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We employed the lectin staining technique, which is a classic influenza virus receptor research method for studying the distribution of viral receptors in the human placenta. In addition, we examined the susceptibility of the human placenta to H1N1\/09, by detecting viral proteins and RNA at different time points post-infection. We found that the human placenta expressed both avian and human influenza A virus receptors (\u03b1-2, 3-linked sialic acid and \u03b1-2, 6-linked sialic acid). In addition, H1N1\/09 did not only infect the human placenta, but also replicated and was released into the culture media. We concluded that the human placenta is susceptible to the 2009 influenza A virus (H1N1\/09) infection, and that particular attention should be paid to shielding pregnant women from infection during influenza season.<\/jats:p>","DOI":"10.3390\/v14122807","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T02:16:41Z","timestamp":1671157001000},"page":"2807","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Tropism and Infectivity of Pandemic Influenza A H1N1\/09 Virus in the Human Placenta"],"prefix":"10.3390","volume":"14","author":[{"given":"Yan-Na","family":"Xiao","sequence":"first","affiliation":[{"name":"Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou 515041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5421-3023","authenticated-orcid":false,"given":"Fei-Yuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou 515041, China"},{"name":"Department of Cell Biology and Genetics, Shantou University Medical College, Shantou 515041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1749-2406","authenticated-orcid":false,"given":"Qian","family":"Xu","sequence":"additional","affiliation":[{"name":"Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou 515041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Gu","sequence":"additional","affiliation":[{"name":"Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou 515041, China"},{"name":"Jinxin Research Institute for Reproductive Medicine and Genetics, Chengdu 610066, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1093\/aje\/kwy146","article-title":"Natality Decline and Spatial Variation in Excess Death Rates During the 1918\u20131920 Influenza Pandemic in Arizona, United States","volume":"187","author":"Dahal","year":"2018","journal-title":"Am. 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