{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:29:55Z","timestamp":1788881395360,"version":"build-2803163510"},"reference-count":94,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Program of Guangdong Province","award":["2018A030313252"],"award-info":[{"award-number":["2018A030313252"]}]},{"name":"Science and Technology Program of Guangdong Province","award":["JCYJ20190808122605563"],"award-info":[{"award-number":["JCYJ20190808122605563"]}]},{"name":"Science and Technology Program of Guangdong Province","award":["JCYJ20220530153206014"],"award-info":[{"award-number":["JCYJ20220530153206014"]}]},{"name":"Science and Technology Program of Guangdong Province","award":["GDRC202121"],"award-info":[{"award-number":["GDRC202121"]}]},{"name":"Shenzhen Fundamental Research Program","award":["2018A030313252"],"award-info":[{"award-number":["2018A030313252"]}]},{"name":"Shenzhen Fundamental Research Program","award":["JCYJ20190808122605563"],"award-info":[{"award-number":["JCYJ20190808122605563"]}]},{"name":"Shenzhen Fundamental Research Program","award":["JCYJ20220530153206014"],"award-info":[{"award-number":["JCYJ20220530153206014"]}]},{"name":"Shenzhen Fundamental Research Program","award":["GDRC202121"],"award-info":[{"award-number":["GDRC202121"]}]},{"name":"Natural Science Foundation of Top Talent of SZTU","award":["2018A030313252"],"award-info":[{"award-number":["2018A030313252"]}]},{"name":"Natural Science Foundation of Top Talent of SZTU","award":["JCYJ20190808122605563"],"award-info":[{"award-number":["JCYJ20190808122605563"]}]},{"name":"Natural Science Foundation of Top Talent of SZTU","award":["JCYJ20220530153206014"],"award-info":[{"award-number":["JCYJ20220530153206014"]}]},{"name":"Natural Science Foundation of Top Talent of SZTU","award":["GDRC202121"],"award-info":[{"award-number":["GDRC202121"]}]},{"name":"Fundamental Research Funds for Shenzhen Technology University","award":["2018A030313252"],"award-info":[{"award-number":["2018A030313252"]}]},{"name":"Fundamental Research Funds for Shenzhen Technology University","award":["JCYJ20190808122605563"],"award-info":[{"award-number":["JCYJ20190808122605563"]}]},{"name":"Fundamental Research Funds for Shenzhen Technology University","award":["JCYJ20220530153206014"],"award-info":[{"award-number":["JCYJ20220530153206014"]}]},{"name":"Fundamental Research Funds for Shenzhen Technology University","award":["GDRC202121"],"award-info":[{"award-number":["GDRC202121"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Hand, foot, and mouth disease (HFMD) is a highly contagious disease in children caused by a group of enteroviruses. HFMD currently presents a major threat to infants and young children because of a lack of antiviral drugs in clinical practice. Drug repositioning is an attractive drug discovery strategy aimed at identifying and developing new drugs for diseases. Notably, repositioning of well-characterized therapeutics, including either approved or investigational drugs, is becoming a potential strategy to identify new treatments for virus infections. Various types of drugs, including antibacterial, cardiovascular, and anticancer agents, have been studied in relation to their therapeutic potential to treat HFMD. In this review, we summarize the major outbreaks of HFMD and the progress in drug repositioning to treat this disease. We also discuss the structural features and mode of action of these repositioned drugs and highlight the opportunities and challenges of drug repositioning for HFMD.<\/jats:p>","DOI":"10.3390\/v15010075","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T08:42:22Z","timestamp":1672216942000},"page":"75","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Drug Repositioning for Hand, Foot, and Mouth Disease"],"prefix":"10.3390","volume":"15","author":[{"given":"Ran","family":"Yan","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, China"},{"name":"College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"He","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Zhong","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiapeng","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9275-1239","authenticated-orcid":false,"given":"Kai","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7573-5288","authenticated-orcid":false,"given":"Zhe","family":"Ren","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou 510632, China"},{"name":"National Engineering Research Center of Genetic Medicine, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhendan","family":"He","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinchang","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10096-018-3206-x","article-title":"Hand, foot and mouth disease: Current knowledge on clinical manifestations, epidemiology, aetiology and prevention","volume":"37","author":"Esposito","year":"2018","journal-title":"Eur. 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