{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:32:44Z","timestamp":1791199964484,"version":"4.2.0"},"reference-count":35,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Palermo","award":["FFR2021"],"award-info":[{"award-number":["FFR2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>In order to acquire information regarding viral agents and epidemiologic features of severe paediatric Viral Acute Gastroenteritis (VAGE) across multiple seasons in the pre-rotavirus-vaccine era, the epidemiologic characteristics of VAGE were investigated among paediatric patients hospitalized in a major Sicilian paediatric hospital from 2003 to 2013. Overall, 4725 children were observed and 2355 (49.8%) were diagnosed with a viral infection: 1448 (30.6%) were found positive to rotavirus, 645 (13.7%) to norovirus, 216 (4.6%) to adenovirus, and 46 (0.97%) to astrovirus. Viral infections showed different patterns of hospitalization in terms of age at risk (younger for rotavirus and adenovirus infections), seasonality (increased risk in winter for rotavirus and norovirus), trend over time (reduced risk in 2011\u20132013 for norovirus and rotavirus) and major diagnostic categories (digestive diseases more frequent in adenovirus and astrovirus but not in norovirus). This study increases general knowledge of VAGE epidemiology and contributes to suggest some a priori diagnostic criteria that could help clinicians to identify and treat viral agents responsible for gastroenteritis in hospital settings.<\/jats:p>","DOI":"10.3390\/v15010041","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T03:02:15Z","timestamp":1671764535000},"page":"41","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinical and Epidemiologic Features of Viral Gastroenteritis in Hospitalized Children: An 11-Year Surveillance in Palermo (Sicily)"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5482-5268","authenticated-orcid":false,"given":"Emanuele","family":"Amodio","sequence":"first","affiliation":[{"name":"Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza \u201cG. D\u2019Alessandro\u201d, Universit\u00e0 degli Studi di Palermo, Via del Vespro 133, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7748-0880","authenticated-orcid":false,"given":"Simona","family":"De Grazia","sequence":"additional","affiliation":[{"name":"Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza \u201cG. D\u2019Alessandro\u201d, Universit\u00e0 degli Studi di Palermo, Via del Vespro 133, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6977-9268","authenticated-orcid":false,"given":"Dario","family":"Genovese","sequence":"additional","affiliation":[{"name":"Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza \u201cG. D\u2019Alessandro\u201d, Universit\u00e0 degli Studi di Palermo, Via del Vespro 133, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9293-5924","authenticated-orcid":false,"given":"Floriana","family":"Bonura","sequence":"additional","affiliation":[{"name":"Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza \u201cG. D\u2019Alessandro\u201d, Universit\u00e0 degli Studi di Palermo, Via del Vespro 133, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Filizzolo","sequence":"additional","affiliation":[{"name":"Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza \u201cG. D\u2019Alessandro\u201d, Universit\u00e0 degli Studi di Palermo, Via del Vespro 133, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Collura","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Microbiologia e Virologia, Ospedale Civico e Di Cristina, ARNAS, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Di Bernardo","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Microbiologia e Virologia, Ospedale Civico e Di Cristina, ARNAS, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7874-6289","authenticated-orcid":false,"given":"Giovanni M.","family":"Giammanco","sequence":"additional","affiliation":[{"name":"Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza \u201cG. D\u2019Alessandro\u201d, Universit\u00e0 degli Studi di Palermo, Via del Vespro 133, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1093\/cid\/civ1013","article-title":"Global, Regional, and National Estimates of Rotavirus Mortality in Children <5 Years of Age, 2000\u20132013","volume":"62","author":"Tate","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"ref_2","first-page":"1","article-title":"Managing Acute Gastroenteritis among Children: Oral Rehydration, Maintenance, and Nutritional Therapy","volume":"52","author":"King","year":"2003","journal-title":"MMWR Recomm. Rep."},{"key":"ref_3","unstructured":"GBD 2017 Causes of Death Collaborators (2018). 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