{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:12:16Z","timestamp":1789431136335,"version":"build-2803163510"},"reference-count":166,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T00:00:00Z","timestamp":1664928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo (FAPESP)","doi-asserted-by":"publisher","award":["2020\/03639-6"],"award-info":[{"award-number":["2020\/03639-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo (FAPESP)","doi-asserted-by":"publisher","award":["2020\/08615-8"],"award-info":[{"award-number":["2020\/08615-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo (FAPESP)","doi-asserted-by":"publisher","award":["309940\/2019-2"],"award-info":[{"award-number":["309940\/2019-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","doi-asserted-by":"publisher","award":["2020\/03639-6"],"award-info":[{"award-number":["2020\/03639-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","doi-asserted-by":"publisher","award":["2020\/08615-8"],"award-info":[{"award-number":["2020\/08615-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","doi-asserted-by":"publisher","award":["309940\/2019-2"],"award-info":[{"award-number":["309940\/2019-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior-Brasil (CAPES)","award":["2020\/03639-6"],"award-info":[{"award-number":["2020\/03639-6"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior-Brasil (CAPES)","award":["2020\/08615-8"],"award-info":[{"award-number":["2020\/08615-8"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior-Brasil (CAPES)","award":["309940\/2019-2"],"award-info":[{"award-number":["309940\/2019-2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Since the intricate and complex steps in pathogenesis and host-viral interactions of arthropod-borne viruses or arboviruses are not completely understood, the multi-omics approaches, which encompass proteomics, transcriptomics, genomics and metabolomics network analysis, are of great importance. We have reviewed the omics studies on mosquito-borne viruses of the Togaviridae, Peribuyaviridae and Phenuiviridae families, specifically for Chikungunya, Mayaro, Oropouche and Rift Valley Fever viruses. Omics studies can potentially provide a new perspective on the pathophysiology of arboviruses, contributing to a better comprehension of these diseases and their effects and, hence, provide novel insights for the development of new antiviral drugs or therapies.<\/jats:p>","DOI":"10.3390\/v14102194","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T02:10:27Z","timestamp":1665540627000},"page":"2194","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A Review of Omics Studies on Arboviruses: Alphavirus, Orthobunyavirus and Phlebovirus"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5850-6360","authenticated-orcid":false,"given":"Rafaela dos S.","family":"Peinado","sequence":"first","affiliation":[{"name":"Multiuser Center for Biomolecular Innovation, Department of Physics, Sao Paulo State University, Sao Jose do Rio Preto 15054-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8763-3884","authenticated-orcid":false,"given":"Raphael J.","family":"Eberle","sequence":"additional","affiliation":[{"name":"Institute of Biological Information Processing, IBI-7: Structural Biochemistry, Forschungszentrum J\u00fclich, 52425 J\u00fclich, Germany"},{"name":"Institut f\u00fcr Physikalische Biologie, Heinrich-Heine-Universit\u00e4t, 40225 D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2460-1145","authenticated-orcid":false,"given":"Raghuvir K.","family":"Arni","sequence":"additional","affiliation":[{"name":"Multiuser Center for Biomolecular Innovation, Department of Physics, Sao Paulo State University, Sao Jose do Rio Preto 15054-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6518-6497","authenticated-orcid":false,"given":"M\u00f4nika A.","family":"Coronado","sequence":"additional","affiliation":[{"name":"Institute of Biological Information Processing, IBI-7: Structural Biochemistry, Forschungszentrum J\u00fclich, 52425 J\u00fclich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-981-10-8727-1_1","article-title":"Arboviruses: A Family on the Move","volume":"1062","author":"Young","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/s41590-018-0210-3","article-title":"The immune response against flaviviruses","volume":"19","author":"Mongkolsapaya","year":"2018","journal-title":"Nat. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.coviro.2019.01.001","article-title":"Emergence and re-emergence of mosquito-borne arboviruses","volume":"34","author":"Huang","year":"2019","journal-title":"Curr. Opin. Virol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13059-017-1215-1","article-title":"Multi-omics approaches to disease","volume":"18","author":"Hasin","year":"2017","journal-title":"Genome Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev.genom.9.081307.164359","article-title":"Next-Generation DNA Sequencing Methods","volume":"9","author":"Mardis","year":"2008","journal-title":"Annu. Rev. Genom. Hum. Genet."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrg2484","article-title":"RNA-Seq: A revolutionary tool for transcriptomics","volume":"10","author":"Wang","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e8126","DOI":"10.15252\/msb.20178126","article-title":"Data-independent acquisition-based SWATH\u2014MS for quantitative proteomics: A tutorial","volume":"14","author":"Ludwig","year":"2018","journal-title":"Mol. Syst. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1146\/annurev-anchem-071213-020216","article-title":"High-Throughput Proteomics","volume":"7","author":"Zhang","year":"2014","journal-title":"Annu. Rev. Anal. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Emwas, A.-H., Roy, R., McKay, R.T., Tenori, L., Saccenti, E., Gowda, G.A.N., Raftery, D., Alahmari, F., Jaremko, L., and Jaremko, M. (2019). NMR Spectroscopy for Metabolomics Research. Metabolites, 9.","DOI":"10.3390\/metabo9070123"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/mas.20108","article-title":"Mass Spectrometry-based metabolomics","volume":"26","author":"Dettmer","year":"2007","journal-title":"Mass. Spectrom. