{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:21:19Z","timestamp":1793312479433,"version":"4.5.0"},"reference-count":137,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Yibin University","award":["2019QD09"],"award-info":[{"award-number":["2019QD09"]}]},{"name":"Yibin University","award":["2019QD10"],"award-info":[{"award-number":["2019QD10"]}]},{"name":"Yibin University","award":["155-SYLZY201901"],"award-info":[{"award-number":["155-SYLZY201901"]}]},{"name":"Provincial First-Class Undergraduate Major-Biological Engineering","award":["2019QD09"],"award-info":[{"award-number":["2019QD09"]}]},{"name":"Provincial First-Class Undergraduate Major-Biological Engineering","award":["2019QD10"],"award-info":[{"award-number":["2019QD10"]}]},{"name":"Provincial First-Class Undergraduate Major-Biological Engineering","award":["155-SYLZY201901"],"award-info":[{"award-number":["155-SYLZY201901"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Pseudorabies virus (PRV) has received widespread attention for its potential health effects on humans, wildlife, domestic animals, and livestock. In this review, we focus on PRV dynamics in wildlife, given the importance of wild-origin PRV transmission to domestic and farm animals. Wild boars, pigs, and raccoons can serve as reservoirs of PRV, with viral transmission to domestic livestock occurring via several routes, such as wild herd exposure, contaminated meat consumption, and insect vector transmission. Many endangered feline and canine species can be infected with PRV, with acute disease and death within 48 h. The first confirmed human case of PRV infection in mainland China was reported in 2017. Thus, PRV exhibits potentially dangerous cross-host transmission, which is likely associated with inappropriate vaccination, poor awareness, and insufficient biosecurity. Currently, no vaccine provides full protection against PRV in all animals. Here, we summarize the epidemiology and pathogenesis of PRV infection in wild, domestic, and farmed animals, which may facilitate the design of novel therapeutics and strategies for controlling PRV infection and improving wildlife protection in China.<\/jats:p>","DOI":"10.3390\/v14102254","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T05:08:02Z","timestamp":1665983282000},"page":"2254","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Pseudorabies Virus Associations in Wild Animals: Review of Potential Reservoirs for Cross-Host Transmission"],"prefix":"10.3390","volume":"14","author":[{"given":"Aijing","family":"Liu","sequence":"first","affiliation":[{"name":"Yibin Key Laboratory of Zoological Diversity and Ecological Conservation, Faculty of Agriculture, Forestry, and Food Engineering, Yibin University, Yibin 644000, China"},{"name":"State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Xue","sequence":"additional","affiliation":[{"name":"School of Mathematical Science, Harbin Normal University, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Yibin Key Laboratory of Zoological Diversity and Ecological Conservation, Faculty of Agriculture, Forestry, and Food Engineering, Yibin University, Yibin 644000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zou","sequence":"additional","affiliation":[{"name":"Yibin Key Laboratory of Zoological Diversity and Ecological Conservation, Faculty of Agriculture, Forestry, and Food Engineering, Yibin University, Yibin 644000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Pu","sequence":"additional","affiliation":[{"name":"Yibin Key Laboratory of Zoological Diversity and Ecological Conservation, Faculty of Agriculture, Forestry, and Food Engineering, Yibin University, Yibin 644000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4237-1195","authenticated-orcid":false,"given":"Xiaoliang","family":"Hu","sequence":"additional","affiliation":[{"name":"Yibin Key Laboratory of Zoological Diversity and Ecological Conservation, Faculty of Agriculture, Forestry, and Food Engineering, Yibin University, Yibin 644000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhige","family":"Tian","sequence":"additional","affiliation":[{"name":"Yibin Key Laboratory of Zoological Diversity and Ecological Conservation, Faculty of Agriculture, Forestry, and Food Engineering, Yibin University, Yibin 644000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1051\/vetres:200661","article-title":"Cell biological and molecular characteristics of pseudorabies virus infections in cell cultures and in pigs with emphasis on the respiratory tract","volume":"38","author":"Nauwynck","year":"2007","journal-title":"Vet. 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