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Scholarship, Talent Research Fund of Heilongjiang Bayi Agricultural University","award":["32072896"],"award-info":[{"award-number":["32072896"]}]},{"name":"The Scholarship, Talent Research Fund of Heilongjiang Bayi Agricultural University","award":["2032030150"],"award-info":[{"award-number":["2032030150"]}]},{"name":"The Scholarship, Talent Research Fund of Heilongjiang Bayi Agricultural University","award":["LBH-Z20083"],"award-info":[{"award-number":["LBH-Z20083"]}]},{"name":"The Scholarship, Talent Research Fund of Heilongjiang Bayi Agricultural University","award":["LH2021C072"],"award-info":[{"award-number":["LH2021C072"]}]},{"name":"The Scholarship, Talent Research Fund of Heilongjiang Bayi Agricultural University","award":["2031011079"],"award-info":[{"award-number":["2031011079"]}]},{"name":"The Scholarship, Talent Research Fund of Heilongjiang Bayi Agricultural University","award":["TDJH202002"],"award-info":[{"award-number":["TDJH202002"]}]},{"name":"Heilongjiang Bayi Agricultural University Support Program for San Heng San Zong","award":["32072896"],"award-info":[{"award-number":["32072896"]}]},{"name":"Heilongjiang Bayi Agricultural University Support Program for San Heng San Zong","award":["2032030150"],"award-info":[{"award-number":["2032030150"]}]},{"name":"Heilongjiang Bayi Agricultural University Support Program for San Heng San Zong","award":["LBH-Z20083"],"award-info":[{"award-number":["LBH-Z20083"]}]},{"name":"Heilongjiang Bayi Agricultural University Support Program for San Heng San Zong","award":["LH2021C072"],"award-info":[{"award-number":["LH2021C072"]}]},{"name":"Heilongjiang Bayi Agricultural University Support Program for San Heng San Zong","award":["2031011079"],"award-info":[{"award-number":["2031011079"]}]},{"name":"Heilongjiang Bayi Agricultural University Support Program for San Heng San Zong","award":["TDJH202002"],"award-info":[{"award-number":["TDJH202002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Bovine viral diarrhea virus (BVDV), a positive-strand RNA virus of the genus Pestivirus in the Flaviviridae family, is the causative agent of viral diarrheal disease in bovine. BVDV has been used as a surrogate model for the hepatitis C virus (HCV) to evaluate the efficacy of antiviral drugs. The plant flavonol quercetin causes multiple health-promoting effects in humans and animals. It can be made into a variety of additives, and it exerts a variety of immunomodulatory effects with the potential to be used as an antiviral agent. However, quercetin\u2019s antiviral effect and mechanism of action on BVDV are still unclear. Therefore, this study was designed to evaluate quercetin\u2019s effect on BVDV virus replication in vitro and in vivo and elucidate its mechanism of action. A CCK-8 kit was used to analyze the toxicity of the quercetin to the MDBK cells. Western blot, qRT-PCR, TCID50, and histological analysis were used to determine the mechanism of quercetin\u2019s anti-BVDV activity. An oxidative stress kit was used to evaluate the effects of quercetin on ROS, antioxidant enzymes, and MDA indexes. The effect of quercetin on IL-2 and IFN-\u03b3 in the serum of mice was determined by using an ELISA kit. The results showed that quercetin inhibits Hsp70, blocks BVDV infection in the early stage of virus infection and inhibits BVDV replication by inhibiting oxidative stress or ERK phosphorylation. In addition, quercetin alleviated the decrease in IFN-\u03b3 and IL-2 in the serum of BVDV-infected mice. Quercetin ameliorated BVDV-induced histopathological changes. In summary, this study demonstrated for the first time the role of Hsp70 in BVDV infection and the potential application of quercetin in treating BVDV infection.<\/jats:p>","DOI":"10.3390\/v14112365","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T04:35:17Z","timestamp":1666845317000},"page":"2365","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Quercetin Inhibits Hsp70 Blocking of Bovine Viral Diarrhea Virus Infection and Replication in the Early Stage of Virus Infection"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6585-7062","authenticated-orcid":false,"given":"Nannan","family":"Chen","sequence":"first","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China"},{"name":"Key Laboratory of Bovine Disease Control in Northeast China, Ministry of Agriculture and Rural Affairs, Daqing 163319, China"},{"name":"Branch of Animal Husbandry and Veterinary of Heilongjiang Academy of Agricultural Sciences, Qiqihar 161006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China"},{"name":"Key Laboratory of Bovine Disease Control in Northeast China, Ministry of Agriculture and Rural Affairs, Daqing 163319, China"},{"name":"Heilongjiang Provincial Engineering Research Center for Prevention and Control of Cattle Diseases, Heilongjiang Bayi Agricultural University, Daqing 163319, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongtong","family":"Bai","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwei","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibo","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baihui","family":"Shao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zecai","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China"},{"name":"Key Laboratory of Bovine Disease Control in Northeast China, Ministry of Agriculture and Rural Affairs, Daqing 163319, China"},{"name":"Heilongjiang Provincial Engineering Research Center for Prevention and Control of Cattle Diseases, Heilongjiang Bayi Agricultural University, Daqing 163319, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China"},{"name":"Key Laboratory of Bovine Disease Control in Northeast China, Ministry of Agriculture and Rural Affairs, Daqing 163319, China"},{"name":"Heilongjiang Provincial Engineering Research Center for Prevention and Control of Cattle Diseases, Heilongjiang Bayi Agricultural University, Daqing 163319, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China"},{"name":"Key Laboratory of Bovine Disease Control in Northeast China, Ministry of Agriculture and Rural Affairs, Daqing 163319, China"},{"name":"Heilongjiang Provincial Engineering Research Center for Prevention and Control of Cattle Diseases, Heilongjiang Bayi Agricultural University, Daqing 163319, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanbo","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China"},{"name":"Key Laboratory of Bovine Disease Control 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