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Pinu, F.R., Beale, D.J., Paten, A.M., Kouremenos, K., Swarup, S., Schirra, H.J., and Wishart, D. (2019). Systems Biology and Multi-Omics Integration: Viewpoints from the Metabolomics Research Community. Metabolites, 9.","DOI":"10.3390\/metabo9040076"},{"key":"ref_12","first-page":"55","article-title":"Caracter\u00edsticas gerais e epidemiologia dos arbov\u00edrus emergentes no Brasil","volume":"5","author":"Lopes","year":"2014","journal-title":"Rev. Pan-Amaz. Sa\u00fade"},{"key":"ref_13","unstructured":"Santos, N.S.O., Romanos, M.T.V., and Wigg, M.D. (2008). Introdu\u00e7\u00e3o \u00e0 Virologia Humana, Guanabara Koogan, Campo Grande. [2nd ed.]."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1099\/jgv.0.001072","article-title":"ICTV Report Consortium ICTV Virus Taxonomy Profile: Togaviridae","volume":"99","author":"Chen","year":"2018","journal-title":"J. Gen. Virol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0092-8674(95)90516-2","article-title":"Nucleocapsid and glycoprotein organization in an enveloped virus","volume":"80","author":"Cheng","year":"1995","journal-title":"Cell"},{"key":"ref_16","first-page":"651","article-title":"Alphaviruses","volume":"Volume 1","author":"Knipe","year":"2013","journal-title":"Fields Virology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1128\/jvi.17.1.149-159.1976","article-title":"5\u2019 nucleotide sequence of sindbis viral RNA","volume":"17","author":"Hefti","year":"1976","journal-title":"J. Virol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.virusres.2005.11.006","article-title":"Mayaro virus: Complete nucleotide sequence and phylogenetic relationships with other alphaviruses","volume":"117","author":"Lavergne","year":"2006","journal-title":"Virus Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1099\/jgv.0.000249","article-title":"Alphavirus RNA synthesis and non-structural protein functions","volume":"96","author":"Rupp","year":"2015","journal-title":"J. Gen. Virol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.virusres.2015.01.016","article-title":"The 5\u2032 and 3\u2032 ends of alphavirus RNAs\u2014Non-coding is not non-functional","volume":"206","author":"Hyde","year":"2015","journal-title":"Virus Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1128\/jvi.61.5.1301-1309.1987","article-title":"Processing of the Semliki Forest virus structural polyprotein: Role of the capsid protease","volume":"61","author":"Melancon","year":"1987","journal-title":"J. Virol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.2217\/fvl.15.76","article-title":"Mayaro virus: A neglected arbovirus of the Americas","volume":"10","author":"Mota","year":"2015","journal-title":"Futur. Virol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0042-6822(88)90141-9","article-title":"Semliki forest virus particles containing only the E1 envelope glycoprotein are infectious and can induce cell-cell fusion","volume":"166","author":"Omar","year":"1988","journal-title":"Virology"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"G\u00f6tte, B., Liu, L., and McInerney, G.M. (2018). The enigmatic alphavirus non-structural protein 3 (nsP3) revealing its secrets at last. Viruses, 10.","DOI":"10.3390\/v10030105"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1002\/jmv.23403","article-title":"Identification of prohibitin as a Chikungunya virus receptor protein","volume":"84","author":"Wintachai","year":"2012","journal-title":"J. Med. Virol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"8327","DOI":"10.1128\/JVI.01025-13","article-title":"Role of the Phosphatidylserine Receptor TIM-1 in Enveloped-Virus Entry","volume":"87","author":"Kondratowicz","year":"2013","journal-title":"J. Virol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1128\/JVI.03116-13","article-title":"A Single-Amino-Acid Polymorphism in Chikungunya Virus E2 Glycoprotein Influences Glycosaminoglycan Utilization","volume":"88","author":"Silva","year":"2014","journal-title":"J. Virol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.3390\/v7072792","article-title":"Early events in chikungunya virus infec-tion\u2014From virus cell binding to membrane fusion","volume":"7","author":"Hoornweg","year":"2015","journal-title":"Viruses"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1016\/S1473-3099(16)30385-1","article-title":"Chikungunya virus: An update on the biology and pathogenesis of this emerging pathogen","volume":"17","author":"Burt","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.1073\/pnas.80.17.5271","article-title":"Sequence coding for the alphavirus nonstructural proteins is interrupted by an opal termination codon","volume":"80","author":"Strauss","year":"1983","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1128\/jvi.68.3.1874-1885.1994","article-title":"Regulation of Sindbis virus RNA replication: Uncleaved P123 and nsP4 function in minus-strand RNA synthesis, whereas cleaved products from P123 are required for efficient plus-strand RNA synthesis","volume":"68","author":"Shirako","year":"1994","journal-title":"J. Virol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.virusres.2004.08.008","article-title":"Budding of alphaviruses","volume":"106","author":"Garoff","year":"2004","journal-title":"Virus Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1002\/j.1460-2075.1994.tb06587.x","article-title":"Polypeptide requirements for assembly of functional Sindbis virus replication complexes: A model for the temporal regulation of minus- and plus-strand RNA synthesis","volume":"13","author":"Lemm","year":"1994","journal-title":"EMBO J."},{"key":"ref_34","unstructured":"Baron, S. (1996). Alphaviruses (togaviridae) and flaviviruses (Flaviviridae). Medical Microbiology, University of Texas Medical Branch at Galveston. [4th ed.]."