{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:45:49Z","timestamp":1792640749122,"version":"4.5.0"},"reference-count":92,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Dengue fever is a mosquito-borne viral disease that has become a serious health issue across the globe. It is caused by a virus of the Flaviviridae family, and it comprises five different serotypes (DENV-1 to DENV-5). As there is no specific medicine or effective vaccine for controlling dengue fever, there is an urgent need to develop potential inhibitors against it. Traditionally, various natural products have been used to manage dengue fever and its co-morbid conditions. A detailed analysis of these plants revealed the presence of various chromene derivatives as the major phytochemicals. Inspired by these observations, authors have critically analyzed the anti-dengue virus potential of various 4H chromene derivatives. Further, in silico, in vitro, and in vivo reports of these scaffolds against the dengue virus are detailed in the present manuscript. These analogues exerted their activity by interfering with various stages of viral entry, assembly, and replications. Moreover, these analogues mainly target envelope protein, NS2B-NS3 protease, and NS5 RNA-dependent RNA polymerase, etc. Overall, chromene-containing analogues exerted a potent activity against the dengue virus and the present review will be helpful for the further exploration of these scaffolds for the development of novel antiviral drug candidates.<\/jats:p>","DOI":"10.3390\/v14122656","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T04:31:16Z","timestamp":1669609876000},"page":"2656","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Inhibitory Potential of Chromene Derivatives on Structural and Non-Structural Proteins of Dengue Virus"],"prefix":"10.3390","volume":"14","author":[{"given":"Babitha Thekkiniyedath","family":"Dharmapalan","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, Kochi 682041, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja","family":"Biswas","sequence":"additional","affiliation":[{"name":"Centre for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Kochi 682041, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathianarayanan","family":"Sankaran","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Karpagam Academy of Higher Education, Karpagam University, Pollachi Main Road, Eachanari Post, Coimbatore 641021, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3888-7079","authenticated-orcid":false,"given":"Baskar","family":"Venkidasamy","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0986-5484","authenticated-orcid":false,"given":"Muthu","family":"Thiruvengadam","sequence":"additional","affiliation":[{"name":"Department of Applied Bioscience, College of Life and Environmental Sciences, Konkuk University, Seoul 05029, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7131-2496","authenticated-orcid":false,"given":"Ginson","family":"George","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, Kochi 682041, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0857-5143","authenticated-orcid":false,"given":"Maksim","family":"Rebezov","sequence":"additional","affiliation":[{"name":"Department of Scientific Research, K.G. Razumovsky Moscow State University of Technologies and Management (The First Cossack University), 73 Zemlyanoy Val, 109004 Moscow, Russia"},{"name":"Department of Scientific Research, Russian State Agrarian University\u2014Moscow Timiryazev Agricultural Academy, 49 Timiryazevskaya Str., 127550 Moscow, Russia"},{"name":"Faculty of Biotechnology and Food Engineering, Ural State Agricultural University, 42 Karl Liebknecht Str., 620075 Yekaterinburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-7823","authenticated-orcid":false,"given":"Gokhan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Department of Biology, Science Faculty, Selcuk University, Konya 42130, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6281-426X","authenticated-orcid":false,"given":"Monica","family":"Gallo","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8857-2091","authenticated-orcid":false,"given":"Domenico","family":"Montesano","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5191-7669","authenticated-orcid":false,"given":"Daniele","family":"Naviglio","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, University of Naples Federico II, Via Cintia 4, 80126 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9376-5771","authenticated-orcid":false,"given":"Mohammad Ali","family":"Shariati","sequence":"additional","affiliation":[{"name":"Department of Scientific Research, K.G. Razumovsky Moscow State University of Technologies and Management (The First Cossack University), 73 Zemlyanoy Val, 109004 Moscow, Russia"},{"name":"Department of Scientific Research, Russian State Agrarian University\u2014Moscow Timiryazev Agricultural Academy, 49 Timiryazevskaya Str., 127550 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022, March 19). Dengue and Severe Dengue 2021. Available online: http:\/\/www.who.int\/mediacentre\/factsheets\/fs117\/en\/."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Silva, N.M., Santos, N.C., and Martins, I.C. (2020). Dengue and zika viruses: Epidemiological history, potential therapies, and promising vaccines. Trop. Med. Infect. Dis., 5.","DOI":"10.3390\/tropicalmed5040150"},{"key":"ref_3","unstructured":"World Health Organization (2022, November 23). 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