{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:36:03Z","timestamp":1780479363018,"version":"3.54.1"},"reference-count":40,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"NIH\/NCI","doi-asserted-by":"publisher","award":["R01CA239590"],"award-info":[{"award-number":["R01CA239590"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Kaposi\u2019s sarcoma-associated herpesvirus (KSHV) is associated with vascular endothelial cell tumor, Kaposi\u2019s sarcoma (KS) and lymphoproliferative disorder, multicentric Castleman\u2019s disease (MCD), primary effusion lymphoma (PEL) and KSHV inflammatory cytokine syndrome (KICS). Dysregulation of proinflammatory cytokines is found in most KSHV associated diseases. However, little is known about the role of host microenvironment in the regulation of KSHV establishment in B cells. In the present study, we demonstrated that IFN-\u03b3 has a strong inhibitory effect on KSHV infection but only in a subset of tonsil-derived lymphocyte samples that are intrinsically more susceptible to infection, contain higher proportions of na\u00efve B cells, and display increased levels of IRF1 and STAT1-pY701. The effect of IFN-\u03b3 in responsive samples was associated with increased frequencies of germinal center B cells (GCB) and decreased infection of plasma cells, suggesting that IFN-\u03b3-mediated modulation of viral dynamics in GC can inhibit the establishment of KSHV infection.<\/jats:p>","DOI":"10.3390\/v14102295","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T22:19:53Z","timestamp":1666217993000},"page":"2295","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Host-Level Susceptibility and IRF1 Expression Influence the Ability of IFN-\u03b3 to Inhibit KSHV Infection in B Lymphocytes"],"prefix":"10.3390","volume":"14","author":[{"given":"Nedaa","family":"Alomari","sequence":"first","affiliation":[{"name":"Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA 92618, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8444-8536","authenticated-orcid":false,"given":"Jennifer","family":"Totonchy","sequence":"additional","affiliation":[{"name":"Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA 92618, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1126\/science.7997879","article-title":"Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi\u2019s sarcoma","volume":"266","author":"Chang","year":"1994","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1056\/NEJM199505043321802","article-title":"Kaposi\u2019s sarcoma\u2013associated herpesvirus-like DNA sequences in AIDS-related body-cavity\u2013based lymphomas","volume":"332","author":"Ethel","year":"1995","journal-title":"N. 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