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1128\/mr.58.3.491-562.1994","article-title":"The alphaviruses: Gene expression, replication, and evolution","volume":"58","author":"Strauss","year":"1994","journal-title":"Microbiol. Rev."},{"key":"ref_36","first-page":"973516","article-title":"Molecular mechanisms involved in the pathogenesis of alpha-virus-induced arthritis","volume":"2013","year":"2013","journal-title":"Biomed Res. Int."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Dupuis-Maguiraga, L., Noret, M., Brun, S., Le Grand, R., Gras, G., and Roques, P. (2012). Chikungunya Disease: Infection-Associated Markers from the Acute to the Chronic Phase of Arbovirus-Induced Arthralgia. PLOS Negl. Trop. Dis., 6.","DOI":"10.1371\/journal.pntd.0001446"},{"key":"ref_38","first-page":"601","article-title":"Characterization of Ross River Virus Tropism and Virus-Induced Inflammation in a Mouse Model of Viral Arthritis and Myositis","volume":"52","author":"Morrison","year":"2006","journal-title":"J. Virol."},{"key":"ref_39","first-page":"31","article-title":"Membrane binding and rearrangement by chikungunya virus capping enzyme nsP1","volume":"544","author":"Gottipati","year":"2020","journal-title":"Physiol. Behav."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"10265","DOI":"10.1128\/JVI.72.12.10265-10269.1998","article-title":"Alphavirus Replicase Protein NSP1 Induces Filopodia and Rear-rangement of Actin Filaments","volume":"72","author":"Laakkonen","year":"1998","journal-title":"J. Virol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e00196","DOI":"10.1042\/BSR20150086","article-title":"Full length and protease domain activity of chikungunya virus nsP2 differ from other alphavirus nsP2 proteases in recognition of small peptide substrates","volume":"35","author":"Saisawang","year":"2015","journal-title":"Biosci. Rep."},{"key":"ref_42","first-page":"369","article-title":"Nuclear targeting of Semliki Forest virus nsP2","volume":"9","author":"Rikkonen","year":"1994","journal-title":"Arch. Virol. Suplemmenta"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"5686","DOI":"10.1128\/JVI.02739-05","article-title":"Sindbis Virus Nonstructural Protein nsP2 Is Cytotoxic and Inhibits Cellular Transcription","volume":"80","author":"Garmashova","year":"2006","journal-title":"J. Virol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.4014\/jmb.1910.10014","article-title":"Chikungunya virus-encoded NSP2, E2 and E1 strongly antagonize the interferon-\u03b2 signaling pathway","volume":"29","author":"Bae","year":"2019","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.virol.2009.03.031","article-title":"The nsP3 macro domain is important for Sindbis virus replication in neurons and neurovirulence in mice","volume":"388","author":"Park","year":"2009","journal-title":"Virology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"8493","DOI":"10.1128\/JVI.00713-06","article-title":"Structural and Functional Basis for ADP-Ribose and Poly(ADP-Ribose) Binding by Viral Macro Domains","volume":"80","author":"Egloff","year":"2006","journal-title":"J. Virol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"6534","DOI":"10.1128\/JVI.00189-09","article-title":"The Crystal Structures of Chikungunya and Venezuelan Equine Encephalitis Virus nsP3 Macro Domains Define a Conserved Adenosine Binding Pocket","volume":"83","author":"Malet","year":"2009","journal-title":"J. Virol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1006\/viro.1996.0254","article-title":"Complete sequence of Venezuelan equine encephalitis virus subtype IE reveals con-served and hypervariable domains within the C terminus of nsP3","volume":"219","author":"Oberste","year":"1996","journal-title":"Virology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"16534","DOI":"10.1073\/pnas.1210418109","article-title":"Structural and functional insights into alphavirus polyprotein processing and pathogenesis","volume":"109","author":"Shin","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1128\/JVI.03612-14","article-title":"Stress Granule Components G3BP1 and G3BP2 Play a Proviral Role Early in Chikungunya Virus Replication","volume":"89","author":"Scholte","year":"2015","journal-title":"J. Virol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1099\/vir.0.18936-0","article-title":"Amino acid mutations in the replicase protein nsP3 of Semliki Forest virus cumulatively affect neurovirulence","volume":"84","author":"Tuittila","year":"2003","journal-title":"J. Gen. Virol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1099\/jgv.0.000467","article-title":"Molecular determinants of alphavirus neuropathogenesis in mice","volume":"97","author":"Atkins","year":"2016","journal-title":"J. Gen. Virol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.virusres.2017.01.007","article-title":"Alphavirus polymerase and RNA replication","volume":"234","author":"Ahola","year":"2017","journal-title":"Virus Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"8967","DOI":"10.1073\/pnas.88.20.8967","article-title":"Sindbis virus RNA polymerase is degraded by the N-end rule pathway","volume":"88","author":"Kuhn","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"9962","DOI":"10.1128\/JVI.01067-06","article-title":"Catalytic Core of Alphavirus Nonstructural Protein nsP4 Possesses Terminal Adenylyltransferase Activity","volume":"80","author":"Tomar","year":"2006","journal-title":"J. Virol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"JVI0035521","DOI":"10.1128\/JVI.00355-21","article-title":"nsP4 Is a Major Determinant of Alphavirus Replicase Activity and Template Selectivity","volume":"95","author":"Lello","year":"2021","journal-title":"J. Virol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0079-6603(02)71044-1","article-title":"Functions of alphavirus nonstructural proteins in RNA replication","volume":"71","author":"Ahola","year":"2002","journal-title":"Prog. Nucleic Acid Res. Mol. