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We describe disabilities present in children with CZS followed in a reference hospital in Rio de Janeiro, Brazil, based on the biopsychosocial model of the International Classification of Functioning, Disability and Health (ICF). This was a cohort study of children &gt;3 years of age with CZS. Disability was characterized through outcomes related to ICF components assessed via clinical and motor development evaluations. Among 50 children, with a median age of 40 months, 47 (94%) presented with severe impairment and 46 (92%) had microcephaly. Damage to the head and neck was found in most children, with abnormal central nervous system imaging universally present. Most children had cognitive impairment (92%), muscle tone problems (90%), and speech deficits (94%). We found movement limitations in all categories but more pervasively (80\u201394%), in postural transfers and displacements. The main environmental factors identified in the ICF model were the use of products or substances for personal consumption and access to health services. Children with CZS have extremely high rates of disability beyond aged 3 years, particularly regarding motor activity. ICF-based models can contribute to the assessment of health domains.<\/jats:p>","DOI":"10.3390\/v14102108","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T04:09:36Z","timestamp":1664424576000},"page":"2108","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Characterizing Disabilities in Preschool Aged Children with Congenital Zika Virus Syndrome with the ICF Model"],"prefix":"10.3390","volume":"14","author":[{"given":"Laura Cristina Machado Ribeiro","family":"de Souza","sequence":"first","affiliation":[{"name":"National Institute of Women, Children and Adolescents Health Fernandes Figueira, Oswaldo Cruz, Foundation (IFF-Fiocruz), Avenida Rui Barbosa, 716, Flamengo, Rio de Janeiro 22250-020, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2478-9144","authenticated-orcid":false,"given":"Carla Trevisan Martins","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"National Institute of Women, Children and Adolescents Health Fernandes Figueira, Oswaldo Cruz, Foundation (IFF-Fiocruz), Avenida Rui Barbosa, 716, Flamengo, Rio de Janeiro 22250-020, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3857-2787","authenticated-orcid":false,"given":"Tatiana","family":"Hamanaka","sequence":"additional","affiliation":[{"name":"National Institute of Women, Children and Adolescents Health Fernandes Figueira, Oswaldo Cruz, Foundation (IFF-Fiocruz), Avenida Rui Barbosa, 716, Flamengo, Rio de Janeiro 22250-020, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Castaneda","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Federal Institute of Rio de Janeiro (IFRJ), Rua Professor Carlos Wenceslau, 343-Realengo, Rio de Janeiro 21710-240, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nath\u00e1lia Crsitina Oliveira","family":"de Souza","sequence":"additional","affiliation":[{"name":"National Institute of Women, Children and Adolescents Health Fernandes Figueira, Oswaldo Cruz, Foundation (IFF-Fiocruz), Avenida Rui Barbosa, 716, Flamengo, Rio de Janeiro 22250-020, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6246-8915","authenticated-orcid":false,"given":"Sheila Moura","family":"Pone","sequence":"additional","affiliation":[{"name":"National Institute of Women, Children and Adolescents Health Fernandes Figueira, Oswaldo Cruz, Foundation (IFF-Fiocruz), Avenida Rui Barbosa, 716, Flamengo, Rio de Janeiro 22250-020, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1742-5211","authenticated-orcid":false,"given":"Karin","family":"Nielsen-Saines","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine, University of California, 10833 Le Conte Ave, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0280-2288","authenticated-orcid":false,"given":"Elizabeth B.","family":"Brickley","sequence":"additional","affiliation":[{"name":"London School of Hygiene & Tropical Medicine, Keppel St., London WC1E 7HT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2034-0294","authenticated-orcid":false,"given":"Maria Elisabeth Lopes","family":"Moreira","sequence":"additional","affiliation":[{"name":"National Institute of Women, Children and Adolescents Health Fernandes Figueira, Oswaldo Cruz, Foundation (IFF-Fiocruz), Avenida Rui Barbosa, 716, Flamengo, Rio de Janeiro 22250-020, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5152-2242","authenticated-orcid":false,"given":"Marcos