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Fund","award":["ZW7-8515131"],"award-info":[{"award-number":["ZW7-8515131"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) facilitates viral entry into host cells and is the key target for neutralizing antibodies. The SARS-CoV-2 lineage B.1.620 carries fifteen mutations in the S protein and is spread in Africa, the US and Europe, while lineage R.1 harbors four mutations in S and infections were observed in several countries, particularly Japan and the US. However, the impact of the mutations in B.1.620 and R.1 S proteins on antibody-mediated neutralization and host cell entry are largely unknown. Here, we report that these mutations are compatible with robust ACE2 binding and entry into cell lines, and they markedly reduce neutralization by vaccine-induced antibodies. Our results reveal evasion of neutralizing antibodies by B.1.620 and R.1, which might have contributed to the spread of these lineages.<\/jats:p>","DOI":"10.3390\/v14112475","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T02:03:58Z","timestamp":1668045838000},"page":"2475","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Host Cell Entry and Neutralization Sensitivity of SARS-CoV-2 Lineages B.1.620 and R.1"],"prefix":"10.3390","volume":"14","author":[{"given":"Anzhalika","family":"Sidarovich","sequence":"first","affiliation":[{"name":"Infection Biology Unit, German Primate Center, 37077 G\u00f6ttingen, Germany"},{"name":"Faculty of Biology and Psychology, Georg-August-University G\u00f6ttingen, 37073 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4413-8699","authenticated-orcid":false,"given":"Nadine","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"Infection Biology Unit, German Primate Center, 37077 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheila","family":"Rocha","sequence":"additional","affiliation":[{"name":"Infection Biology Unit, German Primate Center, 37077 G\u00f6ttingen, Germany"},{"name":"Faculty of Biology and Psychology, Georg-August-University G\u00f6ttingen, 37073 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luise","family":"Graichen","sequence":"additional","affiliation":[{"name":"Infection Biology Unit, German Primate Center, 37077 G\u00f6ttingen, Germany"},{"name":"Faculty of Biology and Psychology, Georg-August-University G\u00f6ttingen, 37073 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Kempf","sequence":"additional","affiliation":[{"name":"Infection Biology Unit, German Primate Center, 37077 G\u00f6ttingen, Germany"},{"name":"Faculty of Biology and Psychology, Georg-August-University G\u00f6ttingen, 37073 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Nehlmeier","sequence":"additional","affiliation":[{"name":"Infection Biology Unit, German Primate Center, 37077 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1901-6948","authenticated-orcid":false,"given":"Martin","family":"Lier","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of G\u00f6ttingen Medical Center, Georg-August University of G\u00f6ttingen, Robert-Koch-Stra\u00dfe 40, 37075 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Cossmann","sequence":"additional","affiliation":[{"name":"Department for Rheumatology and Immunology, Hannover Medical School, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metodi V.","family":"Stankov","sequence":"additional","affiliation":[{"name":"Department for Rheumatology and Immunology, Hannover Medical School, 30625 Hannover, Germany"},{"name":"German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian R.","family":"Schulz","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology, Department of Internal Medicine 3, Friedrich-Alexander University of Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3111-621X","authenticated-orcid":false,"given":"Georg M. N.","family":"Behrens","sequence":"additional","affiliation":[{"name":"Department for Rheumatology and Immunology, Hannover Medical School, 30625 Hannover, Germany"},{"name":"German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, 30625 Hannover, Germany"},{"name":"Centre for Individualized Infection Medicine (CiiM), Feodor-Lynen-Stra\u00dfe 7, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Martin","family":"J\u00e4ck","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology, Department of Internal Medicine 3, Friedrich-Alexander University of Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6086-9136","authenticated-orcid":false,"given":"Stefan","family":"P\u00f6hlmann","sequence":"additional","affiliation":[{"name":"Infection Biology Unit, German Primate Center, 37077 G\u00f6ttingen, Germany"},{"name":"Faculty of Biology and Psychology, Georg-August-University G\u00f6ttingen, 37073 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Infection Biology Unit, German Primate Center, 37077 G\u00f6ttingen, Germany"},{"name":"Faculty of Biology and Psychology, Georg-August-University G\u00f6ttingen, 37073 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Favresse, J., Gillot, C., Di Chiaro, L., Eucher, C., Elsen, M., Van Eeckhoudt, S., David, C., Morimont, L., Dogn\u00e9, J.-M., and Douxfils, J. 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