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11262-018-1611-y","article-title":"Molecular aspects of Rift Valley fever virus and the emergence of reassortants","volume":"55","author":"Gaudreault","year":"2019","journal-title":"Virus Genes"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.3390\/v6114373","article-title":"Bunyavirus-Vector Interactions","volume":"6","author":"Horne","year":"2014","journal-title":"Viruses"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1099\/vir.0.035105-0","article-title":"Recent advances in the molecular and cellular biology of bunyaviruses","volume":"92","author":"Walter","year":"2011","journal-title":"J. Gen. Virol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Sakkas, H., Bozidis, P., Franks, A., and Papadopoulou, C. (2018). Oropouche Fever: A Review. Viruses, 10.","DOI":"10.3390\/v10040175"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.micinf.2017.11.013","article-title":"Oropouche fever, an emergent disease from the Americas","volume":"20","author":"Escobar","year":"2018","journal-title":"Microbes Infect."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.4269\/ajtmh.16-0672","article-title":"Oropouche Virus: Clinical, Epidemiological, and Molecular Aspects of a Neglected Orthobunyavirus","volume":"96","author":"Figueiredo","year":"2017","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.meegid.2019.04.030","article-title":"Genomic characterization of orthobunyavirus of veterinary importance in America","volume":"73","author":"Tauro","year":"2019","journal-title":"Infect. Genet. Evol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.virusres.2017.01.018","article-title":"Transcription and replication mechanisms of Bunyaviridae and Are-naviridae L proteins","volume":"234","author":"Ferron","year":"2017","journal-title":"Virus Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1099\/vir.0.024240-0","article-title":"Amino acid changes within the Bunyamwera virus nucleocapsid protein differentially affect the mRNA transcription and RNA replication activities of assembled ribonucleoprotein templates","volume":"92","author":"Walter","year":"2011","journal-title":"J. Gen. Virol."},{"key":"ref_67","first-page":"1244","article-title":"Bunyaviridae","volume":"Volume 1","author":"Knipe","year":"2013","journal-title":"Fields Virology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1743-422X-5-82","article-title":"Rift Valley fever virus structural proteins: Expression, characterization and assembly of re-combinant proteins","volume":"5","author":"Liu","year":"2008","journal-title":"Virol. J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.virol.2006.09.035","article-title":"The NSm proteins of Rift Valley fever virus are dispensable for matu-ration, replication and infection","volume":"359","author":"Gerrard","year":"2007","journal-title":"Virology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"9798","DOI":"10.1128\/JVI.78.18.9798-9806.2004","article-title":"NSs Protein of Rift Valley Fever Virus Blocks Interferon Production by Inhibiting Host Gene Transcription","volume":"78","author":"Billecocq","year":"2004","journal-title":"J. Virol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1051\/vetres\/2010033","article-title":"Rift Valley fever virus (Bunyaviridae: Phlebovirus): An update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention","volume":"41","author":"Pepin","year":"2010","journal-title":"Vet. Res."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Rossmann, M.G., and Rao, V.B. (2012). Bunyavirus: Structure and Replication. Advances in Experimental Medicine and Biology: Viral Molecular Machines, Springer.","DOI":"10.1007\/978-1-4614-0980-9"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1111\/j.1462-5822.2008.01184.x","article-title":"The unique architecture of Bunyamwera virus factories around the Golgi complex","volume":"10","author":"Fontana","year":"2012","journal-title":"Cell. Microbiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3390\/v3050493","article-title":"The Pathogenesis of Rift Valley Fever","volume":"3","author":"Ikegami","year":"2011","journal-title":"Viruses"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/0035-9203(55)90080-8","article-title":"An epidemic of virus disease in Southern Province, Tanganyika territory, in 1952\u20131953","volume":"49","author":"Robinson","year":"1955","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1086\/605496","article-title":"Chikungunya Fever: An Epidemiological Review of a Re-Emerging Infectious Disease","volume":"49","author":"Staples","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nrmicro2368","article-title":"Biology and pathogenesis of chikungunya virus","volume":"8","author":"Schwartz","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.cll.2017.01.008","article-title":"Chikungunya virus","volume":"37","author":"Vu","year":"2017","journal-title":"Clin. Lab. Med."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Filomatori, C.V., Bardossy, E.S., Merwaiss, F., Suzuki, Y., Henrion, A., Saleh, M.C., and Alvarez, D.E. (2019). RNA recombination at Chikungunya virus 3\u2019UTR as an evolutionary mechanism that provides adaptability. PLOS Pathog., 15.","DOI":"10.1371\/journal.ppat.1007706"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Schneider, A.D.B., Ochsenreiter, R., Hostager, R., Hofacker, I.L., Janies, D., and Wolfinger, M.T. (2019). Updated Phylogeny of Chikungunya Virus Suggests Lineage-Specific RNA Architecture. Viruses, 11.","DOI":"10.3390\/v11090798"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.immuni.2007.08.012","article-title":"Innate recognition of viruses","volume":"27","author":"Pichlmair","year":"2007","journal-title":"Immunity"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-065X.2008.00726.x","article-title":"Viral sensors: Diversity in pathogen recognition","volume":"227","author":"McCartney","year":"2009","journal-title":"Immunol. Rev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"5903","DOI":"10.4049\/jimmunol.0904181","article-title":"Active