{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:33:21Z","timestamp":1787729601455,"version":"build-2784847793"},"reference-count":40,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIHR Clinician Scientist Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Rhabdomyolysis is a condition in which muscle breaks down potentially leading to renal dysfunction, and often occurs secondary to a precipitating factor. Viral or bacterial infections are common precipitants for initiating rhabdomyolysis. Recently, healthcare systems across the world have been challenged by a pandemic of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causing \u2018coronavirus disease 2019\u2019 (COVID-19) disease. SARS-CoV-2 infection is recognized to cause respiratory and cardiovascular compromise, thromboembolic events, and acute kidney injury (AKI); however, it is not known whether it can precipitate rhabdomyolysis, with only a limited number of cases of SARS-CoV-2 infection preceding rhabdomyolysis reported to date. Here, we report the case of a 64-year-old woman who developed rhabdomyolysis shortly after SARS-CoV-2 infection and COVID-19. She initially presented with muscular pain, a creatine kinase level of 119,301 IU\/L, and a mild rise in her creatinine level to 92 \u00b5mol\/L, but successfully recovered with intravenous fluid support. We also review the literature to summarise previously reported cases of rhabdomyolysis precipitated by SARS-CoV-2, highlighting the need to consider this diagnosis in patients presenting with SARS-CoV-2 and myalgia.<\/jats:p>","DOI":"10.3390\/v14102255","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T05:08:02Z","timestamp":1665983282000},"page":"2255","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Rhabdomyolysis after COVID-19 Infection: A Case Report and Review of the Literature"],"prefix":"10.3390","volume":"14","author":[{"given":"Monica","family":"Bawor","sequence":"first","affiliation":[{"name":"Department of Medicine, Imperial College Healthcare NHS Trust, London W6 8RF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shwetha","family":"Sairam","sequence":"additional","affiliation":[{"name":"Department of Medicine, Imperial College Healthcare NHS Trust, London W6 8RF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Rozewicz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Imperial College Healthcare NHS Trust, London W6 8RF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Viegas","sequence":"additional","affiliation":[{"name":"Division of Neurology, Imperial College London, London SW7 2BX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander N.","family":"Comninos","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology, and Metabolism, Imperial College London, London SW7 2BX, UK"},{"name":"Department of Endocrinology, Imperial College Healthcare NHS Trust, London W6 8RF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Abbara","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology, and Metabolism, Imperial College London, London SW7 2BX, UK"},{"name":"Department of Endocrinology, Imperial College Healthcare NHS Trust, London W6 8RF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s10238-020-00648-x","article-title":"Organ-specific manifestations of COVID-19 infection","volume":"20","author":"Gavriatopoulou","year":"2020","journal-title":"Clin. Exp. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"100618","DOI":"10.1016\/j.cpcardiol.2020.100618","article-title":"COVID-19 and multiorgan response","volume":"45","author":"Zaim","year":"2020","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_3","first-page":"58","article-title":"Rhabdomyolysis: Pathogenesis, diagnosis, and treatment","volume":"15","author":"Torres","year":"2015","journal-title":"Ochsner J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/cc3221","article-title":"Bench-to-bedside review: Rhabdomyolysis\u2014An overview for clinicians","volume":"9","author":"Varon","year":"2005","journal-title":"Crit. Care"},{"key":"ref_5","first-page":"272","article-title":"Rhabdomyolysis: A review of the literature","volume":"67","author":"Khan","year":"2009","journal-title":"Neth. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e236719","DOI":"10.1136\/bcr-2020-236719","article-title":"Rhabdomyolysis as an initial presentation in a patient diagnosed with COVID-19","volume":"13","year":"2020","journal-title":"BMJ Case Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e237616","DOI":"10.1136\/bcr-2020-237616","article-title":"Rhabdomyolysis and acute kidney injury in severe COVID-19 infection","volume":"13","author":"Taxbro","year":"2020","journal-title":"BMJ Case Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e01212","DOI":"10.1016\/j.idcr.2021.e01212","article-title":"Acute rhabdomyolysis in a young woman with moderate COVID-19","volume":"25","author":"Fujita","year":"2021","journal-title":"IDCases"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.3201\/eid2607.200445","article-title":"Rhabdomyolysis as potential late complication associated with COVID-19","volume":"26","author":"Jin","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"ref_10","first-page":"e7561","article-title":"Rhabdomyolysis as a presentation of 2019 novel coronavirus disease","volume":"12","author":"Suwanwongse","year":"2020","journal-title":"Cureus"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"847","DOI":"10.4269\/ajtmh.20-0583","article-title":"Case report: A COVID-19 patient presenting with mild rhabdomyolysis","volume":"103","author":"Uysal","year":"2020","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_12","first-page":"e10686","article-title":"Rhabdomyolysis in COVID-19: Report of four cases","volume":"12","author":"Singh","year":"2020","journal-title":"Cureus"},{"key":"ref_13","first-page":"2324709620984603","article-title":"Rhabdomyolysis in Patients Hospitalized With COVID-19 Infection: Five Case Series","volume":"8","author":"Khosla","year":"2020","journal-title":"J. Investig. Med. High Impact Case Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1093\/rheumatology\/keaa351","article-title":"Rhabdomyolysis as the main manifestation of coronavirus disease 2019","volume":"59","author":"Bernal","year":"2020","journal-title":"Rheumatology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/j.radcr.2020.07.003","article-title":"Rhabdomyolysis as a manifestation of a severe case of COVID-19: A case report","volume":"15","author":"Husain","year":"2020","journal-title":"Radiol. Case Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e926733-1","DOI":"10.12659\/AJCR.926733","article-title":"Severe rhabdomyolysis in a 35-year-old woman with COVID-19 due to SARS-CoV-2 infection: A case report","volume":"21","author":"Alrubaye","year":"2020","journal-title":"Am. J. Case Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1016\/j.mayocp.2020.09.005","article-title":"Clinical characteristics, diagnosis, and outcomes of 6 patients with COVID-19 infection and rhabdomyolysis","volume":"95","author":"Buckholz","year":"2020","journal-title":"Mayo Clin. Proc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.4269\/ajtmh.20-0692","article-title":"Case report: Rhabdomyolysis in a patient with COVID-19: A proposed diagnostic-therapeutic algorithm","volume":"103","author":"Pineda","year":"2020","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1007\/s11606-020-06039-y","article-title":"COVID-19 and rhabdomyolysis","volume":"35","author":"Chedid","year":"2020","journal-title":"J. Gen. Intern. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e931616-1","DOI":"10.12659\/AJCR.931616","article-title":"Rhabdomyolysis following recovery from severe COVID-19: A case report","volume":"22","author":"Byler","year":"2021","journal-title":"Am. J. Case Rep."},{"key":"ref_21","first-page":"645","article-title":"Case Reports: Rhabdomyolysis associated with COVID-19","volume":"102","author":"Singh","year":"2020","journal-title":"Am. Fam. Physician"},{"key":"ref_22","first-page":"e9556","article-title":"COVID-19 presenting as severe rhabdomyolysis with normal renal function","volume":"12","author":"Shanbhag","year":"2020","journal-title":"Cureus"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/SHK.0000000000001725","article-title":"Rhabdomyolysis is associated with in-hospital mortality in patients with COVID-19","volume":"56","author":"Geng","year":"2021","journal-title":"Shock"},{"key":"ref_24","first-page":"1","article-title":"Muscle manifestations and CK levels in COVID infection: Results of a large cohort of patients inside a Pandemic COVID-19 Area","volume":"40","author":"Verrengia","year":"2021","journal-title":"Acta Myol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jss.2021.03.049","article-title":"Rhabdomyolysis in Severe COVID-19: Male Sex, High Body Mass Index, and Prone Positioning Confer High Risk","volume":"266","author":"Mokhtari","year":"2021","journal-title":"J. Surg. Res."