Vinicius","family":"da Silva Pone","sequence":"additional","affiliation":[{"name":"National Institute of Women, Children and Adolescents Health Fernandes Figueira, Oswaldo Cruz, Foundation (IFF-Fiocruz), Avenida Rui Barbosa, 716, Flamengo, Rio de Janeiro 22250-020, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00381-017-3635-3","article-title":"Zika virus infection in children: Epidemiology and clinical manifestations","volume":"34","year":"2018","journal-title":"Childs Nerv. Syst. ChNS Off. J. Int. Soc. Pediatr. Neurosurg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jaapos.2018.07.352","article-title":"Visual function in infants with antenatal Zika virus exposure","volume":"22","author":"Zin","year":"2018","journal-title":"J. Am. Assoc. Pediatr. Ophthalmol. Strabismus."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ferreira, H.N.C., Schiariti, V., Regalado, I.C.R., Sousa, K.G., Pereira, S.A., Fechine, C.P.N.D.S., and Longo, E. (2018). Functioning and Disability Profile of Children with Microcephaly Associated with Congenital Zika Virus Infection. Int. J. Environ. Res. 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Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/jamapediatrics.2016.3982","article-title":"Characterizing the Pattern of Anomalies in Congenital Zika Syndrome for Pediatric Clinicians","volume":"171","author":"Moore","year":"2017","journal-title":"JAMA Pediatr."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Schiariti, V., Longo, E., Shoshmin, A., Kozhushko, L., Besstrashnova, Y., Kr\u00f3l, M., Neri Correia Campos, T., N\u00e1ryma Confessor Ferreira, H., Verissimo, C., and Shaba, D. (2018). Implementation of the International Classification of Functioning, Disability, and Health (ICF) Core Sets for Children and Youth with Cerebral Palsy: Global Initiatives Promoting Optimal Functioning. Int. J. Environ. Res. Public Health, 15.","DOI":"10.3390\/ijerph15091899"},{"key":"ref_8","unstructured":"Organiza\u00e7\u00e3o Mundial de Sa\u00fade (2015). CIF: Classifica\u00e7\u00e3o Internacional de Funcionalidade, Incapacidade e Sa\u00fade\/Centro Colaborador da OMS para a Fam\u00edlia de Classifica\u00e7\u00f5es Internacionais em Portugu\u00eas, Organiza\u00e7\u00e3o Panamericana de Sa\u00fade; Organiza\u00e7\u00e3o Mundial de Sa\u00fade."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e11518","DOI":"10.1590\/1982-0216\/202022111518","article-title":"Applicability of the ICF-CY in evaluating children with disabilities and family support: An integrative literature review","volume":"22","author":"Castro","year":"2020","journal-title":"Rev. CEFAC"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e038228","DOI":"10.1136\/bmjopen-2020-038228","article-title":"How congenital Zika virus impacted my child\u2019s functioning and disability: A Brazilian qualitative study guided by the ICF","volume":"10","author":"Campos","year":"2020","journal-title":"BMJ Open"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/PEP.0000000000000647","article-title":"Zika Virus After Emergency Response: Can the ICF Guide Rehabilitation of Children With Microcephaly?","volume":"31","author":"Longo","year":"2019","journal-title":"Pediatr. Phys. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.11606\/issn.2317-0190.v27i4a176351","article-title":"Liga\u00e7\u00e3o de um instrumento de avalia\u00e7\u00e3o cl\u00ednica de exposi\u00e7\u00e3o ao v\u00edrus Zika com a Classifica\u00e7\u00e3o Internacional de Funcionalidade, Incapacidade e Sa\u00fade","volume":"27","author":"Cabral","year":"2020","journal-title":"Acta Fisi\u00e1trica"},{"key":"ref_13","unstructured":"Pereira, N., Carrapatoso, B., Moreira, B., de Souza, N.C.O., Van Eyken, E., and Castaneda, L. (2020). Avalia\u00e7\u00e3o da atividade na s\u00edndrome cong\u00eanita do Zika Virus. In: Luciana castaneda Ribeiro e Shamir Sulyvan ORG. Classifica\u00e7\u00e3o Internacional DE Funcionalidade, Incapacidade E Sa\u00fade (CIF): Experi\u00eancias Acad\u00eamicas no Brasil, EDITORA CRV. [1st ed.]."},{"key":"ref_14","unstructured":"Russell, D., Wright, M., Rosenbaum, P.L., and Avery, L.M. (2013). GMFM (GMFM-66 & GMFM-88) User\u2019s Manual, Wiley. [2nd ed.]."