Infection of Human Blood Monocytes by Chikungunya Virus Triggers an Innate Immune Response","volume":"184","author":"Her","year":"2010","journal-title":"J. Immunol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"7180","DOI":"10.1128\/JVI.00541-12","article-title":"Evasion of the Innate Immune Response: The Old World Alphavirus nsP2 Protein Induces Rapid Degradation of Rpb1, a Catalytic Subunit of RNA Polymerase II","volume":"86","author":"Akhrymuk","year":"2012","journal-title":"J. Virol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Sourisseau, M., Schilte, C., Casartelli, N., Trouillet, C., Guivel-Benhassine, F., Rudnicka, D., Sol-Foulon, N., Roux, K.L., Prevost, M.C., and Fisihi, H. (2007). Char-acterization of reemerging chikungunya virus. PLoS Pathog., 3.","DOI":"10.1371\/journal.ppat.0030089"},{"key":"ref_86","first-page":"211","article-title":"Chikungunya virus infection: An overview","volume":"36","author":"Caglioti","year":"2013","journal-title":"New Microbiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1038\/s41467-022-31835-x","article-title":"CHIKV infection repro-grams codon optimality to favor viral RNA translation by altering the tRNA epitranscriptome","volume":"13","author":"Jungfleisch","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Levi, L.I., Rezelj, V.V., Henrion-Lacritick, A., Erazo, D., Boussier, J., Vallet, T., Bernhauerov\u00e1, V., Suzuki, Y., Carrau, L., and Weger-Lucarelli, J. (2021). Defective viral genomes from chikungunya virus are broad-spectrum antivirals and prevent virus dissemination in mosquitoes. PLOS Pathog., 17.","DOI":"10.1371\/journal.ppat.1009110"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"104411","DOI":"10.1016\/j.cellimm.2021.104411","article-title":"Interleukin 27 as an inducer of antiviral response against chikungunya virus infection in human macrophages","volume":"367","author":"Fernandez","year":"2021","journal-title":"Cell. Immunol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1002\/pmic.201000500","article-title":"Differential proteome analysis of Chikungunya virus- infected new-born mice tissues reveal implication of stress, inflammatory and apoptotic pathways in disease pathogenesis","volume":"11","author":"Dhanwani","year":"2011","journal-title":"Proteomics"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Thio, C.L., Yusof, R., Abdul-rahman, P.S.A., and Karsani, A. (2013). Differential Proteome Analysis of Chikungunya Virus Infection on Host Cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0061444"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1002\/pmic.201400581","article-title":"Temporal SILAC-based quantitative proteomics identifies host factors involved in chikungunya virus replication","volume":"15","author":"Treffers","year":"2015","journal-title":"Proteomics"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jprot.2014.06.003","article-title":"Proteomic profiling of chikungunya virus-infected human muscle cells: Reveal the role of cytoskeleton network in CHIKV replication","volume":"108","author":"Issac","year":"2014","journal-title":"J. Proteom."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1021\/acs.jproteome.0c00173","article-title":"Quantitative Proteomic Analysis of Chikungunya Virus-Infected Aedes aegypti Reveals Proteome Modulations Indicative of Persistent Infection","volume":"19","author":"Cui","year":"2020","journal-title":"J. Proteome Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"23696","DOI":"10.1038\/s41598-021-03211-0","article-title":"High resolution proteomics of Aedes aegypti salivary glands infected with either dengue, Zika or chikungunya viruses identify new virus specific and broad antiviral factors","volume":"11","author":"Chowdhury","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"920425","DOI":"10.3389\/fcimb.2022.920425","article-title":"Aedes aegypti Aag-2 Cell Proteome Modulation in Response to Chikungunya Virus Infection","volume":"12","author":"Vasconcellos","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/1348-0421.12793","article-title":"Proteomic analysis of CHIKV-infected human fibro-blast-like synoviocytes: Identification of host factors potentially associated with CHIKV replication and cellular pathogenesis","volume":"64","author":"Sukkaew","year":"2020","journal-title":"Microbiol. Immunol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.3389\/fmicb.2017.01556","article-title":"Transcriptomic Analyses Reveal Differential Gene Expression of Immune and Cell Death Pathways in the Brains of Mice Infected with West Nile Virus and Chikungunya Virus","volume":"8","author":"Lim","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Zhao, L., Alto, B.W., Jiang, Y., Yu, F., and Zhang, Y. (2019). Transcriptomic Analysis of Aedes aegypti Innate Immune System in Response to Ingestion of Chikungunya Virus. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133133"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1365-2583.2011.01078.x","article-title":"A role for endosomal proteins in alphavirus dissemination in mosquitoes","volume":"20","author":"Campbell","year":"2011","journal-title":"Insect Mol. Biol."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Liu, Y., Zhang, F., Liu, J., Xiao, X., Zhang, S., Qin, C., Xiang, Y., Wang, P., and Cheng, G. (2014). Transmission-Blocking Antibodies against Mosquito C-Type Lectins for Dengue Prevention. PLOS Pathog., 10.","DOI":"10.1371\/journal.ppat.1003931"},{"key":"ref_102","first-page":"467","article-title":"Infection pattern and transmission potential of chikungunya virus in two New World laboratory-adapted Aedes aegypti strains","volume":"41","author":"Dong","year":"2004","journal-title":"Sci. Rep."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1603\/0022-2585-41.3.467","article-title":"Evidence for arbovirus dissemination conduits from the mosquito (Diptera: Culicidae) midgut","volume":"41","author":"Romoser","year":"2004","journal-title":"J. Med. Entomol."