},{"key":"ref_26","first-page":"e12552","article-title":"Rhabdomyolysis in COVID-19 patients: A retrospective observational study","volume":"13","author":"Haroun","year":"2021","journal-title":"Cureus"},{"key":"ref_27","first-page":"e15004","article-title":"Rhabdomyolysis Secondary to COVID-19 Vaccination","volume":"13","author":"Mack","year":"2021","journal-title":"Cureus"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"102170","DOI":"10.1016\/j.dsx.2021.06.007","article-title":"COVID-19 vaccine induced rhabdomyolysis: Case report with literature review","volume":"15","author":"Nassar","year":"2021","journal-title":"Diabetes Metab. Syndr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"845496","DOI":"10.3389\/fimmu.2022.845496","article-title":"Case Report: Severe Rhabdomyolysis and Multiorgan Failure after ChAdOx1 nCoV-19 Vaccination","volume":"13","author":"Cirillo","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.2147\/IDR.S331362","article-title":"Fatal case of rhabdomyolysis post-COVID-19 vaccine","volume":"14","author":"Ajmera","year":"2021","journal-title":"Infect. Drug Resist."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1177\/87551225221093944","article-title":"A Possible Case of COVID-19 Booster Vaccine\u2013Associated Rhabdomyolysis and Acute Kidney Injury","volume":"38","author":"Unger","year":"2022","journal-title":"J. Pharm. Technol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"E252","DOI":"10.1503\/cmaj.211856","article-title":"Possible association between rhabdomyolysis and mRNA SARS-CoV-2 vaccination in a patient with RYR1 gene mutation","volume":"194","author":"Salter","year":"2022","journal-title":"Can. Med. Assoc. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1212\/WNL.98.18_supplement.1265","article-title":"Association between COVID-19 Vaccination and Rhabdomyolysis in Adults: A Vaccine Adverse Event Reporting System (VAERS) Study (S18.006)","volume":"98","author":"Mandava","year":"2022","journal-title":"Neurology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.tmaid.2012.11.004","article-title":"Rhabdomyolysis secondary to influenza A H1N1 vaccine resulting in acute kidney injury","volume":"11","author":"Callado","year":"2013","journal-title":"Travel Med. Infect. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/ndt\/gfi195","article-title":"Influenza vaccine-induced rhabdomyolysis leading to acute renal transplant dysfunction","volume":"21","author":"Raman","year":"2006","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1093\/ndt\/15.5.740","article-title":"Influenza vaccine\u2014A possible trigger of rhabdomyolysis induced acute renal failure due to the combined use of cerivastatin and bezafibrate","volume":"15","author":"Plotkin","year":"2000","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Jacobs, L.G., Gourna Paleoudis, E., Lesky-Di Bari, D., Nyirenda, T., Friedman, T., Gupta, A., Rasouli, L., Zetkulic, M., Balani, B., and Ogedegbe, C. (2020). Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0243882"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Sagarra-Romero, L., and Vi\u00f1as-Barros, A. (2020). COVID-19: Short and long-term effects of hospitalization on muscular weakness in the elderly. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17238715"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"813924","DOI":"10.3389\/fphys.2022.813924","article-title":"The Musculoskeletal Involvement after Mild to Moderate COVID-19 Infection","volume":"13","author":"Sigoli","year":"2022","journal-title":"Front. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.clinph.2021.03.008","article-title":"Is myopathy part of Long-COVID?","volume":"132","author":"Rodriguez","year":"2021","journal-title":"Clin. Neurophysiol."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/10\/2255\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:53:57Z","timestamp":1760144037000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/14\/10\/2255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,14]]},"references-count":40,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["v14102255"],"URL":"https:\/\/doi.org\/10.3390\/v14102255","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,14]]}}}