{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:56:27Z","timestamp":1784822187208,"version":"3.55.0"},"reference-count":60,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"lan Nacional I + D + i, Ministerio de Econom\u00eda y Competitividad (Agencia Estatal de Investigaci\u00f3n), Spain","doi-asserted-by":"publisher","award":["PID2019-109579RB-I00"],"award-info":[{"award-number":["PID2019-109579RB-I00"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"lan Nacional I + D + i, Ministerio de Econom\u00eda y Competitividad (Agencia Estatal de Investigaci\u00f3n), Spain","doi-asserted-by":"publisher","award":["PID2021-124671OB-I00"],"award-info":[{"award-number":["PID2021-124671OB-I00"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Viruses"],"abstract":"<jats:p>Effector-triggered immunity (ETI) is one of the most studied mechanisms of plant resistance to viruses. During ETI, viral proteins are recognized by specific plant R proteins, which most often trigger a hypersensitive response (HR) involving programmed cell death (PCD) and a restriction of infection in the initially infected sites. However, in some plant\u2013virus interactions, ETI leads to a response in which PCD and virus multiplication are not restricted to the entry sites and spread throughout the plant, leading to systemic necrosis. The host and virus genetic determinants, and the consequences of this response in plant\u2013virus coevolution, are still poorly understood. Here, we identified an allelic version of RCY1\u2014an R protein\u2014as the host genetic determinant of broad-spectrum systemic necrosis induced by cucumber mosaic virus (CMV) infection in the Arabidopsis thaliana Co-1 ecotype. Systemic necrosis reduced virus fitness by shortening the infectious period and limiting virus multiplication; thus, this phenotype could be adaptive for the plant population as a defense against CMV. However, the low frequency (less than 1%) of this phenotype in A. thaliana wild populations argues against this hypothesis. These results expand current knowledge on the resistance mechanisms to virus infections associated with ETI in plants.<\/jats:p>","DOI":"10.3390\/v14122790","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T02:20:57Z","timestamp":1671070857000},"page":"2790","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cucumber Mosaic Virus-Induced Systemic Necrosis in Arabidopsis thaliana: Determinants and Role in Plant Defense"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8876-1194","authenticated-orcid":false,"given":"Israel","family":"Pag\u00e1n","sequence":"first","affiliation":[{"name":"Centro de Biotecnolog\u00eda y Gen\u00f3mica de Plantas UPM-INIA\/CSIC and Departamento de Biotecnolog\u00eda-Biolog\u00eda Vegetal, E.T.S. Ingenier\u00eda Agron\u00f3mica, Alimentaria y de Biosistemas, Universidad Polit\u00e9cnica de Madrid, 28045 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5327-3200","authenticated-orcid":false,"given":"Fernando","family":"Garc\u00eda-Arenal","sequence":"additional","affiliation":[{"name":"Centro de Biotecnolog\u00eda y Gen\u00f3mica de Plantas UPM-INIA\/CSIC and Departamento de Biotecnolog\u00eda-Biolog\u00eda Vegetal, E.T.S. Ingenier\u00eda Agron\u00f3mica, Alimentaria y de Biosistemas, Universidad Polit\u00e9cnica de Madrid, 28045 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e2022239118","DOI":"10.1073\/pnas.2022239118","article-title":"The persistent threat of emerging plant disease pandemics to global food security","volume":"118","author":"Ristaino","year":"2021","journal-title":"Proc. Natl. Acad. Sci. 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