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Dong, S., Behura, S.K., and Franz, A.W.E. (2017). The midgut transcriptome of Aedes aegypti fed with saline or protein meals containing chikungunya virus reveals genes potentially involved in viral midgut escape. BMC Genom., 18.","DOI":"10.1186\/s12864-017-3775-6"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Vedururu, R.K., Neave, M.J., Tachedjian, M., Klein, M.J., Gorry, P.R., Duchemin, J.-B., and Paradkar, P.N. (2019). RNASeq Analysis of Aedes albopictus Mosquito Midguts after Chikungunya Virus Infection. Viruses, 11.","DOI":"10.3390\/v11060513"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Vedururu, R.K., Neave, M.J., Sundaramoorthy, V., Green, D., Harper, J.A., Gorry, P.R., Duchemin, J.-B., and Paradkar, P.N. (2019). Whole Transcriptome Analysis of Aedes albopictus Mosquito Head and Thorax Post-Chikungunya Virus Infection. Pathogens, 8.","DOI":"10.3390\/pathogens8030132"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Byers, N.M., Fleshman, A.C., Perera, R., and Molins, C.R. (2019). Metabolomic insights into human arboviral infections: Dengue, chikungunya, and zika viruses. Viruses, 11.","DOI":"10.3390\/v11030225"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"36833","DOI":"10.1038\/srep36833","article-title":"Serum metabolomics analysis of patients with chikungunya and dengue mono\/co-infections reveals distinct metabolite signatures in the three disease conditions","volume":"6","author":"Shrinet","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_109","first-page":"1","article-title":"Mayaro virus disease","volume":"1","author":"Pego","year":"2014","journal-title":"J. Hum. Virol. Retrovirology"},{"key":"ref_110","first-page":"163","article-title":"Mayaro: An emerging viral threat?","volume":"7","author":"Monsalve","year":"2018","journal-title":"Emerg. Microbes Infect."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"101462","DOI":"10.1016\/j.tmaid.2019.07.018","article-title":"Mayaro virus, a regional or global threat?","volume":"32","author":"Sun","year":"2019","journal-title":"Travel Med. Infect. Dis."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"8718","DOI":"10.1038\/s41598-017-07152-5","article-title":"Emergence of recombinant Mayaro virus strains from the Amazon basin","volume":"7","author":"Mavian","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1373\/clinchem.2005.061408","article-title":"Biomarkers of Oxidative Damage in Human Disease","volume":"52","author":"Rossi","year":"2006","journal-title":"Clin. Chem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virusres.2017.04.017","article-title":"Oxidative stress in Mayaro virus infection","volume":"236","author":"Camini","year":"2017","journal-title":"Virus Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"15289","DOI":"10.1038\/s41598-019-51713-9","article-title":"Mayaro Virus Induction of Oxidative Stress is Associated With Liver Pathology in a Non-Lethal Mouse Model","volume":"9","author":"Caetano","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e06396","DOI":"10.1016\/j.heliyon.2021.e06396","article-title":"Implementation of in silico methods to predict common epitopes for vaccine development against Chikungunya and Mayaro viruses","volume":"7","author":"Hoque","year":"2021","journal-title":"Heliyon"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/s13071-020-04167-2","article-title":"Dynamic proteomic analysis of Aedes aegypti Aag-2 cells infected with Mayaro virus","volume":"13","author":"Vasconcellos","year":"2020","journal-title":"Parasites Vectors"},{"key":"ref_118","first-page":"1","article-title":"Mayaro Virus infection elicits an innate immune response in Anopheles stephensi","volume":"2020","author":"Henderson","year":"2021","journal-title":"bioRxiv"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Bengue, M., Ferraris, P., Barthelemy, J., Diagne, C.T., Hamel, R., Li\u00e9geois, F., Nougair\u00e8de, A., de Lamballerie, X., Simonin, Y., and Pompon, J. (2021). Mayaro Virus Infects Human Brain Cells and Induces a Potent Antiviral Response in Human Astrocytes. Viruses, 13.","DOI":"10.3390\/v13030465"},{"key":"ref_120","unstructured":"De Castro, C.M.O. (2015). An\u00e1lise Metabol\u00f4mica de Altera\u00e7\u00f5es Induzidas Pelo V\u00edrus Mayaro em C\u00e9lulas Vero. [Ph.D. Thesis, Faculty of Medicine of Sao Jose do Rio Preto]."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"883","DOI":"10.2460\/javma.234.7.883","article-title":"Rift Valley fever virus","volume":"234","author":"Bird","year":"2009","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"827","DOI":"10.2174\/156652405774962263","article-title":"Rift Valley fever virus","volume":"5","author":"Flick","year":"2005","journal-title":"Curr. Mol. Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.3201\/eid1712.111035","article-title":"Molecular Epidemiology of Rift Valley Fever Virus","volume":"17","author":"Grobbelaar","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Juma, J., Fonseca, V., Konongoi, S.L., van Heusden, P., Roesel, K., Sang, R., Bett, B., Christoffels, A., de Oliveira, T., and Oyola, S.O. (2022). Genomic surveillance of Rift Valley fever virus: From sequencing to lineage assignment. BMC Genom., 23.","DOI":"10.1186\/s12864-022-08764-6"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1179\/146532806X120363","article-title":"Vertical transmission of fatal Rift Valley fever in a newborn","volume":"26","author":"Arishi","year":"2006","journal-title":"Ann. Trop. Paediatr."