-Netto","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Foundation\/Fiocruz, Institute Gon\u00e7alo Moniz, Salvador 40296-710, BA, Brazil"},{"name":"Department of Medicine, Federal University of Bahia\u2014UFBA, Salvador 40110-909, BA, Brazil"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Investiga\u00e7\u00e3o em Imunologia, University of S\u00e3o Paulo, S\u00e3o Paulo 05347-902, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson da Costa","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Federal University of Vale do S\u00e3o Francisco\u2014UNIVASF, Petrolina 56304-917, PE, Brazil"},{"name":"Postgraduate Program in Human Ecology and Socio-Environmental Management, Bahia State University\u2014UNEB, Juazeiro 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