{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:07:43Z","timestamp":1793308063731,"version":"4.5.0"},"reference-count":35,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Labex Integrative Biology of Emerging Infectious Diseases","award":["ANR-10-LABEX-62-IBEID"],"award-info":[{"award-number":["ANR-10-LABEX-62-IBEID"]}]},{"name":"Labex Integrative Biology of Emerging Infectious Diseases","award":["734548"],"award-info":[{"award-number":["734548"]}]},{"name":"European Union\u2019s Horizon 2020 Research and Innovation Program","award":["ANR-10-LABEX-62-IBEID"],"award-info":[{"award-number":["ANR-10-LABEX-62-IBEID"]}]},{"name":"European Union\u2019s Horizon 2020 Research and Innovation Program","award":["734548"],"award-info":[{"award-number":["734548"]}]},{"name":"French Ministry of Health","award":["ANR-10-LABEX-62-IBEID"],"award-info":[{"award-number":["ANR-10-LABEX-62-IBEID"]}]},{"name":"French Ministry of Health","award":["734548"],"award-info":[{"award-number":["734548"]}]},{"name":"INSERM","award":["ANR-10-LABEX-62-IBEID"],"award-info":[{"award-number":["ANR-10-LABEX-62-IBEID"]}]},{"name":"INSERM","award":["734548"],"award-info":[{"award-number":["734548"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>We aimed to describe adverse pregnancy outcomes among women who had symptomatic, RT-PCR-confirmed ZIKV infection and early childhood outcomes among their infants. We enrolled pregnant women with symptomatic, RT-PCR-confirmed ZIKV infection in a prospective cohort study, and their infants in a prospective pediatric cohort study. We defined adverse pregnancy and early childhood outcomes based on selected neurologic, ophthalmologic, auditory, musculoskeletal, and anthropometric abnormalities. We used RT-PCR and serologic tests to determine the ZIKV infection status of the child. Between 10 March and 24 November 2016, we enrolled 546 pregnant women with RT-PCR-confirmed ZIKV infection. The overall risk of adverse pregnancy and early childhood outcomes possibly related to in utero ZIKV exposure was 15.7% (95% CI: 12.8\u201319.0), distributed as follows: 3.6% (95% CI: 2.3\u20135.6) severe sequelae or fatality; 2.7% (95% CI: 1.6\u20134.5) major abnormalities; 9.4% (95% CI:7.1\u201312.2) mild abnormalities. The risk of severe sequelae or fatality was higher when ZIKV infection occurred during the first trimester (7.0%), compared to the second (2.7%) or third trimester (1.4%) (p = 0.02). Among the infants for whom ZIKV infection status could be determined, the vertical transmission rate was 3.0% (5\/167) (95% CI: 1.1\u20137.2). Among pregnant women with symptomatic, RT-PCR-confirmed ZIKV infection, severe or major pregnancy or early childhood outcomes were present in 6.3% of fetuses and infants. Severe outcomes occurred more frequently in fetuses and infants whose mothers had been infected in the first trimester.<\/jats:p>","DOI":"10.3390\/v14122755","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T03:36:09Z","timestamp":1670816169000},"page":"2755","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Consequences of In Utero Zika Virus Exposure and Adverse Pregnancy and Early Childhood Outcomes: A Prospective Cohort Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8412-8113","authenticated-orcid":false,"given":"Rebecca","family":"Grant","sequence":"first","affiliation":[{"name":"Emerging Disease Epidemiology Unit, Institut Pasteur, 75015 Paris, France"},{"name":"Sorbonne Universit\u00e9, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Flechelles","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de la Martinique, 97261 Fort-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narcisse","family":"Elenga","sequence":"additional","affiliation":[{"name":"Centre Hospitalier de Cayenne, Cayenne 97306, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9585-4281","authenticated-orcid":false,"given":"Beno\u00eet","family":"Tressi\u00e8res","sequence":"additional","affiliation":[{"name":"Centre d\u2019Investigation Clinique Antilles\u2014Guyane, 97142 Pointe-\u00e0-Pitre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2248-8989","authenticated-orcid":false,"given":"Stanie","family":"Gaete","sequence":"additional","affiliation":[{"name":"Karubiotec\u2122, Centre Hospitalier Universitaire de la Guadeloupe, 97142 Pointe-\u00e0-Pitre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Hebert","sequence":"additional","affiliation":[{"name":"Centre Hospitalier de Basse-Terre, 97109 Basse-Terre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Schaub","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de la Martinique, 97261 Fort-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Djossou","sequence":"additional","affiliation":[{"name":"Centre Hospitalier de Cayenne, Cayenne 97306, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeline","family":"Mallard","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de la Guadeloupe, 97142 Pointe-\u00e0-Pitre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucetta","family":"Delver","sequence":"additional","affiliation":[{"name":"Centre Hospitalier de Basse-Terre, 97109 Basse-Terre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Ryan","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de la Guadeloupe, 97142 Pointe-\u00e0-Pitre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"Funk","sequence":"additional","affiliation":[{"name":"Emerging Disease Epidemiology Unit, Institut Pasteur, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Cabi\u00e9","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de la Martinique, 97261 Fort-de-France, France"},{"name":"Pathogenesis and Control of Chronic and Emerging Infections, Universit\u00e9 de Montpellier, Universit\u00e9 des Antilles, INSERM, EFS, 34394 Montpellier, France"},{"name":"Centre d\u2032Investigation Clinique 1424, INSERM, 97261 Fort-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Fontanet","sequence":"additional","affiliation":[{"name":"Emerging Disease Epidemiology Unit, Institut Pasteur, 75015 Paris, France"},{"name":"Conservatoire National des Arts et M\u00e9tiers, 75003 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Hoen","sequence":"additional","affiliation":[{"name":"Centre d\u2019Investigation Clinique Antilles\u2014Guyane, 97142 Pointe-\u00e0-Pitre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/jamapediatrics.2016.3982","article-title":"Characterizing the Pattern of Anomalies in Congenital Zika Syndrome for 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