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"660","DOI":"10.4049\/jimmunol.89.5.660","article-title":"The development of a formalin-killed Rift Valley fever virus vaccine for use in man","volume":"89","author":"Raymond","year":"1962","journal-title":"J. Immunol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41541-020-0166-9","article-title":"Rift Valley fever virus vaccination induces long-lived, antigen-specific human T cell responses","volume":"5","author":"Harmon","year":"2020","journal-title":"npj Vaccines"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"D62","DOI":"10.1016\/j.vaccine.2009.07.046","article-title":"Rift Valley fever vaccines","volume":"27","author":"Ikegami","year":"2009","journal-title":"Vaccine"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0092-8674(04)00132-1","article-title":"TFIIH Transcription Factor, a Target for the Rift Valley Hemorrhagic Fever Virus","volume":"116","author":"Dubaele","year":"2004","journal-title":"Cell"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Nfon, C.K., Marszal, P., Zhang, S., and Weingartl, H.M. (2012). Innate Immune Response to Rift Valley Fever Virus in Goats. PLOS Negl. Trop. Dis., 6.","DOI":"10.1371\/journal.pntd.0001623"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1128\/JVI.75.3.1371-1377.2001","article-title":"Genetic Evidence for an Interferon-Antagonistic Function of Rift Valley Fever Virus Nonstructural Protein NSs","volume":"75","author":"Bouloy","year":"2001","journal-title":"J. Virol."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Ikegami, T., Narayanan, K., Won, S., Kamitani, W., Peters, C.J., and Makino, S. (2009). Rift Valley Fever Virus NSs Protein Promotes Post-Transcriptional Downregulation of Protein Kinase PKR and Inhibits eIF2\u03b1 Phosphorylation. PLOS Pathog., 5.","DOI":"10.1371\/journal.ppat.1000287"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"13335","DOI":"10.1128\/JVI.01238-07","article-title":"NSm Protein of Rift Valley Fever Virus Suppresses Virus-Induced Apoptosis","volume":"81","author":"Won","year":"2007","journal-title":"J. Virol."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Nuss, J.E., Kehn-Hall, K., Benedict, A., Constantino, J., Ward, M., Peyser, B.D., Retterer, C.J., Tressler, L.E., Wanner, L.M., and McGovern, H.F. (2014). Multi-faceted proteomic characterization of host protein complement of rift valley fever virus virions and identification of specific Heat Shock Proteins, including HSP90, as important viral host factors. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0093483"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"De la Fuente, C., Pinkham, C., Dabbagh, D., Beitzel, B., Garrison, A., Palacios, G., Hodge, K.A., Petricoin, E.F., Schmaljohn, C., and Campbell, C.E. (2018). Phosphoproteomic analysis reveals Smad protein family activation following Rift valley fever virus infection. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0194633"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Popova, T.G., Turell, M.J., Espina, V., Kehn-Hall, K., Kidd, J., Narayanan, A., Liotta, L., Petricoin, E.F., Kashanchi, F., and Bailey, C. (2010). Reverse-phase phosphoproteome analysis of signaling pathways induced by rift valley fever virus in human small airway epithelial cells. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013805"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Le May, N., Mansuroglu, Z., L\u00e9ger, P., Josse, T., Blot, G., Billecocq, A., Flick, R., Jacob, Y., Bonnefoy, E., and Bouloy, M. (2008). A SAP30 Complex Inhibits IFN-\u03b2 Expression in Rift Valley Fever Virus Infected Cells. PLOS Pathog., 4.","DOI":"10.1371\/journal.ppat.0040013"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Havranek, K.E., White, L.A., Lanchy, J.-M., and Lodmell, J.S. (2019). Transcriptome profiling in Rift Valley fever virus infected cells reveals modified transcriptional and alternative splicing programs. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0217497"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.devcel.2010.09.007","article-title":"Integrin-Linked Kinase Controls Microtubule Dynamics Required for Plasma Membrane Targeting of Caveolae","volume":"19","author":"Lange","year":"2010","journal-title":"Dev. Cell"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"10869","DOI":"10.1128\/JVI.01271-09","article-title":"Mutational Analysis Reveals a Noncontractile but Interactive Role of Actin and Profilin in Viral RNA-Dependent RNA Synthesis","volume":"83","author":"Harpen","year":"2009","journal-title":"J. Virol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"14385","DOI":"10.1038\/s41598-017-14800-3","article-title":"Alterations in the host transcriptome in vitro following Rift Valley fever virus infection","volume":"7","author":"Pinkham","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13578-021-00732-z","article-title":"Exosomes originating from infection with the cyto-plasmic single\u2014Stranded RNA virus Rift Valley fever virus (RVFV) protect recipient cells by inducing RIG\u2014I mediated IFN\u2014B response that leads to activation of autophagy","volume":"11","author":"Alem","year":"2021","journal-title":"Cell Biosci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1186\/s13071-020-04253-5","article-title":"In vitro shared transcriptomic re-sponses of Aedes aegypti to arboviral infections: Example of dengue and Rift Valley fever viruses","volume":"13","author":"Licciardi","year":"2020","journal-title":"Parasit. Vectors"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"N\u00fa\u00f1ez, A.I., Esteve-Codina, A., G\u00f3mez-Garrido, J., Brustolin, M., Talavera, S., Berdugo, M., Dabad, M., Alioto, T., Bensaid, A., and Busquets, N. (2020). Alteration in the Culex pipiens transcriptome reveals diverse mechanisms of the mosquito immune system implicated upon Rift Valley fever phlebovirus exposure. PLOS Negl. Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0008870"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"e08936","DOI":"10.1016\/j.heliyon.2022.e08936","article-title":"Metabolomic profile of medicinal plants with anti-RVFV activity","volume":"8","author":"Kgosi","year":"2022","journal-title":"Heliyon"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.3201\/eid1512.090917","article-title":"Oropouche fever outbreak, Manaus, Brazil, 2007\u20132008","volume":"15","author":"Bastos","year":"2009","journal-title":"Emerg. Infect. Dis."