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1056\/NEJMra1808246","article-title":"Zika Virus Infection\u2014After the Pandemic. Longo, D.L., organizador","volume":"381","author":"Musso","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1177\/0883073819885724","article-title":"Cerebral Palsy in Children With Congenital Zika Syndrome: A 2-Year Neurodevelopmental Follow-up","volume":"35","author":"Carvalho","year":"2020","journal-title":"J. Child. Neurol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Fran\u00e7a, T.L.B.D., Medeiros, W.R., Souza, N.L.D., Longo, E., Pereira, S.A., Fran\u00e7a, T.B.D.O., and Sousa, K.G. (2018). Growth and Development of Children with Microcephaly Associated with Congenital Zika Virus Syndrome in Brazil. Int. J. Environ. Res. Public Health, 15.","DOI":"10.3390\/ijerph15091990"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/dmcn.14227","article-title":"Motor function in children with congenital Zika syndrome","volume":"62","author":"Melo","year":"2020","journal-title":"Dev. Med. Child. Neurol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/DBP.0000000000000722","article-title":"Early Gross Motor Development Among Brazilian Children with Microcephaly Born Right After Zika Virus Infection Outbreak","volume":"41","author":"Ventura","year":"2020","journal-title":"J. Dev. Behav. Pediatr."},{"key":"ref_20","first-page":"1","article-title":"A participa\u00e7\u00e3o de crian\u00e7as com a S\u00edndrome Cong\u00eanita do Zika V\u00edrus: Intercess\u00f5es entre o modelo bioecol\u00f3gico e a funcionalidade humana","volume":"16","author":"Pletsch","year":"2021","journal-title":"Prax Educ."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"i1901","DOI":"10.1136\/bmj.i1901","article-title":"Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: Retrospective case series study","volume":"353","author":"Aragao","year":"2016","journal-title":"BMJ"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jaapos.2017.05.024","article-title":"The visual system in infants with microcephaly related to presumed congenital Zika syndrome","volume":"21","author":"Carneiro","year":"2017","journal-title":"J. Am. Assoc. Pediatr. Ophthalmol. Strabismus"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e20181104","DOI":"10.1542\/peds.2018-1104","article-title":"Eye Findings in Infants With Suspected or Confirmed Antenatal Zika Virus Exposure","volume":"142","author":"Tsui","year":"2018","journal-title":"Pediatrics"},{"key":"ref_24","first-page":"i3899","article-title":"Congenital Zika syndrome with arthrogryposis: Retrospective case series study","volume":"354","author":"Lins","year":"2016","journal-title":"BMJ"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Costa Monteiro, L.M., Cruz, G.N.D.O., Fontes, J.M., Saad Salles, T.R.D., Boechat, M.C.B., Monteiro, A.C., and Moreira, M.E.L. (2018). Neurogenic bladder findings in patients with Congenital Zika Syndrome: A novel condition. Damaser M, organizador. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0193514"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e021304","DOI":"10.1136\/bmjopen-2017-021304","article-title":"Neurodevelopment of 24 children born in Brazil with congenital Zika syndrome in 2015: A case series study","volume":"8","author":"Alves","year":"2018","journal-title":"BMJ Open"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"49981","DOI":"10.34117\/bjdv6n7-593","article-title":"Desmame ventilat\u00f3rio complexo em uma crian\u00e7a pneumopata cr\u00f4nica com s\u00edndrome cong\u00eanita do Zika V\u00edrus","volume":"6","author":"Fleming","year":"2020","journal-title":"Braz. J. Dev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1056\/NEJMoa2101195","article-title":"Mortality from Congenital Zika Syndrome\u2014Nationwide Cohort Study in Brazil","volume":"386","author":"Paixao","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1055\/s-0040-1718919","article-title":"Gross Motor Function in Children with Congenital Zika Syndrome","volume":"52","author":"Takahasi","year":"2021","journal-title":"Neuropediatrics"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Longo, E., Campos, A.C.D., and Barreto, A.S. (2020). Go Zika Go: A Feasibility Protocol of a Modified Ride-on Car Intervention for Children with Congenital Zika Syndrome in Brazil. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17186875"}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/10\/2108\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:38:22Z","timestamp":1760143102000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/10\/2108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,23]]},"references-count":30,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["v14102108"],"URL":"https:\/\/doi.org\/10.3390\/v14102108","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,23]]}}}