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"574","DOI":"10.4269\/ajtmh.1961.10.574","article-title":"Oropouche virus: A new human disease agent from Trinidad, West Indies","volume":"104","author":"Anderson","year":"1961","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.meegid.2018.11.020","article-title":"Oropouche orthobunyavirus: Genetic characterization of full-length genomes and development of molecular methods to discriminate natural reassortments","volume":"68","author":"Nunes","year":"2019","journal-title":"Infect. Genet. Evol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.3201\/eid1110.050464","article-title":"Oropouche virus isolation, southeast Brazil","volume":"11","author":"Nunes","year":"2005","journal-title":"Emerg. Infect. Dis."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1099\/vir.0.000108","article-title":"Genetic analysis of members of the species Oropouche virus and identification of a novel M segment se-quence","volume":"96","author":"Hughes","year":"2015","journal-title":"J. Gen. Virol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.virusres.2008.08.016","article-title":"Oropouche virus entry into HeLa cells involves clathrin and requires endosomal acidification","volume":"138","author":"Santos","year":"2008","journal-title":"Virus Res."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.immuni.2006.08.009","article-title":"Type I inteferon gene induction by the interferon regulatory factor family of tran-scription factors","volume":"25","author":"Honda","year":"2006","journal-title":"Immunity"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.4269\/ajtmh.1981.30.149","article-title":"Oropouche virus. I. A review of clinical, epidemiological, and ecological findings","volume":"30","author":"Pinheiro","year":"1981","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1128\/JVI.00077-15","article-title":"Oropouche virus infection and pathogenesis are restricted by MAVS, IRF-3, IRF-7, and type I interferon signaling pathways in nonmyeloid cells","volume":"89","author":"Pinto","year":"2015","journal-title":"J. Virol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1128\/JVI.02276-15","article-title":"Interferon-regulatory factor 5-dependent signaling restricts Orthobunyavirus dissemination to the central nervous sys-tem","volume":"90","author":"Hyde","year":"2016","journal-title":"J. Virol."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Geddes, V.E.V., De Oliveira, A.S., Tanuri, A., Arruda, E., Ribeiro-Alves, M., and Aguiar, R.S. (2018). MicroRNA and cellular targets profiling reveal miR-217 and miR-576-3p as proviral factors during Oropouche infection. PLOS Negl. Trop. Dis., 12.","DOI":"10.1371\/journal.pntd.0006508"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1590\/S0074-02762012000100007","article-title":"Profile of circulating levels of IL-1Ra, CXCL10\/IP-10, CCL4\/MIP-1\u03b2 and CCL2\/MCP-1 in dengue fever and parvovirosis","volume":"107","author":"Gandini","year":"2012","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"17924","DOI":"10.1038\/s41598-019-54223-w","article-title":"IFN-\u03b1 as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters","volume":"9","author":"Azevedo","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Amorim, M.R., Pontelli, M.C., De Souza, G.F., Muraro, S.P., De Toledo-Teixeira, D.A., Forato, J., Bispo-Dos-Santos, K., Barbosa, N.S., Martini, M.C., and Parise, P.L. (2020). Oropouche Virus Infects, Persists and Induces IFN Response in Human Peripheral Blood Mononuclear Cells as Identified by RNA PrimeFlow\u2122 and qRT-PCR Assays. Viruses, 12.","DOI":"10.3390\/v12070785"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"674576","DOI":"10.3389\/fnins.2021.674576","article-title":"Neural Infection by Oropouche Virus in Adult Human Brain Slices Induces an Inflammatory and Toxic Response","volume":"15","author":"Almeida","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.micro.112408.134243","article-title":"Viruses, microRNAs, and host interactions","volume":"64","author":"Skalsky","year":"2010","journal-title":"Annu. Rev. Microbiol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.ejcb.2015.06.001","article-title":"Orthobunyaviruses and innate immunity induction: AlieNSs vs. PredatoRRs","volume":"94","author":"Schoen","year":"2015","journal-title":"Eur. J. Cell Biol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"e01263-16","DOI":"10.1128\/JVI.01263-16","article-title":"Nonstructural Protein NSs of Schmallenberg Virus Is Targeted to the Nucleolus and Induces Nucleolar Disorganization","volume":"91","author":"Gouzil","year":"2017","journal-title":"J. Virol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1101\/gad.215384.113","article-title":"A genome-wide RNAi screen reveals that mRNA deccaping restricts bunyaviral replication by limiting the pools of Cdp2-accessible targets for cap-snatching","volume":"27","author":"Hopkins","year":"2013","journal-title":"Genes Dev."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"641261","DOI":"10.3389\/fcimb.2021.641261","article-title":"Common Dysregulation of Innate Immunity Pathways in Human Primary Astrocytes Infected With and Zika Viruses","volume":"11","author":"Geddes","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"6718083","DOI":"10.1155\/2018\/6718083","article-title":"Immunoinformatics Approach for Epitope-Based Peptide Vaccine Design and Active Site Prediction against Polyprotein of Emerging Oropouche Virus","volume":"2018","author":"Adhikari","year":"2018","journal-title":"J. Immunol. Res."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/10\/2194\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:46:35Z","timestamp":1760143595000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/10\/2194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,5]]},"references-count":166,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["v14102194"],"URL":"https:\/\/doi.org\/10.3390\/v14102194","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,5]]}}}